The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition
Abstract
We herein report on our efforts to improve the mapping resolution of a QTL with major effect on milk yield and composition that was previously mapped to bovine chromosome 20. By using a denser chromosome 20 marker map and by exploiting linkage disequilibrium using two distinct approaches, we provide strong evidence that a chromosome segment including the gene coding for the growth hormone receptor accounts for at least part of the chromosome 20 QTL effect. By sequencing individuals with known QTL genotype, we identify an F to Y substitution in the transmembrane domain of the growth hormone receptor gene that is associated with a strong effect on milk yield and composition in the general population.
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Association mapping: critical considerations shift from genotyping to experimental design
Myles, S., Peiffer, J., Brown, P. J., Ersoz, E. S., Zhang, Z., Costich, D. E., & Buckler, E. S. (2009) · The Plant Cell · doi:10.1105/tpc.109.068437 · Cited by 857
Domestic-animal genomics: deciphering the genetics of complex traits
Andersson, L., & Georges, M. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1294 · Cited by 623
Self-citationThe Fetal Matrix: Evolution, Development and Disease
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Bouwman, A. C., Daetwyler, H. D., Chamberlain, A. J., Ponce, C. H., Sargolzaei, M., Schenkel, F. S., Sahana, G., Govignon-Gion, A., Boitard, S., Dolezal, M., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0056-5 · Cited by 401
Self-citationHarnessing genomic information for livestock improvement
Georges, M., Charlier, C., & Hayes, B. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0082-2 · Cited by 384
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Metadata
- Authors
- Blott, S., Kim, J.-J., Moisio, S., Schmidt-Küntzel, A., Cornet, A., Berzi, P., Cambisano, N., Ford, C., Grisart, B., Johnson, D., Karim, L., Simon, P., Snell, R., Spelman, R., Wong, J., Vilkki, J., Georges, M., Farnir, F., & Coppieters, W.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-01-01
- Volume
- 163
- Issue
- 1
- Pages
- 253-266
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2159349760
- Cited by
- 417
- References
- 33
- FWCI
- 13.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition. https://app.cochat.ai/papers/10.1093/genetics/163.1.253
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- Blott, S., Kim, J.-J., Moisio, S., Schmidt-Küntzel, A., Cornet, A., Berzi, P., Cambisano, N., Ford, C., Grisart, B., Johnson, D., Karim, L., Simon, P., Snell, R., Spelman, R., Wong, J., Vilkki, J., Georges, M., Farnir, F., & Coppieters, W. (2003). Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition. Genetics. https://doi.org/10.1093/genetics/163.1.253
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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