Increase of plasma IL-6 concentration with age in healthy subjects

Interleukin-6 and the acute phase response

Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734 · see citing works

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

Arai, K., Lee, F., Miyajima, A., Miyatake, S., Arai, N., & Yokota, T. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.004031 · Cited by 1,318 · see citing works

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 893 · see citing works

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847 · see citing works

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

Frei, K., Malipiero, U., Leist, T. P., Zinkernagel, R. M., Schwab, M. E., & Fontana, A. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190418 · Cited by 690 · see citing works

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

George‐Hyslop, P. S., Haines, J. L., Farrer, L. A., Polinsky, R. J., Broeckhoven, C. V., Goate, A., McLachlan, D. R. C., Orr, H. T., Bruni, A. C., Sorbi, S., et al. (1990) · Nature · doi:10.1038/347194a0 · Cited by 392 · see citing works

Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures

Hama, T., Kushima, Y., Miyamoto, M., Kubota, M., Takei, N., & Hatanaka, H. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90132-8 · Cited by 301 · see citing works

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated ‘acute phase response’ in the brain?

Vandenabeele, P., & Fiers, W. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90032-o · Cited by 264 · see citing works

Blood to brain transport of interleukin links the immune and central nervous systems

Banks, W. A., & Kastin, A. J. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90385-o · Cited by 177 · see citing works

Age-associated increase in interleukin 6 in MRL/lpr mice

Tang, B., Matsuda, T., Akira, S., Nagata, N., Ikehara, S., Hirano, T., & Kishimoto, T. (1991) · International Immunology · doi:10.1093/intimm/3.3.273 · Cited by 159 · see citing works

Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease

van Duijn, C. M., Hofman, A., & Nagelkerken, L. M. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90666-w · Cited by 79 · see citing works

Different responses between thyroxine 5′-monodeiodinase and protein disulfide isomerase activities to dietary fat and thyroid status in rat liver

Tagami, K., Lim, K., Shimomura, Y., & Suzuki, M. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90404-y · Cited by 27 · see citing works

Neuroimmunomodulation takes off

Spector, N. H. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90147-2 · Cited by 19 · see citing works

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388 · see citing works

Evidence for prescribing exercise as therapy in chronic disease

Pedersen, B. K., & Saltin, B. (2006) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2006.00520.x · Cited by 1,384 · see citing works

Relationship of Interleukin-6 and Tumor Necrosis Factor-  With Muscle Mass and Muscle Strength in Elderly Men and Women: The Health ABC Study

Visser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294 · see citing works

Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty

Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282 · see citing works

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267 · see citing works

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works

Proinflammatory Cytokines, Aging, and Age-Related Diseases

Michaud, M., Balardy, L., Moulis, G., Gaudin, C., Peyrot, C., Vellas, B., Cesari, M., & Nourhashemi, F. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.009 · Cited by 1,094 · see citing works

Interleukin (IL)-6, Tumour Necrosis Factor Alpha (TNF-α) and Soluble Interleukin-2 Receptors (SIL-2R) Are Elevated in Patients with Major Depressive Disorder: A Meta-Analysis and Meta-Regression

Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948 · see citing works

Inflammatory mediators in the elderly

Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works

The origins of age-related proinflammatory state

Ferrucci, L., Corsi, A., Lauretani, F., Bandinelli, S., Bartali, B., Taub, D. D., Guralnik, J. M., & Longo, D. L. (2005) · Blood · doi:10.1182/blood-2004-07-2599 · Cited by 908 · see citing works

Inflammatory markers in population studies of aging

Singh, T., & Newman, A. B. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.11.002 · Cited by 866 · see citing works

Estrogen production and action

Nelson, L. R., & Bulun, S. E. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.117432 · Cited by 834 · see citing works

Aromatase—a brief overview

Simpson, E. R., Clyne, C., Rubin, G., Boon, W. C., Robertson, K., Britt, K., Speed, C., & Jones, M. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081601.142703 · Cited by 773 · see citing works

Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway

Maggio, M. G., Guralnik, J. M., Longo, D. L., & Ferrucci, L. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.6.575 · Cited by 687 · see citing works

Aging and proinflammatory cytokines

Bruunsgaard, H., Pedersen, M., & Pedersen, B. K. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200105000-00001 · Cited by 690 · see citing works

The Role of Inflammation in Age-Related Sarcopenia

Dalle, S., Rossmeislova, L., & Koppo, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01045 · Cited by 668 · see citing works

Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.

Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637 · see citing works

Hypertension and aging

Buford, T. W. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.007 · Cited by 589 · see citing works

Steroid sulfatase: molecular biology, regulation, and inhibition

Reed, M. J., Purohit, A., Woo, L. W. L., Newman, S. P., & Potter, B. V. L. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0003 · Cited by 524 · see citing works

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

Ruhland, M. K., Loza, A. J., Capietto, A.-H., Luo, X., Knolhoff, B. L., Flanagan, K. C., Belt, B. A., Alspach, E., Leahy, K., Luo, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms11762 · Cited by 496 · see citing works

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 498 · see citing works

The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly

Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M. K., & Currie, M. S. (1997) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/52a.4.m201 · Cited by 476 · see citing works

Amyloid Precursor Protein, Presenilins, and α-Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer’s Disease

Suh, Y.-H., & Checler, F. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.469 · Cited by 467 · see citing works

Inflammatory markers and the risk of Alzheimer disease: The Framingham Study

Tan, Z. S., Beiser, A. S., Vasan, R. S., Roubenoff, R., Dinarello, C. A., Harris, T. B., Benjamin, E. J., Au, R., Kiel, D. P., Wolf, P. A., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000263217.36439.da · Cited by 440 · see citing works

Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway

Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6912 · Cited by 435 · see citing works

A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies

Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425 · see citing works

(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease

Buford, T. W. (2017) · Microbiome · doi:10.1186/s40168-017-0296-0 · Cited by 409 · see citing works

Ageing, tumour necrosis factor-alpha (TNF- α ) and atherosclerosis

Brüünsgaard, H., Skinhøj, P., Pedersen, B. K., Schroll, M., & Pedersen, B. K. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01281.x · Cited by 402 · see citing works

Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

Dilger, R. N., & Johnson, R. W. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0208108 · Cited by 391 · see citing works

Biomarkers of aging

Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works

Molecular mechanisms of aging-associated inflammation.

Sarkar, D., & Fisher, P. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.04.009 · Cited by 379 · see citing works

Satellite cells in human skeletal muscle plasticity

Snijders, T., Nederveen, J. P., McKay, B. R., Joanisse, S., Verdijk, L. B., van Loon, L. J. C., & Parise, G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00283 · Cited by 359 · see citing works

Serum Dehydroepiandrosterone (DHEA) and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6 Secretion from Mononuclear Cells in Man in Vitro: Possible Link between Endocrinosenescence and Immunosenescence

Straub, R. H., Konecná, L., Hrach, S., Rothe, G., Kreutz, M. P., Schölmerich, J., Falk, W., & Lang, B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4876 · Cited by 352 · see citing works

Exercise, inflammation and aging.

(2012) · Europe PMC (PubMed Central) · Cited by 345 · see citing works

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

Njie, E. G., Boelen, E., Stassen, F. R., Steinbusch, H. W. M., Borchelt, D. R., & Streit, W. J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.008 · Cited by 335 · see citing works

Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis

Haack, M., Hinze‐Selch, D., Fenzel, T., Kraus, T., Kühn, M., Schuld, A., & Pollmächer, T. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00021-7 · Cited by 329 · see citing works

Increased interleukin-6 expression by microglia from brain of aged mice

Ye, S.-M., & Johnson, R. W. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00217-3 · Cited by 326 · see citing works

Association of circulating TNF-α and IL-6 with ageing and parkinsonism

Dobbs, R. J., Charlett, A., Purkiss, A. G., Dobbs, S. M., Weller, C., & Peterson, D. W. (1999) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1999.tb00721.x · Cited by 324 · see citing works

