The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation
Open accessAbstract
AIMS: To assess whether low response to clopidogrel influences cardiovascular outcome after coronary stent implantation in a consecutively measured cohort of patients with coronary stent implantation. METHODS AND RESULTS: A total of 379 consecutive patients with symptomatic coronary artery disease (CAD), (stable angina n = 206 and acute coronary syndrome, n = 173) treated with percutaneous coronary stenting were enrolled in this trial. Responsiveness to clopidogrel was assessed by ADP (20 micromol/L)-induced aggregometry at least 6 h (mean 34.8+/-25.9 h) after administration of a loading dose of 600 mg clopidogrel. Platelet inhibition < 30% was defined as low response to clopidogrel. At 3-month follow-up, the primary outcome of a combined major cardiovascular event including non-fatal myocardial infarction, non-fatal ischaemic stroke, or cardiovascular death was evaluated. Twenty-two patients (5.8%) were classified as low responders. Compared with patients who adequately responded to clopidogrel, a low responder had a significantly higher risk of major cardiovascular events [22.7 vs. 5.6%; odds ratio, 4.9; 95% confidence interval (CI), 1.66-14.96; P = 0.004]. After adjustment for other factors influencing cardiovascular outcome, low response to clopidogrel and severe left ventricular dysfunction were independently associated with a major cardiovascular event within 3 months (hazard ratio for low response to clopidogrel, 3.71; 95% CI, 1.08-12.69; P = 0.037). CONCLUSION: Low response to clopidogrel in patients with symptomatic CAD treated by stenting significantly enhances the occurrence of cardiovascular events and death. The evaluation of low response to clopidogrel may help to identify patients at increased risk who may benefit from intensified antiplatelet strategy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Steinhubl, S. R., Berger, P. B., Mann III, J. T., Fry, E. T. A., DeLago, A., Wilmer, C., Topol, E. J., & for the CREDO Investigators (2002) · JAMA · doi:10.1001/jama.288.19.2411 · Cited by 3,078
Mehta, S. R., Yusuf, S., & Peters, R. J. G. (2002) · ACC Current Journal Review · doi:10.1016/s1062-1458(02)00559-7 · Cited by 2,578
Gurbel, P. A., Bliden, K. P., Hiatt, B. L., & O’Connor, C. M. (2003) · Circulation · doi:10.1161/01.cir.0000072771.11429.83 · Cited by 1,544
Matetzky, S., Shenkman, B., Guetta, V., Shechter, M., Beinart, R., Goldenberg, I., Novikov, I., Pres, H., Savion, N., Varon, D., et al. (2004) · Circulation · doi:10.1161/01.cir.0000130846.46168.03 · Cited by 1,354
Variability in platelet responsiveness to clopidogrel among 544 individuals
Serebruany, V. L., Steinhubl, S. R., Berger, P. B., Malinin, A. I., Bhatt, D. L., & Topol, E. J. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.09.067 · Cited by 777
Platelet Reactivity in Patients and Recurrent Events Post-Stenting
Gurbel, P. A., Bliden, K. P., Guyer, K., Cho, P. W., Zaman, K. A., Kreutz, R. P., Bassi, A. K., & Tantry, U. S. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.07.041 · Cited by 644
Müller, I., Besta, F., Schulz, C., Massberg, S., Schönig, A., & Gawaz, M. (2003) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613462 · Cited by 585
Self-citationClopidogrel Effect on Platelet REactivity in Patients With Stent Thrombosis
Gurbel, P. A., Bliden, K. P., Samara, W., Yoho, J. A., Hayes, K., Fissha, M. Z., & Tantry, U. S. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.07.056 · Cited by 536
Barragan, P., Bouvier, J., Roquebert, P., Macaluso, G., Commeau, P., Comet, B., Lafont, A., Camoin, L., Walter, U., & Eigenthaler, M. (2003) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.10497 · Cited by 434
MÜLLER, I., SEYFARTH, M., RÜDIGER, S., WOLF, B., POGATSA-MURRAY, G., SCHÖMIG, A., & GAWAZ, M. (2001) · Heart · doi:10.1136/heart.85.1.92 · Cited by 405
Self-citation
Cited by
Roffi, M., Patrono, C., Collet, J.-P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv320 · Cited by 8,261
Breet, N. J., van Werkum, J. W., Bouman, H. J., Kelder, J. C., Ruven, H. J. T., Bal, E. T., Deneer, V. H., Harmsze, A. M., van der Heyden, J. A. S., Rensing, B. J. W. M., et al. (2010) · JAMA · doi:10.1001/jama.2010.181 · Cited by 850
Price, M. J., Endemann, S., Gollapudi, R. R., Valencia, R., Stinis, C. T., Levisay, J. P., Ernst, A., Sawhney, N. S., Schatz, R. A., & Teirstein, P. S. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn046 · Cited by 651
Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement
SIBBING, D., SCHULZ, S., BRAUN, S., MORATH, T., STEGHERR, J., MEHILLI, J., SCHÖMIG, A., VON BECKERATH, N., & KASTRATI, A. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03709.x · Cited by 324
Metadata
- Authors
- Geisler, T., Langer, H., Wydymus, M., Gohring, K., Zurn, C., Bigalke, B., Stellos, K., May, A. E., & Gawaz, M.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-09-04
- Volume
- 27
- Issue
- 20
- Pages
- 2420-2425
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2129001881
- Cited by
- 485
- References
- 20
- FWCI
- 35.43
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation. https://app.cochat.ai/papers/10.1093/eurheartj/ehl275
- The paper
- Geisler, T., Langer, H., Wydymus, M., Gohring, K., Zurn, C., Bigalke, B., Stellos, K., May, A. E., & Gawaz, M. (2006). Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation. European Heart Journal. https://doi.org/10.1093/eurheartj/ehl275
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
