Cited by 476Aging, Health, and DisabilityNutrition and Health in AgingFrailty in Older Adults

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The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly

Cohen, H. J., Pieper, C. F., Harris, T., Rao, K M. K, Currie, M. S.·1997·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/52a.4.m201

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Abstract

BACKGROUND: IL-6 is a multifunctional cytokine that has been shown to increase with age. METHODS: Plasma IL-6 was measured by ELISA in 1,727 community-dwelling elderly subjects whose blood was drawn during the third in-person survey of the Duke Established Populations for Epidemiologic Studies of the Elderly (EPESE). Demographics, functional status (disability), and disease states were determined. Correlations of these factors with IL-6 were analyzed with Spearman's Rho while differences between groups were assessed by Wilcoxon test. RESULTS: IL-6 levels were higher with age (p = .0001) even in this older population (> 70 years). There was a positive correlation between IL-6 and functional disability for each of the functional status measures (p = .0001), as well as a correlation between self-rated health and IL-6. Significantly higher median levels of IL-6 were found in subjects reporting prevalent cancer, heart attack, and high blood pressure, but not diabetes or arthritis. The association between age and functional status with high IL-6 remained when all other variables were controlled, in multivariable analysis. CONCLUSIONS: This association between increased plasma IL-6 levels and functional status suggests that dysregulation of IL-6 may be related to the functional disability seen with aging, and that IL-6 may be useful as a component of an overall marker of health.

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Authors: Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M. K., & Currie, M. S.
Affiliations: Duke University (US)
National Institutes of Health (US)
ORCID: Cohen, H. J.
Pieper, C. F.
Harris, T.
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 1997-07-01
Volume: 52A
Issue: 4
Pages: M201-M208
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/52a.4.m201
OpenAlex: W2149814390
Cited by: 476
References: 35
Citations by year: 2026: 4 · 2025: 5 · 2024: 18 · 2023: 14 · 2022: 13 · 2021: 20 · 2020: 23 · 2019: 15 · 2018: 14 · 2017: 13 · 2016: 12 · 2015: 18 · 2014: 15 · 2013: 25 · 2012: 18
FWCI: 18.48
Type: journal article
Language: en
Open access: closed
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01ag012102-011)
National Institute on Aging (5P60-AG11268, N01‐AG12102, P60AG011268)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords: interleukin-6, plasma cytokines, functional disability, community-dwelling older adults, aging, self-rated health, cancer, myocardial infarction, hypertension, health indicators
MeSH terms: Aged, Aging, Community Medicine, Enzyme-Linked Immunosorbent Assay, Female, Persons with Disabilities, Disabled Persons, Health Status, Humans, Male, Self-Assessment, Interleukin-6, Multivariate Analysis

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The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly

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