Cited by 241Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model OrganismsAssisted Reproductive Technology and Twin Pregnancy

The DOI matches its Crossref record; 16 of the 17 references it cites were found in a registry or an index.

The Effect of Genetic Factors for Longevity: A Comparison of Identical and Fraternal Twins in the Swedish Twin Registry

Ljungquist, B., Berg, S., Lanke, J., McClearn, G. E., Pedersen, N. L.·1998·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/53a.6.m441

Open this paper in CoChat — free account

Abstract

BACKGROUND: The relative importance of genetic influences on longevity was studied on data from the population-based Swedish Twin Registry. METHODS: A sample of 3,656 identical and 6,849 like-sexed fraternal twin pairs was studied regarding mortality rates and within-pair similarity for age at death. Genetic and environmental contributions to variation in longevity, expressed by integrated mortality rates, were estimated from a subsample of 1,734 twin pairs reared together and 130 twin pairs reared apart from the cohorts born 1886 to 1900. RESULTS: The intraclass correlation coefficients suggested that the genetic effect was small, and, for males, perhaps absent. Among pairs in which both twins died relatively young and among pairs in which both twins lived until very old age, the variance in age at death seemed to have no genetic component. Model fitting procedures based on twins reared apart and twins reared together indicated that most of the variance in longevity was explained by environmental factors. CONCLUSIONS: Over the total age range examined, a maximum of around one third of the variance in longevity is attributable to genetic factors, and almost all of the remaining variance is due to nonshared, individual specific environmental factors. The evidence that genetic factors play a minor role depending upon age at death merits further examination.

Integrity signals

Registry

Crossref · 10.1093/gerona/53a.6.m441

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Genetic and Environmental Influences on Premature Death in Adult Adoptees
Sørensen, T. I. A., Nielsen, G. G., Andersen, P. K., & Teasdale, T. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803243181202 · Cited by 826
Comparison of the biometrical genetical, MAVA, and classical approaches to the analysis of the human behavior.
Jinks, J. L., & Fulker, D. W. (1970) · Psychological Bulletin · doi:10.1037/h0029135 · Cited by 808
Longevity Is Moderately Heritable in a Sample of Danish Twins Born 1870-1880
McGue, M., Vaupel, J. W., Holm, N. V., & Harvald, B. (1993) · Journal of Gerontology · doi:10.1093/geronj/48.6.b237 · Cited by 364
Mortality Following Conjugal Bereavement and the Effects of a Shared Environment
Schaefer, C. A., Quesenberry, C. P., & Wi, S. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117387 · Cited by 176
Swedish Early Separated Twins: Identification and Characterization
Pedersen, N. L., Friberg, L., FLODERUS-MYRHED, B., McClearn, G. E., & Plomin, R. J. (1984) · Acta geneticae medicae et gemellologiae · doi:10.1017/s0001566000007285 · Cited by 149
Self-citation
The familial component in longevity—A study of offspring of nonagenarians: III. Intrafamilial studies
Abbott, M. H., Abbey, H., Bolling, D. R., Murphy, E. A., & Opitz, J. M. (1978) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320020202 · Cited by 59
Familial transmission of longevity
Bocquet‐Appel, J., & Jakobi, L. (1990) · Annals of Human Biology · doi:10.1080/03014469000000832 · Cited by 56
Family Patterns of Mortality and Life Span
Cohen, B. H. (1964) · The Quarterly Review of Biology · doi:10.1086/404164 · Cited by 55
Survival trends in a senescent twin population.
Jarvik, L. F., Falek, A., Kallmann, F. J., & Lorge, I. D. (1960) · PubMed Central · Cited by 55
PARENTAL SURVIVAL, AN INDEPENDENT PREDICTOR OF LONGEVITY IN MIDDLE-AGED PERSONS
Vandenbroucke, J. P., Matroos, A. W., HEIDE-WESSEL, C. V. D., & HEIDE, R. M. V. D. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113795 · Cited by 33

