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Cited by 241Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model OrganismsAssisted Reproductive Technology and Twin Pregnancy

The DOI matches its Crossref record; 16 of the 17 references it cites were found in a registry or an index.

The Effect of Genetic Factors for Longevity: A Comparison of Identical and Fraternal Twins in the Swedish Twin Registry

Ljungquist, B., Berg, S., Lanke, J., McClearn, G. E., Pedersen, N. L.·1998·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
DOI 10.1093/gerona/53a.6.m441
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Abstract

BACKGROUND: The relative importance of genetic influences on longevity was studied on data from the population-based Swedish Twin Registry. METHODS: A sample of 3,656 identical and 6,849 like-sexed fraternal twin pairs was studied regarding mortality rates and within-pair similarity for age at death. Genetic and environmental contributions to variation in longevity, expressed by integrated mortality rates, were estimated from a subsample of 1,734 twin pairs reared together and 130 twin pairs reared apart from the cohorts born 1886 to 1900. RESULTS: The intraclass correlation coefficients suggested that the genetic effect was small, and, for males, perhaps absent. Among pairs in which both twins died relatively young and among pairs in which both twins lived until very old age, the variance in age at death seemed to have no genetic component. Model fitting procedures based on twins reared apart and twins reared together indicated that most of the variance in longevity was explained by environmental factors. CONCLUSIONS: Over the total age range examined, a maximum of around one third of the variance in longevity is attributable to genetic factors, and almost all of the remaining variance is due to nonshared, individual specific environmental factors. The evidence that genetic factors play a minor role depending upon age at death merits further examination.

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Metadata

Authors
Ljungquist, B., Berg, S., Lanke, J., McClearn, G. E., & Pedersen, N. L.
Affiliations
  • Jönköping University (SE)
  • Lund University (SE)
  • Pennsylvania State University (US)
  • Karolinska Institutet (SE)
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher
Oxford University Press (OUP)
Published
1998-11-01
Volume
53A
Issue
6
Pages
M441-M446
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
DOI
10.1093/gerona/53a.6.m441
OpenAlex
W2171801044
Cited by
241
References
17
Citations by year
2026: 1 · 2025: 19 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 12 · 2012: 15
FWCI
4.20
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG 08861)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
Keywords
longevity, genetic factors, heritability, monozygotic twins, dizygotic twins, mortality, age at death, nonshared environment, twins reared apart, Swedish Twin Registry, intraclass correlation coefficient
MeSH terms
Adult, Aged, Environment, Female, Humans, Longevity, Male, Middle Aged, Models, Biological, Mortality, Registries, Sweden, Twins, Dizygotic, Twins, Monozygotic

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