The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Effects of insulin on left ventricular function during dynamic exercise in overweight and obese subjects
Abstract
AIMS: We designed this study in order to determine the effect of insulin on cardiac function in overweight and obese subjects during exercise. METHODS AND RESULTS: The cardiac function of 62 normal glucose tolerant subjects, aged 30-40 and divided into normal weight (group 1, n=22, BMI 20-24.9 kg/m(2)), overweight (group 2, n=20, BMI 25-29.9 kg/m(2)), and obesity (group 3, n=20, BMI 30-35 kg/m(2)) was evaluated at rest and during dynamic exercise through angiocardioscintigraphy, when on hyperinsulinaemic euglycaemic clamp (test A) and when on normal saline infusion (test B). Left ventricular function at rest was statistically greater (P<0.05) in both tests in overweight and obese subjects compared with normal weight controls, with no statistical difference (P=0.057) within groups between insulin and normal saline infusion. During exercise, cardiac function improved in all the subjects in both tests. The increase was lower in overweight and obese patients, even if statistically significant only in obese vs. control subjects in both tests (P<0.05). Insulin sensitivity showed a significant correlation (P< or =0.001) with left ventricular ejection fraction (LVEF) at rest and with change in LVEF during clamp. CONCLUSION: Our findings suggest a metabolic pathogenesis for the impaired LV function in obesity.
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Reduced insulin resistance may be linked to decreased ejection fraction in individuals with T2DM and in non-diabetic obese patients.
“Reduced insulin resistance may be linked to decreased ejection fraction in individuals with T2DM [44] and in non-diabetic obese patients [45].”
From New Developments in Pharmacological Treatment of Obesity and Type 2 Diabetes—Beyond and within GLP-1 Receptor Agonists (2024) · cites this paper as [45]
Citations
Cites
Effects of isolated obesity on systolic and diastolic left ventricular function
Pascual, M., Pascual, D. A., Soria, F., Vicente, T., Hernández, A. M., Tébar, F. J., & Valdés, M. (2003) · Heart · doi:10.1136/heart.89.10.1152 · Cited by 336
Influence of Excess Fat on Cardiac Morphology and Function: Study in Uncomplicated Obesity
Iacobellis, G., Ribaudo, M. C., Leto, G., Zappaterreno, A., Vecci, E., Di Mario, U., & Leonetti, F. (2002) · Obesity Research · doi:10.1038/oby.2002.104 · Cited by 257
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Research works printed but not linked: 27
- Fisher BM, Gillen G, Dargie HJ et al. The effects of insulin-induced hypoglycaemia on cardiovascular function in normal man: studies using radionuclide ventriculography. Diabetologia1987;30:841–845. · DOI
- Avasthi PS, Greene ER, Voyles WF. Noninvasive Doppler assessment of human postprandial renal blood flow and cardiac output. Am J Physiol1987;252:F1167–F1174. · DOI
- Baron AD, Brechtel G. Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am J Physiol1993;265:E61–E67. · DOI
- Whitlow PL, Rogers WJ, Smith LR et al. Enhancement of left ventricular function by glucose-insulin-potassium infusion in acute myocardial infarction. Am J Cardiol1982;49:811–820. · DOI
- Parsonage WA, Hetmanski D, Cowley AJ. Beneficial haemodynamic effects of insulin in chronic heart failure. Heart2001;85:508–513. · DOI
- Baron AD, Laakso M, Brechtel et al. Reduced postprandial skeletal muscle blood flow contributes to glucose intolerance in human obesity. J Clin Endocrinol Metab1990;70:525–533. · DOI
- Sasso FC, Carbonara O, Cozzolino D et al. Effects of insulin-glucose infusion on left ventricular function at rest and during dynamic exercise in healthy subjects and non insulin dependent diabetic patients. J Am Coll Cardiol2000;36:219–226. · DOI · Paper page
- Parsonage WA, Hetmanski D, Cowley AJ. Differentiation of the metabolic and vascular effects of insulin in insulin resistance in patients with chronic hearth failure. Am J Cardiol2002;89:696–703. · DOI
- Kemppainen J, Tsuchida H, Stolen K et al. Insulin signalling and resistance in patients with chronic heart failure. J Physiol2003;550:305–315. · DOI
- Kasler EK, Hruban RH, Baughman KL. Cardiomyopathy of obesity: a clinicopathologic evaluation of 43 obese patients with heart failure. Am J Cardiol1992;70:921–924. · DOI · Paper page
- Kenchaiah S, Evans JC, Levy D et al. Obesity and the risk of heart failure. N Engl J Med 2002:347:305–313. · DOI · Paper page
- Trovato GM, Catalano D, Caruso G et al. Relationship between cardiac function and insulin resistance in obese patients. Diab Nutr Metab2001;14:325–328.