Show all 17 references

Sorted by citations

Genetic influence on human lifespan and longevity
Hjelmborg, J., Iachine, I. A., Skytthe, A., Vaupel, J. W., McGue, M. K., Koskenvuo, M. J., Kaprio, J. A., Pedersen, N. L., & Christensen, K. (2006) · Human Genetics · doi:10.1007/s00439-006-0144-y · Cited by 498
Self-citation
The Genetics of Aging
Finch, C. E., & Ruvkun, G. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.435 · Cited by 446
Life-long sustained mortality advantage of siblings of centenarians
Perls, T. T., Wilmoth, J. R., Levenson, R., Shea-Drinkwater, M., Cohen, M., Bogan, H., Joyce, E., Brewster, S. J., Kunkel, L. M., & Puca, A. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122587599 · Cited by 378
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 372
T cells and aging
Pawelec, G. (1998) · Frontiers in bioscience · doi:10.2741/a266 · Cited by 357
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
Timmers, P. R., Mounier, N., Lall, K., Fischer, K., Ning, Z., Feng, X., Bretherick, A. D., Clark, D. W., eQTLGen Consortium, Agbessi, M., et al. (2019) · eLife · doi:10.7554/elife.39856 · Cited by 259
Genome-Wide Association
Taylor, K. D., Norris, J. M., & Rotter, J. I. (2007) · Diabetes · doi:10.2337/db07-1324 · Cited by 308
Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating
Ruby, J. G., Wright, K. M., Rand, K. A., Kermany, A., Noto, K., Curtis, D., Varner, N., Garrigan, D., Slinkov, D., Dorfman, I., et al. (2018) · Genetics · doi:10.1534/genetics.118.301613 · Cited by 263
Quantitative analysis of population-scale family trees with millions of relatives
Kaplanis, J., Gordon, A., Shor, T., Weissbrod, O., Geiger, D., Wahl, M., Gershovits, M., Markus, B., Sheikh, M., Gymrek, M., et al. (2018) · Science · doi:10.1126/science.aam9309 · Cited by 245
Improvement of Naturally Aged Skin With Vitamin A (Retinol)
Kafi, R., Kwak, H. S. R., Schumacher, W. E., Cho, S., Hanft, V. N., Hamilton, T. A., King, A. L., Neal, J. D., Varani, J., Fisher, G. J., et al. (2007) · Archives of Dermatology · doi:10.1001/archderm.143.5.606 · Cited by 247
Inheritance of human longevity in Iceland
Gudmundsson, H., Gudbjartsson, D. F., Kong, A., Guðbjartsson, H., Frigge, M., Gulcher, J. R., & Stefánsson, K. (2000) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200527 · Cited by 231
Gender-specific association between −1082 IL-10 promoter polymorphism and longevity
Lio, D., Scola, L., Crivello, A., Colonna‐Romano, G., Candore, G., Bonafè, M., Cavallone, L., Franceschi, C., & Caruso, C. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363827 · Cited by 227
Heritability of life span in the Old Order Amish
Mitchell, B. D., Hsueh, W., King, T. M., Pollin, T. I., Sorkin, J. D., Agarwala, R., Schäffer, A. A., & Shuldiner, A. R. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1483 · Cited by 201
Human models of aging and longevity
Cevenini, E., Invidia, L., Lescai, F., Salvioli, S., Tieri, P., Castellani, G., & Franceschi, C. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.9.1393 · Cited by 200
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
Lunetta, K. L., D’Agostino, R. B., Karasik, D., Benjamin, E. J., Guo, C., Govindaraju, R., Kiel, D. P., Kelly‐Hayes, M., Massaro, J. M., Pencina, M. J., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s13 · Cited by 193
Lifestyle Factors of People with Exceptional Longevity
Rajpathak, S. N., Liu, Y., Ben‐David, O., Reddy, S., Atzmon, G., Crandall, J. P., & Barzilai, N. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03498.x · Cited by 187
Siblings of Okinawan Centenarians Share Lifelong Mortality Advantages
Willcox, B. J., Willcox, D. C., He, Q., Curb, J. D., & Suzuki, M. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.4.345 · Cited by 169
Genetic and epigenetic regulation of human aging and longevity
Morris, B. J., Willcox, B. J., & Donlon, T. A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.039 · Cited by 140
