The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Pathogens, microbiome and the host: emergence of the ecological Koch's postulates
Open accessAbstract
Even though tremendous progress has been made in the last decades to elucidate the mechanisms of intestinal homeostasis, dysbiosis and disease, we are only at the beginning of understanding the complexity of the gut ecosystem and the underlying interaction networks. We are also only starting to unravel the mechanisms that pathogens have evolved to overcome the barriers imposed by the microbiota and host to exploit the system to their own benefit. Recent work in these domains clearly indicates that the 'traditional Koch's postulates', which state that a given pathogen leads to a distinct disease, are not valid for all 'infectious' diseases, but that a more complete and complex interpretation of Koch's postulates is needed in order to understand and explain them. This review summarises the current understanding of what defines a healthy gut ecosystem and highlights recent progress in uncovering the interplay between the host, its microbiota and invading intestinal pathogens. Based on these recent findings, we propose a new interpretation of Koch's postulates that we term 'ecological Koch's postulates'.
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Cites
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Cited by
Legrand, T. P. R. A., Wynne, J. W., Weyrich, L. S., & Oxley, A. P. A. (2020) · Reviews in Aquaculture · doi:10.1111/raq.12375 · Cited by 265
Iron at the host-microbe interface
Gerner, R. R., Nuccio, S.-P., & Raffatellu, M. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100895 · Cited by 45
Data-driven prediction of colonization outcomes for complex microbial communities
Wu, L., Wang, X.-W., Tao, Z., Wang, T., Zuo, W., Zeng, Y., Liu, Y.-Y., & Dai, L. (2024) · Nature Communications · doi:10.1038/s41467-024-46766-y · Cited by 44
Haydt, N. T., & Neuman-Lee, L. A. (2026) · Frontiers in Amphibian and Reptile Science · doi:10.3389/famrs.2026.1812456
Metadata
- Authors
- Vonaesch, P., Anderson, M., & Sansonetti, P. J.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-01-09
- Volume
- 42
- Issue
- 3
- Pages
- 273-292
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2782662951
- Cited by
- 170
- References
- 57
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- green
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