The DOI matches its Crossref record; 16 of the 17 references it cites were found in a registry or an index.
The Effect of Genetic Factors for Longevity: A Comparison of Identical and Fraternal Twins in the Swedish Twin Registry
Abstract
BACKGROUND: The relative importance of genetic influences on longevity was studied on data from the population-based Swedish Twin Registry. METHODS: A sample of 3,656 identical and 6,849 like-sexed fraternal twin pairs was studied regarding mortality rates and within-pair similarity for age at death. Genetic and environmental contributions to variation in longevity, expressed by integrated mortality rates, were estimated from a subsample of 1,734 twin pairs reared together and 130 twin pairs reared apart from the cohorts born 1886 to 1900. RESULTS: The intraclass correlation coefficients suggested that the genetic effect was small, and, for males, perhaps absent. Among pairs in which both twins died relatively young and among pairs in which both twins lived until very old age, the variance in age at death seemed to have no genetic component. Model fitting procedures based on twins reared apart and twins reared together indicated that most of the variance in longevity was explained by environmental factors. CONCLUSIONS: Over the total age range examined, a maximum of around one third of the variance in longevity is attributable to genetic factors, and almost all of the remaining variance is due to nonshared, individual specific environmental factors. The evidence that genetic factors play a minor role depending upon age at death merits further examination.
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“While genetic factors account for only 15–40% of lifespan variability [28,29,30,31,32], environmental exposures—including access to green spaces—play a dominant role in shaping aging trajectories.”
In the citing paper
“While genetic factors account for only 15–40% of lifespan variability [28,29,30,31,32], environmental exposures—including access to green spaces—play a dominant role in shaping aging trajectories.”
Citations
Cites
Genetic and Environmental Influences on Premature Death in Adult Adoptees
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Jinks, J. L., & Fulker, D. W. (1970) · Psychological Bulletin · doi:10.1037/h0029135 · Cited by 808
Longevity Is Moderately Heritable in a Sample of Danish Twins Born 1870-1880
McGue, M., Vaupel, J. W., Holm, N. V., & Harvald, B. (1993) · Journal of Gerontology · doi:10.1093/geronj/48.6.b237 · Cited by 364
Mortality Following Conjugal Bereavement and the Effects of a Shared Environment
Schaefer, C. A., Quesenberry, C. P., & Wi, S. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117387 · Cited by 176
Swedish Early Separated Twins: Identification and Characterization
Pedersen, N. L., Friberg, L., FLODERUS-MYRHED, B., McClearn, G. E., & Plomin, R. J. (1984) · Acta geneticae medicae et gemellologiae · doi:10.1017/s0001566000007285 · Cited by 149
Self-citationAbbott, M. H., Abbey, H., Bolling, D. R., Murphy, E. A., & Opitz, J. M. (1978) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320020202 · Cited by 59
Familial transmission of longevity
Bocquet‐Appel, J., & Jakobi, L. (1990) · Annals of Human Biology · doi:10.1080/03014469000000832 · Cited by 56
Family Patterns of Mortality and Life Span
Cohen, B. H. (1964) · The Quarterly Review of Biology · doi:10.1086/404164 · Cited by 55
Survival trends in a senescent twin population.
Jarvik, L. F., Falek, A., Kallmann, F. J., & Lorge, I. D. (1960) · PubMed Central · Cited by 55
PARENTAL SURVIVAL, AN INDEPENDENT PREDICTOR OF LONGEVITY IN MIDDLE-AGED PERSONS
Vandenbroucke, J. P., Matroos, A. W., HEIDE-WESSEL, C. V. D., & HEIDE, R. M. V. D. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113795 · Cited by 33
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Hjelmborg, J., Iachine, I. A., Skytthe, A., Vaupel, J. W., McGue, M. K., Koskenvuo, M. J., Kaprio, J. A., Pedersen, N. L., & Christensen, K. (2006) · Human Genetics · doi:10.1007/s00439-006-0144-y · Cited by 498
Self-citationFinch, C. E., & Ruvkun, G. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.435 · Cited by 446
Life-long sustained mortality advantage of siblings of centenarians
Perls, T. T., Wilmoth, J. R., Levenson, R., Shea-Drinkwater, M., Cohen, M., Bogan, H., Joyce, E., Brewster, S. J., Kunkel, L. M., & Puca, A. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122587599 · Cited by 378
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 372
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Metadata
- Authors
- Ljungquist, B., Berg, S., Lanke, J., McClearn, G. E., & Pedersen, N. L.
- Affiliations
- Jönköping University (SE)
- Lund University (SE)
- Pennsylvania State University (US)
- Karolinska Institutet (SE)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-11-01
- Volume
- 53A
- Issue
- 6
- Pages
- M441-M446
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2171801044
- Cited by
- 241
- References
- 17
- Citations by year
- 2026: 1 · 2025: 19 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 12 · 2012: 15
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 08861)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Keywords
- longevity, genetic factors, heritability, monozygotic twins, dizygotic twins, mortality, age at death, nonshared environment, twins reared apart, Swedish Twin Registry, intraclass correlation coefficient
- MeSH terms
- Adult, Aged, Environment, Female, Humans, Longevity, Male, Middle Aged, Models, Biological, Mortality, Registries, Sweden, Twins, Dizygotic, Twins, Monozygotic
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