Alterations in resting-state functional connectivity link mindfulness meditation with reduced interleukin-6: a randomized controlled trial

Creswell, J. D., Taren, A. A., Lindsay, E. K., Greco, C. M., Gianaros, P. J., Fairgrieve, A., Marsland, A. L., Brown, K. W., Way, B. M., Rosen, R. K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.01.008 · Cited by 299 · see citing works

Changes in primary lymphoid organs with aging

Chinn, I. K., Blackburn, C. C., Manley, N. R., & Sempowski, G. D. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.005 · Cited by 282 · see citing works

Inflammation and Endometrial Cancer: A Hypothesis

Modugno, F., Ness, R. B., Chen, C., & Weiss, N. S. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0493 · Cited by 250 · see citing works

The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer

Purohit, A., Newman, S. P., & Reed, M. (2002) · Breast Cancer Research · doi:10.1186/bcr425 · Cited by 256 · see citing works

Inflamm-Aging, Cytokines and Aging: State of the Art, New Hypotheses on the Role of Mitochondria and New Perspectives from Systems Biology

Salvioli, S., Capri, M., Valensin, S., Tieri, P., Monti, D., Ottaviani, E., & Franceschi, C. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777947470 · Cited by 240 · see citing works

Prelamin A Accelerates Vascular Calcification Via Activation of the DNA Damage Response and Senescence-Associated Secretory Phenotype in Vascular Smooth Muscle Cells

Liu, Y., Drozdov, I. A., Shroff, R. C., Beltran, L. E., & Shanahan, C. M. (2013) · Circulation Research · doi:10.1161/circresaha.111.300543 · Cited by 238 · see citing works

Plasma and Cerebrospinal Fluid Interleukin-6 Concentrations in Posttraumatic Stress Disorder

Baker, D. G., Ekhator, N. N., Kasckow, J. W., Hill, K. K., Zoumakis, E., Dashevsky, B. A., Chrousos, G. P., & Geracioti Jr., T. D. (2001) · Neuroimmunomodulation · doi:10.1159/000049028 · Cited by 238 · see citing works

Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations

Müller, M. K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2104 · Cited by 237 · see citing works

The inflammation hypothesis in geriatric depression

Alexopoulos, G. S., & Morimoto, S. S. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2672 · Cited by 225 · see citing works

Serum interleukin-6 concentration in schizophrenia: Elevation associated with duration of illness

Ganguli, R., Yang, Z., Shurin, G. V., Chengappa, K. N. R., Brar, J. S., Gubbi, A. V., & Rabin, B. S. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90042-6 · Cited by 222 · see citing works

Mechanisms of vascular calcification in CKD—evidence for premature ageing?

Shanahan, C. M. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.176 · Cited by 208 · see citing works

Linking Chronic Inflammation with Cardiovascular Disease: From Normal Aging to the Metabolic Syndrome.

López‐Candales, A., Burgos, P. M. H., Hernández-Suárez, D. F., & Harris, D. A. (2017) · PubMed · Cited by 203 · see citing works

Aromatase activity and interleukin-6 production by normal and malignant breast tissues

Purohit, A., Ghilchik, M. W., Duncan, L., Wang, D. Y., Singh, A., Walker, M. M., & Reed, M. J. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.10.7559896 · Cited by 201 · see citing works

Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology

Zhang, X. Y., Zhou, D. F., Zhang, P. Y., Wu, G. Y., Cao, L. Y., & Shen, Y. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00296-1 · Cited by 199 · see citing works

The Role of Inflammation in the Pathogenesis of Delirium and Dementia in Older Adults: A Review

Simone, M. J., & Tan, Z. S. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00173.x · Cited by 197 · see citing works

Influence of Physical Activity on Serum IL-6 and IL-10 Levels in Healthy Older Men

Jankord, R., & Jemioło, B. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000128186.09416.18 · Cited by 196 · see citing works

Effects of Music Therapy on Autonomic Nervous System Activity, Incidence of Heart Failure Events, and Plasma Cytokine and Catecholamine Levels in Elderly Patients With Cerebrovascular Disease and Dementia

