The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Genetic Analysis of Endocytosis in Caenorhabditis elegans: Coelomocyte Uptake Defective Mutants
Abstract
The coelomocytes of Caenorhabditis elegans are scavenger cells that continuously and nonspecifically endocytose fluid from the pseudocoelom (body cavity). Green fluorescent protein (GFP) secreted into the pseudocoelom from body wall muscle cells is endocytosed and degraded by coelomocytes. We show that toxin-mediated ablation of coelomocytes results in viable animals that fail to endocytose pseudocoelomic GFP, indicating that endocytosis by coelomocytes is not essential for growth or survival of C. elegans under normal laboratory conditions. We examined known viable endocytosis mutants, and performed RNAi for other known endocytosis genes, for coelomocyte uptake defective (Cup) phenotypes. We also screened for new genes involved in endocytosis by isolating viable mutants with Cup defects; this screen identified 14 different genes, many with multiple alleles. A variety of Cup terminal phenotypes were observed, consistent with defects at various steps in the endocytic pathway. Available molecular information indicates that the Cup mutant screen has identified novel components of the endocytosis machinery that are conserved in mammals but not in Saccharomyces cerevisiae, the only other organism for which large-scale genetic screens for endocytosis mutants have been performed.
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,682
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,081
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
Green fluorescent protein as a marker for gene expression
Chalfie, M., Tu, Y., Euskirchen, G., Ward, W. W., & Prasher, D. C. (1994) · Science · doi:10.1126/science.8303295 · Cited by 6,802
Mello, C. C., Kramer, J. M., Stinchcomb, D., & Ambros, V. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04966.x · Cited by 3,112
The Nematode Caenorhabditis elegans
Wood, W. B. (1988) · Cold Spring Harbor Laboratory eBooks · Cited by 2,820
Specific interference by ingested dsRNA
Timmons, L., & Fire, A. (1998) · Nature · doi:10.1038/27579 · Cited by 1,899
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Pathways and mechanisms of endocytic recycling
Grant, B. D., & Donaldson, J. G. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2755 · Cited by 1,424
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
Ben-Zvi, A., Miller, E. A., & Morimoto, R. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902882106 · Cited by 649
RAB-10 Is Required for Endocytic Recycling in the Caenorhabditis elegans Intestine
Chen, C. C.-H., Schweinsberg, P. J., Vashist, S., Mareiniss, D. P., Lambie, E. J., & Grant, B. D. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-08-0787 · Cited by 202
Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME‐4, a coated‐pit protein
Sato, M., Sato, K., Liou, W., Pant, S., Harada, A., & Grant, B. D. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.54 · Cited by 177
IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses
Chen, C., Itakura, E., Nelson, G. M., Sheng, M., Laurent, P., Fenk, L. A., Butcher, R. A., Hegde, R. S., & de Bono, M. (2017) · Nature · doi:10.1038/nature20818 · Cited by 127
Metadata
- Authors
- Fares, H., & Greenwald, I.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-09-01
- Volume
- 159
- Issue
- 1
- Pages
- 133-145
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2168698734
- Cited by
- 285
- References
- 100
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Genetic Analysis of Endocytosis in Caenorhabditis elegans: Coelomocyte Uptake Defective Mutants. https://app.cochat.ai/papers/10.1093/genetics/159.1.133
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- Fares, H., & Greenwald, I. (2001). Genetic Analysis of Endocytosis in Caenorhabditis elegans: Coelomocyte Uptake Defective Mutants. Genetics. https://doi.org/10.1093/genetics/159.1.133
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