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Cited by 379

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study

Cheng, Jin M., Garcia-Garcia, Hector M., de Boer, Sanneke P.M., Kardys, Isabella, Heo, Jung Ho, Akkerhuis, K. Martijn, Oemrawsingh, Rohit M., van Domburg, Ron T., Ligthart, Jurgen, Witberg, Karen T., Regar, Evelyn, Serruys, Patrick W., van Geuns, Robert-Jan, Boersma, Eric·2014·European Heart Journal
DOI 10.1093/eurheartj/eht484
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Abstract

AIMS: Acute coronary syndromes (ACS) are mostly caused by plaque rupture. This study aims to investigate the prognostic value of in vivo detection of high-risk coronary plaques by intravascular ultrasound (IVUS) in patients undergoing coronary angiography. METHODS AND RESULTS: Between November 2008 and January 2011, IVUS of a non-culprit coronary artery was performed in 581 patients who underwent coronary angiography for ACS (n = 318) or stable angina (n = 263). Primary endpoint was major adverse cardiac events (MACEs) defined as mortality, ACS, or unplanned coronary revascularization. Culprit lesion-related events were not counted. Cumulative Kaplan-Meier incidence of 1-year MACE was 7.8%. The presence of IVUS virtual histology-derived thin-cap fibroatheroma (TCFA) lesions (present 10.8% vs. absent 5.6%; adjusted HR: 1.98, 95% CI: 1.09-3.60; P = 0.026) and lesions with a plaque burden of ≥70% (present 16.2% vs. absent 5.5%; adjusted HR: 2.90, 95% CI: 1.60-5.25; P < 0.001) were independently associated with a higher MACE rate. Thin-cap fibroatheroma lesions were also independently associated with the composite of death or ACS only (present 7.5% vs. absent 3.0%; adjusted HR: 2.51, 95% CI: 1.15-5.49; P = 0.021). Thin-cap fibroatheroma lesions with a plaque burden of ≥70% were associated with a higher MACE rate within (P = 0.011) and after (P < 0.001) 6 months of follow-up, while smaller TCFA lesions were only associated with a higher MACE rate after 6 months (P = 0.033). CONCLUSION: In patients undergoing coronary angiography, the presence of IVUS virtual histology-derived TCFA lesions in a non-culprit coronary artery is strongly and independently predictive for the occurrence of MACE within 1 year, particularly of death and ACS. Thin-cap fibroatheroma lesions with a large plaque burden carry higher risk than small TCFA lesions, especially on the short term.

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Metadata

Authors
Cheng, J. M., Garcia-Garcia, H. M., de Boer, S. P. M., Kardys, I., Heo, J. H., Akkerhuis, K. M., Oemrawsingh, R. M., van Domburg, R. T., Ligthart, J., Witberg, K. T., Regar, E., Serruys, P. W., van Geuns, R.-J., & Boersma, E.
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2013-11-19
Volume
35
Issue
10
Pages
639-647
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/eht484
OpenAlex
W2149520723
Cited by
379
References
23
FWCI
26.94
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study. https://app.cochat.ai/papers/10.1093/eurheartj/eht484
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Cheng, J. M., Garcia-Garcia, H. M., de Boer, S. P. M., Kardys, I., Heo, J. H., Akkerhuis, K. M., Oemrawsingh, R. M., van Domburg, R. T., Ligthart, J., Witberg, K. T., Regar, E., Serruys, P. W., van Geuns, R.-J., & Boersma, E. (2014). In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study. European Heart Journal. https://doi.org/10.1093/eurheartj/eht484

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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