The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.
Open accessAbstract
Recessive mutations in two genes, daf-2 and age-1, extend the lifespan of Caenorhabditis elegans significantly. The daf-2 gene also regulates formation of an alternative developmental state called the dauer. Here we asked whether these two genes function in the same or different lifespan pathways. We found that the longevity of both age-1 and daf-2 mutants requires the activities of the same two genes, daf-16 and daf-18. In addition, the daf-2(e1370); age-1(hx546) double mutant did not live significantly longer than the daf-2 single mutant. We also found that, like daf-2 mutations, the age-1(hx546) mutation affects certain aspects of dauer formation. These findings suggest that age-1 and daf-2 mutations do act in the same lifespan pathway and extend lifespan by triggering similar if not identical processes.
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Metadata
- Authors
- Dorman, J. B., Albinder, B., Shroyer, T., & Kenyon, C.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-12-01
- Volume
- 141
- Issue
- 4
- Pages
- 1399-1406
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2096541004
- Cited by
- 455
- References
- 12
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. https://app.cochat.ai/papers/10.1093/genetics/141.4.1399
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- Dorman, J. B., Albinder, B., Shroyer, T., & Kenyon, C. (1995). The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics. https://doi.org/10.1093/genetics/141.4.1399
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
