The Genetics of Aging

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works

Introduction to Quantitative Genetics

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A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works

Oxidative Stress, Caloric Restriction, and Aging

Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133 · see citing works

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.

Alessi, D., James, S., Downes, C., Holmes, A. B., Gaffney, P., Reese, C., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 3,047 · see citing works

Mechanism of activation of protein kinase B by insulin and IGF‐1.

Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 2,985 · see citing works

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935 · see citing works

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works

Why do we age?

Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774 · see citing works

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712 · see citing works

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630 · see citing works

Gene expression profile of aging and its retardation by caloric restriction

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473 · see citing works

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436 · see citing works

Genetic pathways that regulate ageing in model organisms

Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296 · see citing works

An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., & Hafen, E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00068-9 · Cited by 1,255 · see citing works

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Kulkarni, R., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., & Kahn, C. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80546-2 · Cited by 1,139 · see citing works

Genetic associations with human longevity at the APOE and ACE loci

Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., & Cohen, D. (1994) · Nature Genetics · doi:10.1038/ng0194-29 · Cited by 1,095 · see citing works

Dwarf mice and the ageing process

Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091 · see citing works

Gene-expression profile of the ageing brain in mice

Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055 · see citing works

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

Lebovitz, R. M., Zhang, H., Vogel, H., Cartwright, J., Dionne, L., Lu, N., Huang, S., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9782 · Cited by 1,023 · see citing works

The genetics of caloric restriction in Caenorhabditis elegans

Lakowski, B., & Hekimi, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13091 · Cited by 967 · see citing works

Neurobiology of the <i>Caenorhabditis elegans</i> Genome

Bargmann, C. I. (1998) · Science · doi:10.1126/science.282.5396.2028 · Cited by 929 · see citing works

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P., Wallace, D. C., Malfroy, B., Doctrow, S. R., & Lithgow, G. J. (2000) · Science · doi:10.1126/science.289.5484.1567 · Cited by 913 · see citing works

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

Morris, J. Z., Tissenbaum, H. A., & Ruvkun, G. (1996) · Nature · doi:10.1038/382536a0 · Cited by 891 · see citing works

The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900

Herskind, A. M., McGue, M., Holm, N. V., Sørensen, T. I. A., Harvald, B., & Vaupel, J. W. (1996) · Human Genetics · doi:10.1007/bf02185763 · Cited by 879 · see citing works

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D. (2001) · Science · doi:10.1126/science.1059497 · Cited by 874 · see citing works

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

Lithgow, G. J., White, T. M., Melov, S., & Johnson, T. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7540 · Cited by 862 · see citing works

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

Parkes, T. L., Elia, A., Dickinson, D., Hilliker, A. J., Phillips, J. P., & Boulianne, G. L. (1998) · Nature Genetics · doi:10.1038/534 · Cited by 862 · see citing works

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

Lin, Y.-J., Seroude, L., & Benzer, S. (1998) · Science · doi:10.1126/science.282.5390.943 · Cited by 804 · see citing works

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B*

Rena, G., Guo, S., Cichy, S. C., Unterman, T., & Cohen, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17179 · Cited by 787 · see citing works

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

Tang, E., Núñez, G., Barr, F. G., & Guan, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.16741 · Cited by 761 · see citing works

The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans

Honda, Y., & Honda, S. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.11.1385 · Cited by 730 · see citing works

Aging and resistance to oxidative damage in Caenorhabditis elegans.

Larsen, P. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8905 · Cited by 722 · see citing works

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

Gems, D., Sutton, A. J., Sundermeyer, M. L., Albert, P. S., King, K. V., Edgley, M. L., Larsen, P. L., & Riddle, D. L. (1998) · Genetics · doi:10.1093/genetics/150.1.129 · Cited by 718 · see citing works

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factorPreprint

Paradis, S., & Ruvkun, G. (1998) · Genes & Development · doi:10.1101/gad.12.16.2488 · Cited by 711 · see citing works

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.

