The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Analysis of Ras-Induced Overproliferation in Drosophila Hemocytes
Abstract
We use the Drosophila melanogaster larval hematopoietic system as an in vivo model for the genetic and functional genomic analysis of oncogenic cell overproliferation. Ras regulates cell proliferation and differentiation in multicellular eukaryotes. To further elucidate the role of activated Ras in cell overproliferation, we generated a collagen promoter-Gal4 strain to overexpress RasV12 in Drosophila hemocytes. Activated Ras causes a dramatic increase in the number of circulating larval hemocytes (blood cells), which is caused by cellular overproliferation. This phenotype is mediated by the Raf/MAPK pathway. The mutant hemocytes retain the ability to phagocytose bacteria as well as to differentiate into lamellocytes. Microarray analysis of hemocytes overexpressing RasV12 vs. Ras+ identified 279 transcripts that are differentially expressed threefold or more in hemocytes expressing activated Ras. This work demonstrates that it will be feasible to combine genetic and functional genomic approaches in the Drosophila hematopoietic system to systematically identify oncogene-specific downstream targets.
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Cites
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Cited by
Rusten, T. E., Lindmo, K., Juhász, G., Sass, M., Seglen, P. O., Brech, A., & Stenmark, H. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.005 · Cited by 490
Commensal bacteria and essential amino acids control food choice behavior and reproduction
Leitão-Gonçalves, R., Carvalho-Santos, Z., Francisco, A. P., Fioreze, G. T., Anjos, M., Baltazar, C., Elias, A. P., Itskov, P. M., Piper, M. D. W., & Ribeiro, C. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2000862 · Cited by 315
Bachelor, M. A., Lu, Y., & Owens, D. M. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.06.001 · Cited by 46
Wei, Y., Reveal, B., Cai, W., & Lilly, M. A. (2016) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.116.035337 · Cited by 31
Jacomin, A.-C., Bescond, A., Soleilhac, E., Gallet, B., Schoehn, G., Fauvarque, M.-O., & Taillebourg, E. (2015) · PLOS ONE · doi:10.1371/journal.pone.0143078 · Cited by 30
Metadata
- Authors
- Asha, H., Nagy, I., Kovacs, G., Stetson, D., Ando, I., & Dearolf, C. R.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-01-01
- Volume
- 163
- Issue
- 1
- Pages
- 203-215
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1885479805
- Cited by
- 296
- References
- 51
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Asha, H., Nagy, I., Kovacs, G., Stetson, D., Ando, I., & Dearolf, C. R. (2003). Analysis of Ras-Induced Overproliferation in Drosophila Hemocytes. Genetics. https://doi.org/10.1093/genetics/163.1.203
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