The DOI matches its Crossref record.
Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina
Abstract
AIMS: Ivabradine, a new I(f) inhibitor which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. Ivabradine has shown anti-ischaemic and anti-anginal activity in a placebo-controlled trial. The objective of this study was to compare the anti-anginal and anti-ischaemic effects of ivabradine and the beta-blocker atenolol. METHODS AND RESULTS: In a double-blinded trial, 939 patients with stable angina were randomized to receive ivabradine 5 mg bid for 4 weeks and then either 7.5 or 10 mg bid for 12 weeks or atenolol 50 mg od for 4 weeks and then 100 mg od for 12 weeks. Patients underwent treadmill exercise tests at randomization (M(0)) and after 4 (M(1)) and 16 (M(4)) weeks of therapy. Increases in total exercise duration (TED) at trough at M(4) were 86.8+/-129.0 and 91.7+/-118.8 s with ivabradine 7.5 and 10 mg, respectively and 78.8+/-133.4 s with atenolol 100 mg. Mean differences (SE) when compared with atenolol 100 mg were 10.3 (9.4) and 15.7 (9.5) s in favour of ivabradine 7.5 and 10 mg (P<0.001 for non-inferiority). TED at M(1) improved by 64.2+/-104.0 s with ivabradine 5 mg and by 60.0+/-114.4 s with atenolol 50 mg (P<0.001 for non-inferiority). Non-inferiority of ivabradine was shown at all doses and for all criteria. The number of angina attacks was decreased by two-thirds with both ivabradine and atenolol. CONCLUSION: Ivabradine is as effective as atenolol in patients with stable angina.
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2013 ESC guidelines on the management of stable coronary artery disease
Task Force Members, Montalescot, G., Sechtem, U., Achenbach, S., Andreotti, F., Arden, C., Budaj, A., Bugiardini, R., Crea, F., Cuisset, T., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht296 · Cited by 4,510
Self-citationGraham (2007) · doi:10.1097/01.hjr.0000277983.23934.c9 · Cited by 1,647
Virani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001168 · Cited by 1,598
Fox, K., Ford, I., Steg, P. G., Tendera, M., & Ferrari, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61170-8 · Cited by 1,099
Self-citationResting Heart Rate in Cardiovascular Disease
Fox, K., Borer, J. S., Camm, A. J., Danchin, N., Ferrari, R., Lopez Sendon, J. L., Steg, P. G., Tardif, J.-C., Tavazzi, L., & Tendera, M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.04.079 · Cited by 1,062
Self-citationFihn, S. D., Gardin, J. M., Abrams, J., Berra, K., Blankenship, J. C., Dallas, A. P., Douglas, P. S., Foody, J. M., Gerber, T. C., Hinderliter, A. L., et al. (2012) · Circulation · doi:10.1161/cir.0b013e318277d6a0 · Cited by 845
Virani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.04.003 · Cited by 596
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Self-citationMartin, R. I. R., Pogoryelova, O., Koref, M. S., Bourke, J. P., Teare, M. D., & Keavney, B. D. (2014) · Heart · doi:10.1136/heartjnl-2014-305482 · Cited by 161
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Baruscotti, M., Barbuti, A., & Bucchi, A. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.06.019 · Cited by 149
Ptaszynski, P., Kaczmarek, K., Ruta, J., Klingenheben, T., & Wranicz, J. K. (2013) · Europace · doi:10.1093/europace/eus204 · Cited by 106
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BENEZET‐MAZUECOS, J., RUBIO, J. M., FARRÉ, J., QUIÑONES, M. Á., SANCHEZ‐BORQUE, P., & MACÍA, E. (2013) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12118 · Cited by 55
(2010) · PubMed · Cited by 34
Barzilai, M., & Giris, J. (2015) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10213 · Cited by 31
Das (2017) · doi:10.1161/circheartfailure.117.004112 · Cited by 28
PTASZYNSKI, P., KACZMAREK, K., RUTA, J., KLINGENHEBEN, T., & WRANICZ, J. K. (2013) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12018 · Cited by 23
Metadata
- Authors
- Tardif, J.-C., Ford, I., Tendera, M., Bourassa, M. G., & Fox, K.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-10-07
- Volume
- 26
- Issue
- 23
- Pages
- 2529-2536
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2144207672
- Cited by
- 582
- References
- 0
- FWCI
- 22.27
- Type
- journal article
- Language
- en
- Open access
- closed
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