The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Evolution of the Antiaging Action of Dietary Restriction: A Hypothesis
Open accessAbstract
Reducing the intake of dietary energy by laboratory rodents to well below that of animals allowed to eat ad libitum slows the rate of aging. This phenomenon, which is robust and reproducible, is known as the antiaging action of dietary restriction (DR). We hypothesize that this DR response arose because of its evolutionary advantage with respect to survival during periods of unpredictable, short-term food shortage. In our evolutionary scenario, food shortage led to an adaptive redirection of resources away from reproduction toward somatic maintenance via an enhanced heat shock protein response in invertebrates. In vertebrates, an additional involvement of the hypothalamic-adenohypophyseal-adrenal glucocorticoid system was necessitated to protect against excessive systemic defense responses. We suggest several general implications of our hypothesis.
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Cites
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
The Free Hormone Hypothesis: A Physiologically Based Mathematical Model*
MENDEL, C. M. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-3-232 · Cited by 961
Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
Muglia, L., Jacobson, L., Dikkes, P., & Majzoub, J. A. (1995) · Nature · doi:10.1038/373427a0 · Cited by 524
Cited by
Calorie restriction and aging: review of the literature and implications for studies in humans
Heilbronn, L. K., & Ravussin, E. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.361 · Cited by 701
Caloric restriction and aging: an update
Masoro, E. J. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00084-x · Cited by 615
Self-citationAging and Genome Maintenance: Lessons from the Mouse?
Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science · doi:10.1126/science.1079161 · Cited by 553
Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila
Mair, W., Piper, M. D. W., & Partridge, L. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030223 · Cited by 522
Genetics of longevity in model organisms: debates and paradigm shifts
Gems, D., & Partridge, L. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 499
Metadata
- Authors
- Masoro, E. J., & Austad, S. N.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-11-01
- Volume
- 51A
- Issue
- 6
- Pages
- B387-B391
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2111114958
- Cited by
- 189
- References
- 3
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Masoro, E. J., & Austad, S. N. (1996). The Evolution of the Antiaging Action of Dietary Restriction: A Hypothesis. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. https://doi.org/10.1093/gerona/51a.6.b387
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