Okada, K., Kurita, A., Takase, B., Otsuka, T., Kodani, E., Kusama, Y., Atarashi, H., & Mizuno, K. (2009) · International Heart Journal · doi:10.1536/ihj.50.95 · Cited by 185 · see citing works

Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies

Nunes, E. A., Stokes, T., McKendry, J., Currier, B. S., & Phillips, S. M. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00425.2021 · Cited by 183 · see citing works

Plasma Cytokine Levels in a Population-Based Study: Relation to Age and Ethnicity

Stowe, R. P., Peek, M. K., Cutchin, M. P., & Goodwin, J. S. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp198 · Cited by 182 · see citing works

Intramuscular fat and inflammation differ in older adults: The impact of frailty and inactivity

Addison, O. R., Drummond, M. J., LaStayo, P. C., Dibble, L. E., Wende, A. R., McClain, D. A., & Marcus, R. L. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0019-1 · Cited by 181 · see citing works

Understanding the Physiological Links Between Physical Frailty and Cognitive Decline

Ma, L., & Chan, P. (2020) · Aging and Disease · doi:10.14336/ad.2019.0521 · Cited by 175 · see citing works

Interleukin-6 in the aging brain

Godbout, J. P., & Johnson, R. W. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.10.031 · Cited by 173 · see citing works

Interleukin-6 Production Does Not Increase With Age

Beharka, A. A., Meydani, M., Wu, D., Leka, L. S., Meydani, A., & Meydani, S. N. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.2.b81 · Cited by 169 · see citing works

Quantitative and Qualitative Alterations of Acute-phase Proteins in Healthy Elderly Persons

Ballou, S. P., LOZANSKI, G. B., Hodder, S., Rzewnicki, D., MION, L. C., Sipe, J. D., Ford, A. B., & Kushner, I. (1996) · Age and Ageing · doi:10.1093/ageing/25.3.224 · Cited by 167 · see citing works

Impaired production of proinflammatory cytokines in response to lipopolysaccharide (LPS) stimulation in elderly humans

Brüünsgaard, H., Pedersen, B. K., Schroll, M., Skinhøj, P., & Pedersen, B. K. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.01045.x · Cited by 158 · see citing works

Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice

Jang, S., Dilger, R. N., & Johnson, R. W. (2010) · Journal of Nutrition · doi:10.3945/jn.110.123273 · Cited by 154 · see citing works

The Genetics of Human Longevity

Capri, M., Salvioli, S., Sevini, F., Valensin, S., Celani, L., Monti, D., Pawelec, G., Benedictis, G. D., Gonos, E. S., & Franceschi, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.033 · Cited by 153 · see citing works

Inhibition of NFκB Activity through Maintenance of IκBα Levels Contributes to Dihydrotestosterone-mediated Repression of the Interleukin-6 Promoter

Keller, E. T., Chang, C., & Ershler, W. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26267 · Cited by 152 · see citing works

Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes

Giuliani, N., Sansoni, P., Girasole, G., Vescovini, R., Passeri, G., Passeri, M., & Pedrazzoni, M. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00220-5 · Cited by 151 · see citing works

Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker.

Goydos, J. S., Brumfield, A., Frezza, E., Booth, A., Lotze, M., & Carty, S. (1998) · Annals of Surgery · doi:10.1097/00000658-199803000-00012 · Cited by 160 · see citing works

Physiological Features of Aging Persons

Aalami, O. (2003) · Archives of Surgery · doi:10.1001/archsurg.138.10.1068 · Cited by 143 · see citing works

Aging and T-cell-mediated immunity

Chakravarti, B., & Abraham, G. N. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00009-3 · Cited by 142 · see citing works

Regulation of estrogen synthesis in postmenopausal women

Purohit, A., & Reed, M. J. (2002) · Steroids · doi:10.1016/s0039-128x(02)00046-6 · Cited by 139 · see citing works

Role of aromatase in sex steroid action

SIMPSON, E. R. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250149 · Cited by 134 · see citing works

