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Cited by 188

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: a meta-analysis

Nasr, I. A., Bouzamondo, A., Hulot, J.-S., Dubourg, O., Le Heuzey, J.-Y., Lechat, P.·2007·European Heart Journal

Abstract

AIMS: Atrial fibrillation (AF) is an important morbidity-mortality risk factor, especially in patients with heart failure (HF). Beta-blockers reduce morbidity and mortality in HF. The study was designed to estimate the preventive efficacy of beta-blocker treatment on AF occurrence in patients with HF. METHODS AND RESULTS: A systematic review of the literature was performed to identify all clinical trials evaluating beta-blockers' efficacy in HF. Eligible studies had to be randomized, placebo-controlled and providing information on the incidence of AF during follow-up among those with sinus rhythm at baseline. A total of seven studies which included 11 952 patients receiving a background treatment with angiotensin-converting enzyme-inhibitors could be found. Overall, beta-blockers significantly reduced incidence of onset of AF from 39 to 28 per 1000 patient-years: relative risk reduction=27% (95% confidence interval 14-38, P<0.001); heterogeneity test: P=0.096. A same trend of efficacy was observed in all trials except the SENIORS study. In this trial which included aged patients (>70 years) with systolic or diastolic HF, a higher prevalence of AF at baseline (35%) was observed compared with the mean baseline prevalence (13%). CONCLUSION: Beta-blockers appear to effectively prevent occurrence of AF in patients with systolic HF.

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Metadata

Authors
Nasr, I. A., Bouzamondo, A., Hulot, J.-S., Dubourg, O., Le Heuzey, J.-Y., & Lechat, P.
Venue
European Heart Journal
Published
2007-02-02
Volume
28
Issue
4
Pages
457-462
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
OpenAlex
W2108907637
Cited by
188
References
6
FWCI
9.94
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: a meta-analysis. https://app.cochat.ai/papers/10.1093/eurheartj/ehl484
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Nasr, I. A., Bouzamondo, A., Hulot, J.-S., Dubourg, O., Le Heuzey, J.-Y., & Lechat, P. (2007). Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: a meta-analysis. European Heart Journal. https://doi.org/10.1093/eurheartj/ehl484

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.