- Standard of Medical Care in Diabetes. Diabetes Care2004;27(Suppl. 1):S15–S35. · DOI
- Bruce RA. Exercise testing of patients with coronary heart disease. Ann Clinical Res1971;3:323–332.
- Massardo T, Gal RA, Grenier RP et al. Left ventricular volume calculation using a count-based ratio method applied to multigated radionuclide angiography. J Nucl Med1990;31:450–456.
- DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol1979;237:E214–E22. · DOI · Paper page
- Salvadori A, Fanari P, Giacomotti E et al. Kinetics of catecholamines and potassium, and heart rate during exercise testing in obese subjects: heart rate regulation in obesity during exercise. Eur J Nutr2003;42:181–187. · DOI
- Stoddard MF, Tseuda K, Thomas M et al. The influence of obesity on left ventricular filling and systolic function 1992;124:694–699. · DOI
- De Divitis O, Fazio S, Pettito M et al. Obesity and cardiac function. Circulation1981;64:477–482. · DOI
- Mitrakou A, Mokan M, Bolli G et al. Evidence against the hypothesis that hyperinsulinemia increases sympathetic nervous system activity in man. Metabolism1992;41:198–200. · DOI
- Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adults Treatment Panel III). JAMA2001;285:2486–2497. · DOI · Paper page
- Heiss HW, Wink K, Barmeyer J et al. Myocardial oxygen consumption and substrate uptake in man during physiological and pathological volume load. Basic Res Cardiol1977;72:293. · DOI
- Lopaschuk GD, Collins-Nakai RL, Itoi T. Developmental changes in energy substrate use by the heart. Cardiovasc Res1992;26:1172–1180. · DOI
- Ferrannini E, Santoro D, Bonadonna R et al. Metabolic and hemodynamic effects of insulin on human hearts. Am J Physiol1993;264:E308–E315. · DOI
- Camici P, Marraccini P, Marzilli M et al. Coronary hemodynamics and myocardial metabolism during and after pacing stress in normal humans. Am J Physiol1989;257:E309–E317. · DOI
- Young LH, Zaret BL, Barrett EJ. Physiologic hyperinsulinemia stimulates lactate extraction by heart muscle in the conscious dog. Metab Clin Exp1989;38:1115–1119. · DOI
- MacMahon SW, Wilcken DEL, Mac Donald GJ. The effect of weight reduction on left ventricular mass. A randomised controlled trial in young, overweight hypertensive patients. N Engl J Med1986;314:334–339. · DOI
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Sztanek, F., Tóth, L. I., Pető, A., Hernyák, M., Diószegi, Á., & Harangi, M. (2024) · Biomedicines · doi:10.3390/biomedicines12061320 · Cited by 47
“Reduced insulin resistance may be linked to decreased ejection fraction in individuals with T2DM [44] and in non-diabetic obese patients [45].”
Background
Metadata
- Authors
- Sasso, F. C., Carbonara, O., Nasti, R., Marfella, R., Esposito, K., Rambaldi, P., Mansi, L., Salvatore, T., Torella, R., & Cozzolino, D.
- Affiliations
- University of Campania "Luigi Vanvitelli" (IT)
- Corresponding author
- Sasso, Ferdinando C.
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-04-21
- Volume
- 26
- Issue
- 12
- Pages
- 1205-1212
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2159389855
- Cited by
- 20
- References
- 2
- Citations by year
- 2024: 4 · 2022: 1 · 2021: 2 · 2019: 1 · 2015: 3 · 2014: 2
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- insulin, left ventricular function, obesity, overweight, dynamic exercise, hyperinsulinemic-euglycemic clamp, insulin sensitivity, left ventricular ejection fraction, cardiac function
- MeSH terms
- Adult, Analysis of Variance, Exercise Test, Female, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Male, Obesity, Stroke Volume, Glucose Clamp Technique, Exercise, Body Mass Index, Ventricular Function, Left, Ventricular Dysfunction, Left
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