Prediction of Mortality Risk in the Elderly

Störk, S., Feelders, R. A., van den Beld, A. W., Steyerberg, E. W., Savelkoul, H. F. J., Lamberts, S. W. J., Grobbee, D. E., & Bots, M. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.062 · Cited by 132 · see citing works

Breast Cancer and the Role of Cytokines in Regulating Estrogen Synthesis: An Emerging Hypothesis

Reed, M. J., & Purohit, A. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0314 · Cited by 132 · see citing works

Sarcopenia: Current treatments and new regenerative therapeutic approaches

Lo, J. C. Y., Kin Pong, U., Yiu, T. L., Ong, M. T., & Lee, W. (2020) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.04.002 · Cited by 133 · see citing works

Sarcopenia - Mechanisms and Treatments

Jones, T. E., Stephenson, K. W., King, J. G., Knight, K. R., Marshall, T. L., & Scott, W. B. (2009) · Journal of Geriatric Physical Therapy · doi:10.1519/00139143-200932020-00008 · Cited by 129 · see citing works

Morphology, mechanisms and pathology of musculoskeletal ageing

Freemont, A. J., & Hoyland, J. A. (2007) · The Journal of Pathology · doi:10.1002/path.2097 · Cited by 130 · see citing works

Expression of transcripts of interleukin-6 and related cytokines by human breast tumors, breast cancer cells, and adipose stromal cells

Crichton, M. B., Nichols, J. E., Zhao, Y., Bulun, S. E., & Simpson, E. R. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(96)03761-6 · Cited by 119 · see citing works

Age-Related Changes in the Osteogenic Differentiation Potential of Mouse Bone Marrow Stromal Cells

Zhang, W., Ou, G., Hamrick, M. W., Hill, W., Borke, J. L., Wenger, K., Chutkan, N. B., Yu, J. C.-K., Mi, Q., Isales, C. M., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080304 · Cited by 116 · see citing works

DHEA enhances effects of weight training on muscle mass and strength in elderly women and men

Villareal, D. T., & Holloszy, J. O. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00100.2006 · Cited by 116 · see citing works

Exercise-Induced Myokines can Explain the Importance of Physical Activity in the Elderly: An Overview

Kwon, J. H., Moon, K. M., & Min, K.-W. (2020) · Healthcare · doi:10.3390/healthcare8040378 · Cited by 116 · see citing works

Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?

Lin, L., & Sibille, E. L. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00110 · Cited by 115 · see citing works

Association of inflammation and cognition in the elderly: A systematic review and meta-analysis

Leonardo, S., & Fregni, F. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1069439 · Cited by 115 · see citing works

Senior Adult Oncology

Hurria, A., Browner, I. S., Cohen, H. J., Denlinger, C. S., deShazo, M., Extermann, M., Ganti, A. K., Holland, J. C., Holmes, H. M., Karlekar, M. B., et al. (2012) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2012.0019 · Cited by 114 · see citing works

Effects of oestrogen deprivation on interleukin-6 production by peripheral blood mononuclear cells of postmenopausal women

Rachoń, D., Myśliwska, J. M., Suchecka-Rachoń, K., Więckiewicz, J., & Myśliwski, A. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1720387 · Cited by 114 · see citing works

Inflammation in Schizophrenia: Cytokine Levels and Their Relationships to Demographic and Clinical Variables

Lee, E., Hong, S., Martin, A. S., Eyler, L. T., & Jeste, D. V. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.09.009 · Cited by 113 · see citing works

Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain

Currais, A., Fischer, W. H., Maher, P., & Schubert, D. (2017) · The FASEB Journal · doi:10.1096/fj.201601184 · Cited by 110 · see citing works

Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations

Miles, E. A., Rees, D., Banerjee, T., Cazzola, R., Lewis, S., Wood, R., Oates, R., Tallant, A., Cestaro, B., Yaqoob, P., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.002 · Cited by 112 · see citing works

Age-associated alterations in immune function and inflammation

Lewis, E. D., Wu, D., & Meydani, S. N. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110576 · Cited by 111 · see citing works

Cytokines and hormones as possible links between endocrinosenescence and immunosenescence

Straub, R. H. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00296-4 · Cited by 109 · see citing works

Oxidative biochemical markers; clues to understanding aging in long-lived species

Floyd, R. A., West, M., & Hensley, K. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00231-x · Cited by 106 · see citing works

Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status

Myśliwska, J. M., Bryl, E., Foerster, J., & Myśliwski, A. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00154-1 · Cited by 108 · see citing works

Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?