If you would live long, choose your parents well
Cournil, A., & Kirkwood, T. B. L. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02306-x · Cited by 144
T cells and aging (update February 1999)
Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 140
Longevity Studies in GenomEUtwin
Skytthe, A., Pedersen, N. L., Kaprio, J. A., Stazi, M. A., Hjelmborg, J., Iachine, I. A., Vaupel, J. W., & Christensen, K. (2003) · Twin Research · doi:10.1375/136905203770326457 · Cited by 137
Self-citation
Immunogenetics, Gender, and Longevity
Candore, G., Balistreri, C. R., Listı̀, F., Grimaldi, M. P., Vasto, S., Colonna‐Romano, G., Franceschi, C., Lio, D., Caselli, G., & Caruso, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.051 · Cited by 129
The Genetics of Exceptional Human Longevity
Perls, T. T., Kunkel, L. M., & Puca, A. A. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.49283.x · Cited by 122
Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait
van den Berg, N., Rodríguez‐Girondo, M., van Dijk, I. K., Mourits, R. J., Mandemakers, K., Janssens, A. A. P. O., Beekman, M., Smith, K. R., & Slagboom, P. E. (2018) · Nature Communications · doi:10.1038/s41467-018-07925-0 · Cited by 114
Understanding the Determinants of Exceptional Longevity
Perls, T. T., & Terry, D. F. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-5_part_2-200309021-00013 · Cited by 110
Successful Aging: From Phenotype to Genotype
Glatt, S. J., Chayavichitsilp, P., Depp, C. A., Schork, N. J., & Jeste, D. V. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.015 · Cited by 107
Distributions of ACE and APOE Polymorphisms and Their Relations With Dementia Status in Korean Centenarians
Choi, Y. H., Kim, J.-H., Kim, D. K., Kim, J.-W., Kim, D., Lee, M. S., Kim, C. H., & Park, S. C. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.3.m227 · Cited by 103
Alcohol Use Disorder and Mortality Across the Lifespan
Kendler, K. S., Ohlsson, H., Sundquist, J., & Sundquist, K. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0360 · Cited by 105
Historical demography and longevity genetics: Back to the future
van den Berg, N., Beekman, M., Smith, K. R., Janssens, A. A. P. O., & Slagboom, P. E. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.06.005 · Cited by 93
Psychological resources protect health: 5-year survival and immune function among HIV-infected women from four US cities
Ickovics, J. R., Milan, S., BOLAND, R. J., Schoenbaum, E. E., Schuman, P. C., & Vlahov, D. (2006) · AIDS · doi:10.1097/01.aids.0000244204.95758.15 · Cited by 89
Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches
Kudryashova, K. S., Burka, K., Kulaga, A. Y., Vorobyeva, N. S., & Kennedy, B. K. (2020) · PROTEOMICS · doi:10.1002/pmic.201900408 · Cited by 95
Searching for Human Longevity Genes: The Future History of Gerontology in the Post-genomic Era
Barzilai, N., & Shuldiner, A. R. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.2.m83 · Cited by 86
Context-dependent genetic architecture of Drosophila life span
Huang, W., Campbell, T., Carbone, M. A., Jones, W. E., Unselt, D., Anholt, R., & Mackay, T. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000645 · Cited by 72
Lifespan in captive baboons is heritable
Martin, L. J., Mahaney, M. C., Bronikowski, A. M., Carey, K. D., Dyke, B., & Comuzzie, A. G. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00083-0 · Cited by 77
Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data
Caruso, C., Candore, G., Romano, G. C., Lio, D., Bonafè, M., Valensin, S., & Franceschi, C. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00255-4 · Cited by 77
Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of “Aging,” “Life Span,” and “Longevity”
Sebastiani, P., Nussbaum, L. S., Andersen, S. L., Black, M. J., & Perls, T. T. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv020 · Cited by 74
Dementia-free centenarians
Perls, T. T. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.08.015 · Cited by 74
