The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial
Open accessAbstract
AIMS: Comparison of intracoronary infusion of bone marrow (BM)-derived unselected mononuclear cells (UNSEL) and selected CD34(+)CXCR4(+) cells (SEL) in patients with acute myocardial infarction (AMI) and reduced <40% left ventricular ejection fraction (LVEF). METHODS AND RESULTS: Two hundred patients were randomized to intracoronary infusion of UNSEL (n = 80) or SEL (n = 80) BM cells or to the control (CTRL) group without BM cell treatment. Primary endpoint: change of LVEF and volumes measured by magnetic resonance imaging before and 6 months after the procedure. After 6 months, LVEF increased by 3% (P = 0.01) in patients treated with UNSEL, 3% in patients receiving SEL (P = 0.04) and remained unchanged in CTRL group (P = 0.73). There were no significant differences in absolute changes of LVEF between the groups. Absolute changes of left ventricular end-systolic volume and left ventricular end-diastolic volume were not significantly different in all groups. Significant increase of LVEF was observed only in patients treated with BM cells who had baseline LVEF < median (37%). Baseline LVEF < median and time from the onset of symptoms to primary percutaneous coronary intervention > or = median were predictors of LVEF improvement in patients receiving BM cells. There were no differences in major cardiovascular event (death, re-infarction, stroke, target vessel revascularization) between groups. CONCLUSION: In patients with AMI and impaired LVEF, treatment with BM cells does not lead to a significant improvement of LVEF or volumes. There was however a trend in favour of cell therapy in patients with most severely impaired LVEF and longer delay between the symptoms and revascularization.
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Intracoronary Bone Marrow–Derived Progenitor Cells in Acute Myocardial Infarction
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Intracoronary Injection of Mononuclear Bone Marrow Cells in Acute Myocardial Infarction
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Cited by
Gyöngyösi, M., Wojakowski, W., Lemarchand, P., Lunde, K., Tendera, M., Bartunek, J., Marban, E., Assmus, B., Henry, T. D., Traverse, J. H., et al. (2015) · Circulation Research · doi:10.1161/circresaha.116.304346 · Cited by 313
Self-citationAdult Stem Cell Therapy and Heart Failure, 2000 to 2016: A Systematic Review
Nguyen, P. K., Rhee, J.-W., & Wu, J. C. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.2225 · Cited by 299
Yoshida, S., Miyagawa, S., Fukushima, S., Kawamura, T., Kashiyama, N., Ohashi, F., Toyofuku, T., Toda, K., & Sawa, Y. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.08.012 · Cited by 178
Metadata
- Authors
- Tendera, M., Wojakowski, W., Rużyłło, W., Chojnowska, L., Kępka, C., Tracz, W., Musiałek, P., Piwowarska, W., Nessler, J., Buszman, P., Grajek, S., Bręborowicz, P., Majka, M., & Ratajczak, M. Z.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02-10
- Volume
- 30
- Issue
- 11
- Pages
- 1313-1321
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2098266872
- Cited by
- 473
- References
- 26
- FWCI
- 27.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Tendera, M., Wojakowski, W., Rużyłło, W., Chojnowska, L., Kępka, C., Tracz, W., Musiałek, P., Piwowarska, W., Nessler, J., Buszman, P., Grajek, S., Bręborowicz, P., Majka, M., & Ratajczak, M. Z. (2009). Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial. European Heart Journal. https://doi.org/10.1093/eurheartj/ehp073
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
