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The effects of chromosome rearrangements on the expression of heterochromatic genes in chromosome 2L of Drosophila melanogaster.
Open accessAbstract
The light (lt) gene of Drosophila melanogaster is located at the base of the left arm of chromosome 2, within or very near centromeric heterochromatin (2Lh). Chromosome rearrangements that move the lt+ gene from its normal proximal position and place the gene in distal euchromatin result in mosaic or variegated expression of the gene. The cytogenetic and genetic properties of 17 lt-variegated rearrangements are described in this report. We show that five of the heterochromatic genes adjacent to lt are subject to inactivation by these rearrangements and that the euchromatic loci in proximal 2L are not detectably affected. The properties of the rearrangements suggest that proximity to heterochromatin is an important regulatory requirement for at least six 2Lh genes. We discuss how the properties of the position effects on heterochromatic genes relate to other proximity-dependent phenomena such as transvection.
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Citations
Cited by
HETEROCHROMATIN AND GENE EXPRESSION IN DROSOPHILA
Weiler, K. S., & Wakimoto, B. T. (1995) · Annual Review of Genetics · doi:10.1146/annurev.ge.29.120195.003045 · Cited by 533
Self-citationX Chromosome Dosage Compensation: How Mammals Keep the Balance
Payer, B., & Lee, J. T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091711 · Cited by 521
Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila
Dorer, D. (1994) · Cell · doi:10.1016/0092-8674(94)90439-1 · Cited by 506
Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila
Elgin, S. C. R., & Reuter, G. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017780 · Cited by 499
The HP1 protein family: getting a grip on chromatin
Eissenberg, J. C., & Elgin, S. C. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00058-7 · Cited by 468
Metadata
- Authors
- Wakimoto, B. T., & Hearn, M. G.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-05-01
- Volume
- 125
- Issue
- 1
- Pages
- 141-154
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1939654294
- Cited by
- 210
- References
- 0
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The effects of chromosome rearrangements on the expression of heterochromatic genes in chromosome 2L of Drosophila melanogaster. https://app.cochat.ai/papers/10.1093/genetics/125.1.141
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- Wakimoto, B. T., & Hearn, M. G. (1990). The effects of chromosome rearrangements on the expression of heterochromatic genes in chromosome 2L of Drosophila melanogaster. Genetics. https://doi.org/10.1093/genetics/125.1.141
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