Genetics of exceptional longevity
Perls, T. T., & Terry, D. F. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00098-6 · Cited by 73
Role of sirtuins, calorie restriction and physical activity in aging
Corbi, G. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/417 · Cited by 66
Bitter Taste Receptor Polymorphisms and Human Aging
Campa, D., Rango, F. D., Carrai, M., Crocco, P., Montesanto, A., Canzian, F., Rose, G., Rizzato, C., Passarino, G., & Barale, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045232 · Cited by 66
Caloric restriction and longevity: Effects of reduced body temperature
Carrillo, A. E., & Flouris, A. D. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.001 · Cited by 64
The genetics of exceptional human longevity
Perls, T. T., Kunkel, L. M., & Puca, A. A. (2002) · Journal of Molecular Neuroscience · doi:10.1007/s12031-002-0039-x · Cited by 64
Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population
Lio, D., Balistreri, C. R., Colonna‐Romano, G., Motta, M., Franceschi, C., Malaguarnera, M., Candore, G., & Caruso, C. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363823 · Cited by 62
A Prospective Analysis of Genetic Variants Associated with Human Lifespan
Wright, K. M., Rand, K. A., Kermany, A. R., Noto, K., Curtis, D., Garrigan, D., Slinkov, D., Dorfman, I., Granka, J. M., Byrnes, J., et al. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.119.400448 · Cited by 63
Links between thermoregulation and aging in endotherms and ectotherms
Flouris, A. D., & Piantoni, C. (2014) · Temperature · doi:10.4161/23328940.2014.989793 · Cited by 68
Extended maternal age at birth of last child and women’s longevity in the Long Life Family Study
Sun, F. X., Sebastiani, P., Schupf, N., Bae, H. T., Andersen, S. L., McIntosh, A., Abel, H., Elo, I. T., & Perls, T. T. (2014) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000276 · Cited by 60
Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E
Drenos, F., & Kirkwood, T. B. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010022 · Cited by 59
Heritability Analysis of Life Span in a Semi-isolated Population Followed Across Four Centuries Reveals the Presence of Pleiotropy Between Life Span and Reproduction
Gögele, M., Pattaro, C., Fuchsberger, C., Minelli, C., Pramstaller, P. P., & Wjst, M. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq163 · Cited by 57
Regional distribution of longevity population and chemical characteristics of natural water in Xinjiang, China
Liu, Y., Luo, K., Lin, X.-X., Gao, X., Ni, R., Wang, S., & Tian, X. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.11.134 · Cited by 55
“Positive biology”: the centenarian lesson
Caruso, C., Passarino, G., Puca, A. A., & Scapagnini, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-5 · Cited by 52
Mortality and Apolipoprotein E in Hispanic, African-American, and Caucasian elders
Lee, J. H., Tang, M., Schupf, N., Stern, Y., Jacobs, D. M., Tycko, B., & Mayeux, R. P. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1528 · Cited by 51
DNA Methylation and Epigenotypes
Holliday, R. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0144-x · Cited by 51
The evolution of aging and lifespan
Li, S., Vázquez, J. M., & Sudmant, P. H. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.08.005 · Cited by 56
Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs
Föhr, T., Waller, K. L., Viljanen, A., Sanchez, R., Ollikainen, M., Rantanen, T., Kaprio, J. A., & Sillanpää, E. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01112-7 · Cited by 51
Lipoprotein Metabolism in Japanese Centenarians: Effects of Apolipoprotein E Polymorphism and Nutritional Status
Arai, Y., Hirose, N., Nakazawa, S., Yamamura, K., Shimizu, K., Takayama, M., Ebihara, Y., Osono, Y., & Homma, S. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.4911234.x · Cited by 49
Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity
