The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Permutation Tests for Multiple Loci Affecting a Quantitative Character
Open accessAbstract
The problem of detecting minor quantitative trait loci (QTL) responsible for genetic variation not explained by major QTL is of importance in the complete dissection of quantitative characters. Two extensions of the permutation-based method for estimating empirical threshold values are presented. These methods, the conditional empirical threshold (CET) and the residual empirical threshold (RET), yield critical values that can be used to construct tests for the presence of minor QTL effects while accounting for effects of known major QTL. The CET provides a completely nonparametric test through conditioning on markers linked to major QTL. It allows for general nonadditive interactions among QTL, but its practical application is restricted to regions of the genome that are unlinked to the major QTL. The RET assumes a structural model for the effect of major QTL, and a threshold is constructed using residuals from this structural model. The search space for minor QTL is unrestricted, and RET-based tests may be more powerful than the CET-based test when the structural model is approximately true.
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Cites
Precision mapping of quantitative trait loci.
Zeng, Z. B. (1994) · Genetics · doi:10.1093/genetics/136.4.1457 · Cited by 3,182
Haley, C. S., & Knott, S. A. (1992) · Heredity · doi:10.1038/hdy.1992.131 · Cited by 1,991
Martínez, O., & Curnow, R. N. (1992) · Theoretical and Applied Genetics · doi:10.1007/bf00222330 · Cited by 355
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The Genetic Architecture of Quantitative Traits
Mackay, T. F. C. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.090633 · Cited by 1,106
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Metadata
- Authors
- Doerge, R. W., & Churchill, G. A.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-01-01
- Volume
- 142
- Issue
- 1
- Pages
- 285-294
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1841573652
- Cited by
- 1,131
- References
- 3
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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