The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
Abstract
The relationship between the two estimates of genetic variation at the DNA level, namely the number of segregating sites and the average number of nucleotide differences estimated from pairwise comparison, is investigated. It is found that the correlation between these two estimates is large when the sample size is small, and decreases slowly as the sample size increases. Using the relationship obtained, a statistical method for testing the neutral mutation hypothesis is developed. This method needs only the data of DNA polymorphism, namely the genetic variation within population at the DNA level. A simple method of computer simulation, that was used in order to obtain the distribution of a new statistic developed, is also presented. Applying this statistical method to the five regions of DNA sequences in Drosophila melanogaster, it is found that large insertion/deletion (greater than 100 bp) is deleterious. It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Slightly Deleterious Mutant Substitutions in Evolution
OHTA, T. (1973) · Nature · doi:10.1038/246096a0 · Cited by 1,104
Model of effectively neutral mutations in which selective constraint is incorporated
Kimura, M. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.7.3440 · Cited by 254
Cited by
Items 101–113 of 113
PopHuman: the human population genomics browser
Casillas, S., Mulet, R., Villegas-Mirón, P., Hervas, S., Sanz, E., Velasco, D., Bertranpetit, J., Laayouni, H., & Barbadilla, A. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx943 · Cited by 29
A test for ancient selective sweeps and an application to candidate sites in modern humans
Racimo, F., Kuhlwilm, M., & Slatkin, M. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu255 · Cited by 30
A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years
Zhou, H., Hu, S., Matveev, R., Yu, Q., Li, J., Khaitovich, P., Jin, L., Lachmann, M., Stoneking, M., Fu, Q., et al. (2015) · doi:10.1101/018929 · Cited by 28
Albert, F. W., Hodges, E., Jensen, J. D., Besnier, F., Xuan, Z., Rooks, M., Bhattacharjee, A., Brizuela, L., Good, J. M., Green, R. E., et al. (2011) · Heredity · doi:10.1038/hdy.2011.4 · Cited by 28
Ratsimbazafy, H. A., & Kochzius, M. (2018) · Journal of Molluscan Studies · doi:10.1093/mollus/eyy001 · Cited by 25
Liu, X., Li, Z., Yan, Y., Li, Y., Wu, H., Pei, J., Yan, P., Yang, R., Guo, X., & Lan, X. (2021) · Evolutionary Applications · doi:10.1111/eva.13168 · Cited by 23
Samake, J. N., Lavretsky, P., Gunarathna, I., Follis, M., Brown, J. I., Ali, S., Yared, S., & Carter, T. E. (2023) · Molecular Ecology · doi:10.1111/mec.17136 · Cited by 22
Salim, B., Taha, K. M., Hanotte, O., & Mwacharo, J. M. (2014) · Animal Genetics · doi:10.1111/age.12225 · Cited by 20
Babb, P. L., Fernandez-Duque, E., & Schurr, T. G. (2015) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2015.05.006 · Cited by 16
A pathway-centered analysis of pig domestication and breeding in Eurasia
Leno-Colorado, J., Hudson, N. J., Reverter, A., & Pérez-Enciso, M. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.042671 · Cited by 14
Mitochondrial DNA variation of Nigerian domestic helmeted guinea fowl
Adeola, A. C., Ommeh, S. C., Murphy, R. W., Wu, S., Peng, M., & Zhang, Y. (2015) · Animal Genetics · doi:10.1111/age.12324 · Cited by 13
Murunga, P., Kennedy, G. M., Imboma, T., Malaki, P., Kariuki, D., Ndiema, E., Obanda, V., Agwanda, B., Lichoti, J. K., & Ommeh, S. C. (2018) · BioMed Research International · doi:10.1155/2018/7314038 · Cited by 11
Mendonça, P., Carneiro, L. S., Leandro‐Silva, V., Aleixo, A., Araripe, J., & Rêgo, P. S. (2025) · Ecology and Evolution · doi:10.1002/ece3.70331
Metadata
- Authors
- Tajima, F.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-11-01
- Volume
- 123
- Issue
- 3
- Pages
- 585-595
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2140784970
- Cited by
- 13,941
- References
- 2
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