Montesanto, A., Dato, S., Bellizzi, D., Rose, G., & Passarino, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-6 · Cited by 49
Evidence of sex–linked effects on the inheritance of human longevity: a population–based study in the Valserine valley (French Jura), 18–20th centuries
Cournil, A., Legay, J.-M., & Schächter, F. (2000) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2000.1105 · Cited by 46
Economic level and human longevity: Spatial and temporal variations and correlation analysis of per capita GDP and longevity indicators in China
Wang, S., Luo, K., Liu, Y., Zhang, S., Lin, X.-X., Ni, R., Tian, X., & Gao, X. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.03.004 · Cited by 47
The Genomic Basis of Postponed Senescence in Drosophila melanogaster
Carnes, M. U., Campbell, T. G., Huang, W., Butler, D. G., Carbone, M. A., Duncan, L. H., Harbajan, S. V., King, E. M., Peterson, K. R., Weitzel, A. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138569 · Cited by 49
Genetic and Environmental Influences on Decline in Biobehavioral Markers of Aging
Finkel, D., Pedersen, N. L., Reynolds, C. A., Berg, S., Fairé, U. D., & Svartengren, M. (2003) · Behavior Genetics · doi:10.1023/a:1022549700943 · Cited by 46
Self-citation
Nuclear and Mitochondrial DNA Repair in Selected Eukaryotic Aging Model Systems
Gredilla, R., Garm, C., & Stevnsner, T. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/282438 · Cited by 44
Genealogical data and the biodemography of human longevity
Gavrilov, L. A., Gavrilova, N. S., Olshansky, S. J., & Carnes, B. A. (2002) · Biodemography and Social Biology · doi:10.1080/19485565.2002.9989056 · Cited by 42
Effects of environmental factors on the longevous people in China
Lv, J., Wang, W., & Li, Y. (2010) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2010.10.012 · Cited by 42
Genome-Wide Scan for a Healthy Aging Phenotype Provides Support for a Locus Near D4S1564 Promoting Healthy Aging
Reed, T., Dick, D. M., Uniacke, S. K., Foroud, T., & Nichols, W. C. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.3.b227 · Cited by 42
Genetic and Environmental Influences on Exceptional Longevity and the AGE Nomogram
Perls, T. T. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02077.x · Cited by 40
Genetic Epidemiologic Studies on Age-specified Traits
NIA Aging and Genetic Epidemiology Working Group (2000) · American Journal of Epidemiology · doi:10.1093/aje/152.11.1003 · Cited by 40
Precedents for the Biological Control of Aging: Experimental Postponement, Prevention, and Reversal of Aging Processes
Fahy, G. M. (2010) · Springer eBooks · doi:10.1007/978-90-481-3999-6_6 · Cited by 39
Heritability of Life Span Is Largely Sex Limited in Drosophila
Lehtovaara, A., Schielzeth, H., Flis, I., & Friberg, U. (2013) · The American Naturalist · doi:10.1086/673296 · Cited by 40
Human longevity and common variations in the LMNA gene: a meta‐analysis
Conneely, K. N., Capell, B. C., Erdos, M. R., Sebastiani, P., Solovieff, N., Swift, A. J., Baldwin, C. T., Budagov, T., Barzilai, N., Atzmon, G., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00808.x · Cited by 40
Spatio-temporal distribution of human lifespan in China
Wang, S., Luo, K., & Liu, Y. (2015) · Scientific Reports · doi:10.1038/srep13844 · Cited by 40
Exploring the genetics of longevity in the Old Order Amish
Sorkin, J. D., Post, W. S., Pollin, T. I., O’Connell, J. R., Mitchell, B. D., & Shuldiner, A. R. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.027 · Cited by 37
Genetics of Human Aging: The Search for Genes Contributing to Human Longevity and Diseases of the Old
Slagboom, P. E., Heijmans, B. T., Beekman, M., Westendorp, R. G. J., & Meulenbelt, I. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06635.x · Cited by 36
Heritability of intrinsic human life span is about 50% when confounding factors are addressed
Shenhar, B., Pridham, G., Oliveira, T. L. D., Yang, Y., Raz, N., Deelen, J., Hägg, S., & Alon, U. (2026) · Science · doi:10.1126/science.adz1187 · Cited by 48