Ishii, N., Fujii, M., Hartman, P. S., Tsuda, M., Yasuda, K., Senoo-Matsuda, N., Yanase, S., Ayusawa, D., & Suzuki, K. (1998) · Nature · doi:10.1038/29331 · Cited by 687 · see citing works

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

Wolkow, C. A., Kimura, K. D., Lee, M. S., & Ruvkun, G. (2000) · Science · doi:10.1126/science.290.5489.147 · Cited by 681 · see citing works

Regulation of DAF-2 receptor signaling by human insulin and ins-1 , a member of the unusually large and diverse C. elegans insulin gene familyPreprint

Pierce, S. B., Costa, M. A., Wisotzkey, R. G., Devadhar, S., Homburger, S. A., Buchman, A. R., Ferguson, K. C., Heller, J., Platt, D., Pasquinelli, A. E., et al. (2001) · Genes & Development · doi:10.1101/gad.867301 · Cited by 639 · see citing works

Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant

Sze, J. Y., Victor, M., Loer, C. M., Shi, Y., & Ruvkun, G. (2000) · Nature · doi:10.1038/35000609 · Cited by 619 · see citing works

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice ¹

Coschigano, K. T., Clemmons, D., Bellush, L. L., & Kopchick, J. J. (2000) · Endocrinology · doi:10.1210/endo.141.7.7586 · Cited by 611 · see citing works

Genes that regulate both development and longevity in Caenorhabditis elegans.

Larsen, P. L., Albert, P. S., & Riddle, D. L. (1995) · Genetics · doi:10.1093/genetics/139.4.1567 · Cited by 584 · see citing works

Longevity, senescence, and the genome

Johnson, T. E. (1992) · Cell · doi:10.1016/0092-8674(92)90463-m · Cited by 575 · see citing works

Regulation of lifespan by sensory perception in Caenorhabditis elegans

Apfeld, J., & Kenyon, C. (1999) · Nature · doi:10.1038/45544 · Cited by 573 · see citing works

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

Guo, S., Rena, G., Cichy, S. B., He, X., Cohen, P., & Unterman, T. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17184 · Cited by 541 · see citing works

Control of C. elegans Larval Development by Neuronal Expression of a TGF-β Homolog

Ren, P., Lim, C., Johnsen, R. C., Albert, P. S., Pilgrim, D. B., & Riddle, D. L. (1996) · Science · doi:10.1126/science.274.5291.1389 · Cited by 532 · see citing works

Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

Rogina, B., Reenan, R. A., Nilsen, S. P., & Helfand, S. L. (2000) · Science · doi:10.1126/science.290.5499.2137 · Cited by 506 · see citing works

Genetics of Aging

Finch, C. E., & Tanzi, R. E. (1997) · Science · doi:10.1126/science.278.5337.407 · Cited by 485 · see citing works

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

Nakae, J., Park, B., & Accili, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.15982 · Cited by 474 · see citing works

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

Ogg, S., & Ruvkun, G. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80303-2 · Cited by 454 · see citing works

A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

Klass, M. R. (1983) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(83)90082-9 · Cited by 449 · see citing works

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

Dorman, J. B., Albinder, B., Shroyer, T., & Kenyon, C. J. (1995) · Genetics · doi:10.1093/genetics/141.4.1399 · Cited by 449 · see citing works

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegansPreprint

Paradis, S., Ailion, M., Toker, A., Thomas, J. H., & Ruvkun, G. (1999) · Genes & Development · doi:10.1101/gad.13.11.1438 · Cited by 428 · see citing works

Control of Larval Development by Chemosensory Neurons in Caenorhabditis elegans

Bargmann, C. I., & Horvitz, H. R. (1991) · Science · doi:10.1126/science.2006412 · Cited by 405 · see citing works

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

Gottlieb, S., & Ruvkun, G. (1994) · Genetics · doi:10.1093/genetics/137.1.107 · Cited by 387 · see citing works

Hormones and the physiological architecture of life history evolution

Finch, C. E., & Rose, M. R. (1995) · The Quarterly Review of Biology · doi:10.1086/418864 · Cited by 376 · see citing works

