The Atrial Fibrillation Ablation Pilot Study: an European Survey on Methodology and results of catheter ablation for atrial fibrillation conducted by the European Heart Rhythm Association
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AIMS: The Atrial Fibrillation Ablation Pilot Study is a prospective registry designed to describe the clinical epidemiology of patients undergoing an atrial fibrillation (AFib) ablation, and the diagnostic/therapeutic processes applied across Europe. The aims of the 1-year follow-up were to analyse how centres assess in routine clinical practice the success of the procedure and to evaluate the success rate and long-term safety/complications. METHODS AND RESULTS: Seventy-two centres in 10 European countries were asked to enrol 20 consecutive patients undergoing a first AFib ablation procedure. A web-based case report form captured information on pre-procedural, procedural, and 1-year follow-up data. Between October 2010 and May 2011, 1410 patients were included and 1391 underwent an AFib ablation (98.7%). A total of 1300 patients (93.5%) completed a follow-up control 367 ± 42 days after the procedure. Arrhythmia documentation was done by an electrocardiogram in 76%, Holter-monitoring in 52%, transtelephonic monitoring in 8%, and/or implanted systems in 4.5%. Over 50% became asymptomatic. Twenty-one per cent were re-admitted due to post-ablation arrhythmias. Success without antiarrhythmic drugs was achieved in 40.7% of patients (43.7% in paroxysmal AF; 30.2% in persistent AF; 36.7% in long-lasting persistent AF). A second ablation was required in 18% of the cases and 43.4% were under antiarrhythmic treatment. Thirty-three patients (2.5%) suffered an adverse event, 272 (21%) experienced a left atrial tachycardia, and 4 patients died (1 haemorrhagic stroke, 1 ventricular fibrillation in a patient with ischaemic heart disease, 1 cancer, and 1 of unknown cause). CONCLUSION: The AFib Ablation Pilot Study provided crucial information on the epidemiology, management, and outcomes of catheter ablation of AFib in a real-world setting. The methods used to assess the success of the procedure appeared at least suboptimal. Even in this context, the 12-month success rate appears to be somewhat lower to the one reported clinical trials.
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- Authors
- Arbelo, E., Brugada, J., Hindricks, G., Maggioni, A. P., Tavazzi, L., Vardas, P., Laroche, C., Anselme, F., Inama, G., Jais, P., Kalarus, Z., Kautzner, J., Lewalter, T., Mairesse, G. H., Perez-Villacastin, J., Riahi, S., Taborsky, M., Theodorakis, G., Trines, S. A., on the behalf of the Atrial Fibrillation Ablation Pilot Study Investigators, Brugada, J., Arbelo, E., Hindriks, G., Maggioni, A. P., Morgan, J., Tavazzi, L., Vardas, P., Alonso, A., Ferrari, R., Komajda, M., Tavazzi, L., Wood, D., Vardas, P., Brugada, J., Mairesse, G., Taborsky, M., Kautzner, J., Lewalter, T., Riahi, S., Jais, P., Anselme, F., Theodorakis, G., Inama, G., Trines, S., Kalarus, Z., Villacastin, J. P., Maggioni, A. P., Manini, M., Gracia, G., Laroche, C., Missiamenou, V., Taylor, C., Konte, M., Fiorucci, E., Lefrancq, E. F., Glémot, M., McNeill, P.-A., Bois, T., Heidbüchel, H., Nuyens, D., Boland, J., Dinraths, V., Herzet, J.