Association between social relationships and survival of Swiss octogenarians. A five-year prospective, population-based study
Guilley, E., Pin, S., Spini, D., d’Épinay, C. L., Herrmann, F. R., & Michel, J. (2005) · Aging Clinical and Experimental Research · doi:10.1007/bf03324632 · Cited by 33
Extreme Longevity: Analysis of the Direct or Indirect Influence of Environmental Factors on Old, Nonagenarians, and Centenarians in Cilento, Italy
Aliberti, S. M., De Caro, F., Funk, R. H. W., Schiavo, L., Gonnella, J., Boccia, G., & Capunzo, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031589 · Cited by 33
Genetic Variation and Human Aging: Progress and Prospects
Melzer, D. R., Hurst, A. J., & Frayling, T. M. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.3.301 · Cited by 35
Principles of Biodemography with special reference to Human Longevity
Judge, D. S., & Carey, J. R. (2001) · Population · doi:10.3917/popu.p2001.13n1.0040 · Cited by 33
Genetics of human longevity: From variants to genes to pathways
Smulders, L., & Deelen, J. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13740 · Cited by 41
Stem cells and aging from a quasi‐immortal point of view
Böhm, A.-M., Rosenstiel, P. C., & Bosch, T. C. G. (2013) · BioEssays · doi:10.1002/bies.201300075 · Cited by 33
Genetic Influences on Life Span and Its Relationship to Personality
Mosing, M. A., Medland, S. E., McRae, A. F., Landers, J. G., Wright, M. J., & Martin, N. G. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182385784 · Cited by 35
Keeping up with the Red Queen: the pace of aging as an adaptation
Lenárt, P., & Vašků, J. B. (2016) · Biogerontology · doi:10.1007/s10522-016-9674-4 · Cited by 31
The genetic component of human longevity: analysis of the survival advantage of parents and siblings of Italian nonagenarians
Montesanto, A., Latorre, V., Giordano, M., Martino, C., Domma, F., & Passarino, G. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.40 · Cited by 30
I405V polymorphism of the cholesteryl ester transfer protein (CETP) gene in young and very old people
Vergani, C., Lucchi, T. A., Caloni, M., Ceconi, I., Calabresi, C., Scurati, S., & Arosio, B. (2005) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2005.10.008 · Cited by 31
The heritability of cause‐specific mortality: a correlated gamma‐frailty model applied to mortality due to respiratory diseases in Danish twins born 1870–1930
Wienke, A., Holm, N. V., Christensen, K., Skytthe, A., Vaupel, J. W., & Yashin, A. I. (2003) · Statistics in Medicine · doi:10.1002/sim.1669 · Cited by 31
Drug abuse-associated mortality across the lifespan: a population-based longitudinal cohort and co-relative analysis
Kendler, K. S., Ohlsson, H., Sundquist, K., & Sundquist, J. (2017) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-017-1398-5 · Cited by 28
The Power of Environment: A Comprehensive Review of the Exposome's Role in Healthy Aging, Longevity, and Preventive Medicine-Lessons from Blue Zones and Cilento
Aliberti, S. M., & Capunzo, M. (2025) · Nutrients · doi:10.3390/nu17040722 · Cited by 29
“Additionally, While genetic factors account for only 15–40% of lifespan variability [28–32], environmental exposures—including access to green spaces—play a dominant role in shaping aging trajectories. access to mineral-rich water sources observed in longevity regions like Cilento and Hunza, has…”
Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans
Kinser, H. E., Mosley, M. C., Plutzer, I. B., & Pincus, Z. (2021) · eLife · doi:10.7554/elife.65026 · Cited by 29
Preservation of cognitive and functional ability as markers of longevity
Schupf, N., Costa, R., Tang, M., Andrews, H., Tycko, B., Lee, J. H., & Mayeux, R. P. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.010 · Cited by 27
Longevity and Correlated Frailty in Multigenerational Families
Garibotti, G., Smith, K. R., Kerber, R. A., & Boucher, K. M. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.12.1253 · Cited by 27
