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The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila
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USP8 loss of function in D. melanogaster leads to the accumulation of autophagosomes due to a blockade of the autophagic flux.
“In particular, USP8 loss of function in D. melanogaster leads to the accumulation of autophagosomes due to a blockade of the autophagic flux [13,14], whereas in HeLa cells [13] and HEK293T cells [15], USP8 knockdown enhances the autophagic flux.”
From USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons (2023) · cites this paper as [13]
In HeLa and HEK293T cells, USP8 knockdown enhances the autophagic flux.
“In particular, USP8 loss of function in D. melanogaster leads to the accumulation of autophagosomes due to a blockade of the autophagic flux [13,14], whereas in HeLa cells [13] and HEK293T cells [15], USP8 knockdown enhances the autophagic flux.”
From USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons (2023) · cites this paper as [13]
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Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
Bingol, B., Tea, J. S., Phu, L., Reichelt, M., Bakalarski, C. E., Song, Q., Foreman, O., Kirkpatrick, D. S., & Sheng, M. (2014) · Nature · doi:10.1038/nature13418 · Cited by 855
Ubiquitination and selective autophagy
Shaid, S., Brandts, C. H., Serve, H., & Dikic, I. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2012.72 · Cited by 800
USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin
Durcan, T. M., Tang, M. Y., Pérusse, J. R., Dashti, E. A., Aguileta, M. A., McLelland, G., Gros, P., Shaler, T. A., Faubert, D., Coulombe, B., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201489729 · Cited by 375
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Berlin, I., Schwartz, H., & Nash, P. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016287 · Cited by 121
Ubiquitin-specific Peptidase 8 (USP8) Regulates Endosomal Trafficking of the Epithelial Na+ Channel*
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Cited by
Sorted by citations
Mauri, S., Bernardo, G., Martinez, A., Favaro, M., Trevisan, M., Cobraiville, G., Fillet, M., Caicci, F., Whitworth, A. J., & Ziviani, E. (2023) · Cells · doi:10.3390/cells12081143 · Cited by 19
Metadata
- Authors
- Jacomin, A.-C., Bescond, A., Soleilhac, E., Gallet, B., Schoehn, G., Fauvarque, M.-O., & Taillebourg, E.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-11-16
- Volume
- 10
- Issue
- 11
- Pages
- e0143078
- ISSN
- 1932-6203
- PMC
- PMC4646453
- Cited by
- 30
- References
- 9
- Language
- en
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