-M., Hoffer, E., Malmendier, D., Massoz, M., Pourbaix, S., Ballant, E., Blommaert, D., Deceuninck, O., Dormal, F., Xhaet, O., De Potter, T., Geelen, P., Derycker, K., Duytschaever, M., Tavernier, R., Vandekerckhove, Y., Vankats, D., Bulava, A., Hanis, J., Sitek, D., Blahova, M., Cihak, R., Hanyasova, L., Jansova, H., Peichl, P., Tanzerova, M., Wichterle, D., Duda, J., Haman, L., Parizek, P., Coling, L., Neuzil, P., Petru, J., Sediva, L., Skoda, J., Chovancik, J., Fiala, M., Neuwirth, R., Karlsdottir, A., Pehrson, S., Gerdes, C., Jensen, H. K., Lukac, P., Nielsen, J. C., Hansen, J., Johannessen, A., Hansen, P. S., Pedersen, A. K., Heath, F. P., Hjortshoj, S., Thogersen, A. M., Da Costa, A., Martel, I., Romeyer-Bouchard, C., Sadki, N., Schmid, A., Haissaguerre, M., Hocini, M., Knecht, S., Sacher, F., Ait Said, M., Cauchemez, B., Ledoux, F., Thomas, O., Cebron, J.-P., Decarsin, N., Gras, D., Hervouet, S., Durand, C., Durand-Dubief, A., Poty, H., Babuty, D., Pierre, B., Albenque, J.-P., Boveda, S., Combes, N., Mas, R., Hermida, J.-S., Kubala, M., Godin, B., Savouré, A., Soublin, Y., Defaye, P., Jacon, P., Brigadeau, F., Corbut, S., Flament-Balzola, F., Kacet, S., Klug, D., Lacroix, D., Copie, X., Gilles, L., Hocine, Z., Paziaud, O., Piot, O., Crocq, C., Kaballu, G., Le Moal, V., Lotton, P., Mabo, P., Pavin, D., Andronache, M., De Chillou, C., Magnin-Poull, I., Deharo, J.-C., Durand, C., Franceschi, F., Peyrouse, E., Prevot, S., Etchegoin, M., Extramiana, F., Leenhardt, A., Messali, A., Heine, T., Schneider, A., Winter, N., Brachmann, J., Ritscher, G., Schertel-Gruenler, B., Simon, H., Sinha, A.-M., Turschner, O., Wystrach, A., Stemberg, M., Kuck, K.-H., Metzner, A., Tilz, R., Wissner, E., Heitmann, K., Willems, S., Andresen, D., Mueller, S., Volkmer, M., Schmidt, B., Kostopoulou, A., Livanis, E., Voudris, V., Efremidis, M., Letsas, K., Tsikrikas, S., Christoforatou, E., Ioannidis, P., Katsivas, A., Kourouklis, S., Andrikopoulos, G., Rassias, I., Tzeis, S., Dakos, G., Paraskevaidis, S., Stavropoulos, G., Theofilogiannakos, E., Vassilikos, V. P., Bongiorni, M. G., Zucchelli, G., Raviele, A., Themistoclakis, S., Pratola, C., Tritto, M., Della Bella, P., Mazzone, P., Moltrasio, M., Tondo, C., Calo, L., De Luca, L., Guarracini, F., Lioy, E., Dozza, L., Frigoli, E., Giannelli, L., Pappone, C., Saviano, M., Schiavina, G., Vicedomini, G. G., De Ponti, R., Doni, L. A., Marazzi, R., Salerno-Uriarte, J. A., Tamborini, C., Anselmino, M., Ferraris, F., Gaita, F., Bertaglia, E., Brandolino, G., Zoppo, F., De Groot, N., Janse, P., Jordaens, L., Pison, L., Roos, C., Van Gelder, I., Manusama, R., Meijer, A., Van der Voort, P., Trines, S., Compier, M. G., Kazmierczak, J., Kornacewicz-Jach, Z., Wielusinski, M., Baran, J., Kulakowski, P., Dzidowski, M., Fuglewicz, A., Nowak, K., Pruszkowska-Skrzep, P., Wozniak, A., Nowak, S., Trusz-Gluza, M., Almendral, J., Atienza, F., Castellanos, E., De Diego, C., Ortiz, M., Moreno Planas, J., Perez Castellano, N., Benezet, J., Farre Muncharaz, J., Rubio Campal, J. M., Hernandez Madrid, A., Matia, R., Arana, E., Pedrote, A., Cozar, R., Peinado, R., Valverde, I., Arbelo, E., Berruezo, A., Calvo, N., Guiu, E., Husseini, S., & Mont Girbau, L.