Heritability and Validity of Healthy Physical Aging (Wellness) in Elderly Male Twins
Reed, T., & Dick, D. M. (2003) · Twin Research · doi:10.1375/136905203765693889 · Cited by 27
Revista Española de Geriatría y Gerontología
Santos, R. P., Torres, C. F., Martín‐Arranz, M. D., de Parga, J. M. S., & Martínez, M. A. (2016) · Cited by 26
Genome Survey for Loci That Influence Successful Aging: Sample Characterization, Method Validation, and Initial Results for the Y Chromosome
Zubenko, G. S., Stiffler, J. S., Hughes, H. B., Fatigati, M. J., & Zubenko, W. N. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200209000-00016 · Cited by 26
A new biodemographic model to explain the trajectory of mortality
Robine, J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00249-7 · Cited by 27
Where do people live longer and shorter lives? An ecological study of old-age survival across 4404 small areas from 18 European countries
Ribeiro, A. I., Krainski, E. T., Carvalho, M. S., & de Pina, M. D. F. (2016) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2015-206827 · Cited by 25
Genetic influences on life span and survival among elderly African‐Americans, Caribbean Hispanics, and Caucasians
Lee, J. H., Flaquer, A., Costa, R., Andrews, H., Cross, P. S., Lantigua, R., Schupf, N., Tang, M., & Mayeux, R. P. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30062 · Cited by 25
Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits
Kulminski, A. M., Arbeev, K. G., Christensen, K., Mayeux, R. P., Newman, A. B., Province, M. A., Hadley, E. C., Rossi, W. K., Perls, T. T., Elo, I. T., et al. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.03.006 · Cited by 23
Mechanisms underlying familial aggregation of exceptional health and survival: A three‐generation cohort study
Christensen, K., Wojczynski, M. K., Pedersen, J. K., Larsen, L. A., Kløjgaard, S., Skytthe, A., McGue, M. K., Vaupel, J. W., & Province, M. A. (2020) · Aging Cell · doi:10.1111/acel.13228 · Cited by 22
Register-based research on twins
Christensen, K., Kyvik, K. O., Holm, N. V., & Skytthe, A. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494811399170 · Cited by 21
Examining Supportive Evidence for Psychosocial Theories of Aging within the Oral History Narratives of Centenarians
Heinz, M. S., Cone, N., da Rosa, G., Bishop, A. J., & Finchum, T. (2017) · Societies · doi:10.3390/soc7020008 · Cited by 22
Regional Distribution of Longevity Population and Elements in Drinking Water in Jiangjin District, Chongqing City, China
Liu, Y., Yuan, Y., & Luo, K. (2017) · Biological Trace Element Research · doi:10.1007/s12011-017-1159-z · Cited by 22

Authors: Ljungquist, B., Berg, S., Lanke, J., McClearn, G. E., & Pedersen, N. L.
Affiliations: Jönköping University (SE)
Lund University (SE)
Pennsylvania State University (US)
Karolinska Institutet (SE)
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 1998-11-01
Volume: 53A
Issue: 6
Pages: M441-M446
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/53a.6.m441
OpenAlex: W2171801044
Cited by: 241
References: 17
Citations by year: 2026: 1 · 2025: 19 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 12 · 2012: 15
FWCI: 4.20
Type: journal article
Language: en
Open access: closed
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 08861)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
Keywords: longevity, genetic factors, heritability, monozygotic twins, dizygotic twins, mortality, age at death, nonshared environment, twins reared apart, Swedish Twin Registry, intraclass correlation coefficient
MeSH terms: Adult, Aged, Environment, Female, Humans, Longevity, Male, Middle Aged, Models, Biological, Mortality, Registries, Sweden, Twins, Dizygotic, Twins, Monozygotic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Effect of Genetic Factors for Longevity: A Comparison of Identical and Fraternal Twins in the Swedish Twin Registry

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks