The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system.
Abstract
A spontaneous mutation affecting locomotion of the nematode Caenorhabditis elegans has been mapped to a new gene, unc-119. Phenotypic characterization of the mutants suggests the defect does not lie in the musculature and that the animals also have defects in feeding behavior and chemosensation. unc-119 has been physically mapped relative to a previously identified chromosomal break in linkage group III, and DNA clones covering the region can rescue the mutant phenotype in transgenic animals. Three more alleles at the locus, with identical phenotypes, have been induced and characterized, all of which are putative null alleles. The predicted UNC-119 protein has no significant similarity to other known proteins. Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system.
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions
Avery, L., Bargmann, C. I., & Horvitz, H. R. (1993) · Genetics · doi:10.1093/genetics/134.2.455 · Cited by 137
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Metadata
- Authors
- Maduro, M., & Pilgrim, D.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-11-01
- Volume
- 141
- Issue
- 3
- Pages
- 977-988
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2112510720
- Cited by
- 449
- References
- 2
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maduro, M., & Pilgrim, D. (1995). Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics. https://doi.org/10.1093/genetics/141.3.977
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