Deficiency Mapping of Quantitative Trait Loci Affecting Longevity in Drosophila melanogaster
Abstract
In a previous study, sex-specific quantitative trait loci (QTL) affecting adult longevity were mapped by linkage to polymorphic roo transposable element markers, in a population of recombinant inbred lines derived from the Oregon and 2b strains of Drosophila melanogaster. Two life span QTL were each located on chromosomes 2 and 3, within sections 33E–46C and 65D–85F on the cytological map, respectively. We used quantitative deficiency complementation mapping to further resolve the locations of life span QTL within these regions. The Oregon and 2b strains were each crossed to 47 deficiencies spanning cytological regions 32F–44E and 64C–76B, and quantitative failure of the QTL alleles to complement the deficiencies was assessed. We initially detected a minimum of five and four QTL in the chromosome 2 and 3 regions, respectively, illustrating that multiple linked factors contribute to each QTL detected by recombination mapping. The QTL locations inferred from deficiency mapping did not generally correspond to those of candidate genes affecting oxidative and thermal stress or glucose metabolism. The chromosome 2 QTL in the 35B–E region was further resolved to a minimum of three tightly linked QTL, containing six genetically defined loci, 24 genes, and predicted genes that are positional candidates corresponding to life span QTL. This region was also associated with quantitative variation in life span in a sample of 10 genotypes collected from nature. Quantitative deficiency complementation is an efficient method for fine-scale QTL mapping in Drosophila and can be further improved by controlling the background genotype of the strains to be tested.
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Some QTL that coarse mapping detects are actually multiple linked variants that cannot be separated into individual SNPs.
“while in an unknown proportion of cases, QTL will turn out to be due to multiple linked variants that coarse mapping fails to resolve into individual SNPs103.”
From Rare and common variants: twenty arguments (2012) · cites this paper as [103]
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- Authors
- Pasyukova, E. G., Vieira, C., & Mackay, T. F. C.
- Affiliations
- Russian Academy of Sciences (RU)
- North Carolina State University (US)
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-11-01
- Volume
- 156
- Issue
- 3
- Pages
- 1129-1146
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1894443853
- Cited by
- 140
- References
- 35
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 1 · 2021: 2 · 2020: 4 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 8
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health (5r03tw000997-03)
- National Institute of General Medical Sciences (GM 45146, R01GM045146)
- Fogarty International Center (TW00997)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- quantitative trait loci, adult longevity, lifespan, Drosophila melanogaster, recombinant inbred lines, chromosome 2, chromosome 3, oxidative stress, thermal stress (biology), glucose metabolism, natural genetic variation
- MeSH terms
- Animals, Chromosome Aberrations, Chromosome Mapping, Drosophila melanogaster, Female, Genetic Complementation Test, Genetic Markers, Inbreeding, Longevity, Male, Recombination, Genetic, Models, Statistical, Gene Deletion, Quantitative Trait, Heritable
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