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The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly
Abstract
BACKGROUND: IL-6 is a multifunctional cytokine that has been shown to increase with age. METHODS: Plasma IL-6 was measured by ELISA in 1,727 community-dwelling elderly subjects whose blood was drawn during the third in-person survey of the Duke Established Populations for Epidemiologic Studies of the Elderly (EPESE). Demographics, functional status (disability), and disease states were determined. Correlations of these factors with IL-6 were analyzed with Spearman's Rho while differences between groups were assessed by Wilcoxon test. RESULTS: IL-6 levels were higher with age (p = .0001) even in this older population (> 70 years). There was a positive correlation between IL-6 and functional disability for each of the functional status measures (p = .0001), as well as a correlation between self-rated health and IL-6. Significantly higher median levels of IL-6 were found in subjects reporting prevalent cancer, heart attack, and high blood pressure, but not diabetes or arthritis. The association between age and functional status with high IL-6 remained when all other variables were controlled, in multivariable analysis. CONCLUSIONS: This association between increased plasma IL-6 levels and functional status suggests that dysregulation of IL-6 may be related to the functional disability seen with aging, and that IL-6 may be useful as a component of an overall marker of health.
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“High levels of age-associated pro-inflammatory markers are detected in the majority of older individuals, even in the absence of risk factors and clinically active diseases3,5–7.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [5]
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George, L. K., Palmore, E., & Cohen, H. J. (2013) · The Gerontologist · doi:10.1093/geront/gnt049 · Cited by 2
Self-citationDepression in late life: psychiatric-medical comorbidity
Katz, I. R. (1999) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.1999.1.2/ikatz · Cited by 2
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Association of self-rated health with inflammatory markers among nursing home employees
Inoue, Y., Nakata, A., Kurioka, S., Nagata, T., & Mori, K. (2020) · SANGYO EISEIGAKU ZASSHI · doi:10.1539/sangyoeisei.2020-020-b · Cited by 2
An inflammatory clock for healthy aging
Iruela‐Arispe, M. L. (2021) · Nature Aging · doi:10.1038/s43587-021-00085-9 · Cited by 2
Metadata
- Authors
- Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M. K., & Currie, M. S.
- Affiliations
- Duke University (US)
- National Institutes of Health (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-07-01
- Volume
- 52A
- Issue
- 4
- Pages
- M201-M208
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2149814390
- Cited by
- 476
- References
- 35
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 18 · 2023: 14 · 2022: 13 · 2021: 20 · 2020: 23 · 2019: 15 · 2018: 14 · 2017: 13 · 2016: 12 · 2015: 18 · 2014: 15 · 2013: 25 · 2012: 18
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01ag012102-011)
- National Institute on Aging (5P60-AG11268, N01‐AG12102, P60AG011268)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- interleukin-6, plasma cytokines, functional disability, community-dwelling older adults, aging, self-rated health, cancer, myocardial infarction, hypertension, health indicators
- MeSH terms
- Aged, Aging, Community Medicine, Enzyme-Linked Immunosorbent Assay, Female, Persons with Disabilities, Disabled Persons, Health Status, Humans, Male, Self-Assessment, Interleukin-6, Multivariate Analysis
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