The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Analysis of osm-6, a Gene That Affects Sensory Cilium Structure and Sensory Neuron Function in Caenorhabditis elegans
Abstract
Mutation in the Caenorhabditis elegans gene osm-6 was previously shown to result in defects in the ultrastructure of sensory cilia and defects in chemosensory and mechanosensory behaviors. We have cloned osm-6 by transposon tagging and transformation rescue and have identified molecular lesions associated with five osm-6 mutations. The osm-6 gene encodes a protein that is 40% identical in amino acid sequence to a predicted mammalian protein of unknown function. We fused osm-6 with the gene for green fluorescent protein (GFP); the fusion gene rescued the osm-6 mutant phenotype and showed accumulation of GFP in ciliated sensory neurons exclusively. The OSM-6::GFP protein was localized to cytoplasm, including processes and dendritic endings where sensory cilia are situated. Mutations in other genes known to cause ciliary defects led to changes in the appearance of OSM-6::GFP in dendritic endings or, in the case of daf-19, reduced OSM-6::GFP accumulation. We conclude from an analysis of genetic mosaics that osm-6 acts cell autonomously in affecting cilium structure.
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Cites
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Cited by
Rosenbaum, J. L., & Witman, G. B. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm952 · Cited by 1,423
Pazour, G. J., Dickert, B. L., Vucica, Y., Seeley, E. S., Rosenbaum, J. L., Witman, G. B., & Cole, D. G. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.709 · Cited by 1,147
Cole, D. G., Diener, D. R., Himelblau, A. L., Beech, P. L., Fuster, J. C., & Rosenbaum, J. L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.993 · Cited by 898
Regulation of lifespan by sensory perception in Caenorhabditis elegans
Apfeld, J., & Kenyon, C. (1999) · Nature · doi:10.1038/45544 · Cited by 573
A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans
Barr, M. M., & Sternberg, P. W. (1999) · Nature · doi:10.1038/43913 · Cited by 541
Metadata
- Authors
- Collet, J., Spike, C. A., Lundquist, E. A., Shaw, J. E., & Herman, R. K.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01-01
- Volume
- 148
- Issue
- 1
- Pages
- 187-200
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1949783943
- Cited by
- 241
- References
- 6
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Analysis of osm-6, a Gene That Affects Sensory Cilium Structure and Sensory Neuron Function in Caenorhabditis elegans. https://app.cochat.ai/papers/10.1093/genetics/148.1.187
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- Collet, J., Spike, C. A., Lundquist, E. A., Shaw, J. E., & Herman, R. K. (1998). Analysis of osm-6, a Gene That Affects Sensory Cilium Structure and Sensory Neuron Function in Caenorhabditis elegans. Genetics. https://doi.org/10.1093/genetics/148.1.187
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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