Risk stratification for sudden cardiac death in hypertrophic cardiomyopathy: systematic review of clinical risk markers
Open accessAbstract
We performed a systematic literature review of recommended 'major' and 'possible' clinical risk markers for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). We searched the Medline, Embase and Cochrane databases for articles published between 1971 and 2007. We included English language reports on HCM patients containing follow-up data on the endpoint (sudden) cardiac death using survival analysis. Analysis was undertaken using the quality of reporting of meta-analyses (QUORUM) statement checklist. The quality was checked using a quality assessment form from the Cochrane Collaboration. Thirty studies met inclusion criteria and passed quality assessment. The use of the six major risk factors (previous cardiac arrest or sustained ventricular tachycardia, non-sustained ventricular tachycardia, extreme left ventricular hypertrophy, unexplained syncope, abnormal blood pressure response, and family history of sudden death) in risk stratification for SCD as recommended by international guidelines was supported by the literature. In addition, left ventricular outflow tract obstruction seems associated with a higher risk of SCD. Our systematic review provides sound evidence for the use of the six major risk factors for SCD in the risk stratification of HCM patients. Left ventricular outflow tract obstruction could be included in the overall risk profile of patients with a marked left ventricular outflow gradient under basal conditions.
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- Authors
- Christiaans, I., van Engelen, K., van Langen, I. M., Birnie, E., Bonsel, G. J., Elliott, P. M., & Wilde, A. A. M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Erasmus MC (NL)
- Corresponding author
- Wilde, Arthur A.M.
- Venue
- EP Europace
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-01-29
- Volume
- 12
- Issue
- 3
- Pages
- 313-321
- ISSN
- 1099-5129 (ISSN-L)
- 1532-2092
- OpenAlex
- W2120813609
- Cited by
- 176
- References
- 69
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 18 · 2018: 20 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 8 · 2013: 16 · 2012: 15
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- EP Europace (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- hypertrophic cardiomyopathy, sudden cardiac death, risk stratification, left ventricular outflow tract obstruction, left ventricular hypertrophy, ventricular tachycardia, syncope, family history of sudden death, blood pressure response, cardiac arrest
- MeSH terms
- Cardiomyopathy, Hypertrophic, Humans, Prognosis, Risk Factors, Death, Sudden, Cardiac, Practice Guidelines as Topic, Risk Assessment
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