- Affiliations
- Leipzig University (DE)
- Cliniques du Sud Luxembourg - Vivalia, Arlon, Belgium
- Hospital Clinico San Carlos, Madrid, Spain
- Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
- Hospital Clínic de Barcelona (ES)
- European Society of Cardiology (FR)
- Maria Cecilia Hospital (IT)
- University Hospital of Heraklion (GR)
- Henry Dunant Hospital (GR)
- Hospital Clínico San Carlos (ES)
- Leiden University (NL)
- University Hospital Olomouc (CZ)
- Institute of Clinical and Experimental Medicine (CZ)
- Aalborg University Hospital (DK)
- Hôpital Cardiologique du Haut-Lévêque (FR)
- ORCID
- Hindricks, Gerhard
- Ferrari, Roberto
- Taylor, Charles
- Heidbüchel, H.
- Nuyens, D.
- Herzet, J.-M.
- Pourbaix, S.
- Dormal, F.
- Duytschaever, M.
- Tavernier, R.
- Vandekerckhove, Y.
- Bulava, A.
- Peichl, P.
- Wichterle, D.
- Haman, L.
- Fiala, M.
- Neuwirth, R.
- Pehrson, S.
- Gerdes, C.
- Jensen, H.K.
- Nielsen, J. C.
- Johannessen, A.
- Hansen, P. S.
- Pedersen, A.K.
- Hocini, M.
- Knecht, S.
- Sacher, F.
- Thomas, O.
- Poty, H.
- Babuty, D.
- Combes, N.
- Kubala, M.
- Defaye, P.
- Jacon, P.
- Mabo, P.
- Pavin, D.
- Andronache, M.
- Deharo, J.-C.
- Extramiana, F.
- Leenhardt, A.
- Metzner, A.
- Tilz, R.
- Wissner, E.
- Willems, S.
- Schmidt, B.
- Efremidis, M.
- Ioannidis, P.
- Andrikopoulos, G.
- Tzeis, S.
- Stavropoulos, G.
- Theofilogiannakos, E.
- Vassilikos, V.P.
- Bongiorni, M.G.
- Zucchelli, G.
- Raviele, A.
- Tritto, M.
- Mazzone, P.
- Moltrasio, M.
- Tondo, C.
- Guarracini, F.
- Dozza, L.
- Frigoli, E.
- Giannelli, L.
- Pappone, C.
- Vicedomini, G.G.
- Marazzi, R.
- Anselmino, M.
- Bertaglia, E.
- Brandolino, G.
- Zoppo, F.
- Jordaens, L.
- Pison, L.
- Nowak, K.
- Almendral, J.
- Atienza, F.
- Castellanos, E.
- Ortiz, M.
- Pedrote, A.
- Peinado, R.
- Valverde, I.
- Berruezo, A.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01-31
- Volume
- 35
- Issue
- 22
- Pages
- 1466-1478
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2133698282
- Cited by
- 212
- References
- 44
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 11 · 2023: 13 · 2022: 13 · 2021: 20 · 2020: 15 · 2019: 21 · 2018: 23 · 2017: 16 · 2016: 26 · 2015: 22 · 2014: 15
- FWCI
- 18.06
- Type
- journal article
- Language
- en
- Open access
- green
- vbn.aau.dk
- Licence
- other-oa
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Digital Access to Libraries (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- atrial fibrillation, catheter ablation, ablation success rate, post-ablation arrhythmia, antiarrhythmic drugs, left atrial tachycardia, procedural complications, long-term safety, paroxysmal atrial fibrillation, persistent atrial fibrillation, real-world outcomes, arrhythmia monitoring
- MeSH terms
- Anti-Arrhythmia Agents, Atrial Fibrillation, Electrocardiography, Humans, Patient Readmission, Pilot Projects, Postoperative Care, Prospective Studies, Recurrence, Treatment Outcome, Catheter Ablation, Kaplan-Meier Estimate
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