Feyaerts, A. F., & Luyten, W. H. M. L. (2020) · Nutrition · doi:10.1016/j.nut.2020.110948 · Cited by 107 · see citing works

The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-β1) levels in normal healthy blood donors

Young, D. G., Skibiński, G., Mason, J. I., & James, K. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.01003.x · Cited by 107 · see citing works

HEMATOPOIESIS AND CYTOKINES

Baraldi-Junkins, C. A., Beck, A. C., & Rothstein, G. (2000) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(05)70277-x · Cited by 105 · see citing works

Dehydroepiandrosterone and Diseases of Aging

WATSON, R. R., Huls, A., Araghinikuam, M., & Chung, S. (1996) · Drugs & Aging · doi:10.2165/00002512-199609040-00005 · Cited by 103 · see citing works

Optimal Hemodialysis Vascular Access in the Elderly Patient

MOIST, L. M., Lok, C. E., Vachharajani, T. J., Wang, X., Al‐Jaishi, A. A., Polkinghorne, K. R., Vazquez, M. A., & Lee, T. C. (2012) · Seminars in Dialysis · doi:10.1111/sdi.12037 · Cited by 103 · see citing works

Humoral immunity in aging

Paganelli, R., Scala, E., Quinti, I., & Ansotegui, I. J. (1994) · Aging Clinical and Experimental Research · doi:10.1007/bf03324229 · Cited by 103 · see citing works

Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey

Afifi, L., Danesh, M. J., Lee, K. M., Beroukhim, K., Farahnik, B., Ahn, R. S., Yan, D., Singh, R., Nakamura, M., Koo, J. Y. M., et al. (2017) · Dermatology and Therapy · doi:10.1007/s13555-017-0183-4 · Cited by 102 · see citing works

Antioxidants, Cytokines, and Influenza Infection in Aged Mice and Elderly Humans

Han, S. N., & Meydani, S. N. (2000) · The Journal of Infectious Diseases · doi:10.1086/315915 · Cited by 102 · see citing works

Serum interleukin-6 levels are higher in old age subjects with Alzheimer’s dementia

Boccardi, V., Baroni, M., Cecchetti, R., Scamosci, M., Bastiani, P., & Mecocci, P. (2021) · Geriatric Care · doi:10.4081/gc.2021.9423 · Cited by 2 · see citing works

Interleukin-6 and selected plasma proteins in healthy persons of different ages

Häger, K., Machein, U., Krieger, S., Platt, D., Seefried, G., & Bauer, J. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90066-3 · Cited by 172 · see citing works

Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer’s disease (DAT): Lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT

Bonaccorso, S., Lin, A., Song, C., Verkerk, R. M., Kenis, G., Bosmans, E., Scharpé, S., Vandewoude, M. F. J., Dossche, A., & Maes, M. H. J. (1998) · Aging Clinical and Experimental Research · doi:10.1007/bf03339794 · Cited by 62 · see citing works

Plasma cytokines profile in older subjects with late onset Alzheimer’s disease or vascular dementia

Zuliani, G., Ranzini, M., Guerra, G., Rossi, L., Munari, M. R., Zurlo, A., Volpato, S., Atti, A. R., Blè, A., & Fellin, R. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.02.008 · Cited by 234 · see citing works

Inflammatory markers in younger vs elderly normal volunteers and in patients with Alzheimer’s disease

Maes, M. H. J., Devos, N., Wauters, A., Demedts, P., Maurits, V., Neels, H. M., Bosmans, E., Altamura, C. A., Lin, A., Song, C., et al. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00016-3 · Cited by 110 · see citing works