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

Estevez, M., Attisano, L., Wrana, J. L., Albert, P. S., Massagué, J., & Riddle, D. L. (1993) · Nature · doi:10.1038/365644a0 · Cited by 369 · see citing works

Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin

Granner, D. K., Andreone, T. L., Sasaki, K., & BEALE, E. G. (1983) · Nature · doi:10.1038/305549a0 · Cited by 362 · see citing works

Genes Control the Cessation of a Woman’s Reproductive Life: A Twin Study of Hysterectomy and Age at Menopause1

Snieder, H., MacGregor, A. J., & Spector, T. D. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4890 · Cited by 359 · see citing works

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans

Tissenbaum, H. A., & Ruvkun, G. (1998) · Genetics · doi:10.1093/genetics/148.2.703 · Cited by 354 · see citing works

Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR

Schmoll, D., Walker, K. S., Alessi, D. R., Grempler, R., Burchell, A., Guo, S., Walther, R., & Unterman, T. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003616200 · Cited by 349 · see citing works

Genotype-Environment Interaction for Quantitative Trait Loci Affecting Life Span in Drosophila melanogaster

Vieira, C. P., PASYUKOVA, E. G., Zeng, Z., Hackett, J. B., Lyman, R. F., & Mackay, T. F. C. (2000) · Genetics · doi:10.1093/genetics/154.1.213 · Cited by 340 · see citing works

Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

Takagi, Y., Mitsui, A., Nishiyama, A., Nozaki, K., Sono, H., Gon, Y., Hashimoto, N., & Yodoi, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4131 · Cited by 337 · see citing works

APOE genotype predicts when — not whether — one is predisposed to develop Alzheimer disease

Meyer, M. R., Tschanz, J. T., Norton, M. C., Welsh-Bohmer, K. A., Steffens, D. C., Wyse, B. W., & Breitner, J. C. S. (1998) · Nature Genetics · doi:10.1038/1206 · Cited by 335 · see citing works

Age and growth estimates of bowhead whales (Balaena mysticetus) via aspartic acid racemization

George, J. C., Bada, J. L., Zeh, J. E., et al. (1999) · Canadian Journal of Zoology · doi:10.1139/z99-015 · Cited by 328 · see citing works

A Transmembrane Guanylyl Cyclase (DAF-11) and Hsp90 (DAF-21) Regulate a Common Set of Chemosensory Behaviors in Caenorhabditis elegans

Birnby, D., Link, E. M., Vowels, J. J., Tian, H., Colacurcio, P. L., & Thomas, J. H. (2000) · Genetics · doi:10.1093/genetics/155.1.85 · Cited by 328 · see citing works

Chemosensory Neurons Function in Parallel to Mediate a Pheromone Response in C. elegans

Schackwitz, W., Inoue, T., & Thomas, J. H. (1996) · Neuron · doi:10.1016/s0896-6273(00)80203-2 · Cited by 314 · see citing works

Selection on stress resistance increases longevity in Drosophila melanogaster

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daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

Georgi, L. L., Albert, P. S., & Riddle, D. L. (1990) · Cell · doi:10.1016/0092-8674(90)90475-t · Cited by 297 · see citing works

CLK‐1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

Felkai, S., Ewbank, J. J., Lemieux, J., Labbé, J. ‐., Brown, G. G., & Hekimi, S. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1783 · Cited by 291 · see citing works

Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin

Hall, R. K., Yamasaki, T., Kučera, T., Waltner-Law, M. E., O’Brien, R. M., & Granner, D. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004898200 · Cited by 283 · see citing works

Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate

Voorhies, W. A. V., & Ward, S. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11399 · Cited by 282 · see citing works

Chance, development, and aging

de Grey, A. D. N. J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00123-1 · Cited by 281 · see citing works

Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans.

Thomas, J. H., Birnby, D., & Vowels, J. J. (1993) · Genetics · doi:10.1093/genetics/134.4.1105 · Cited by 280 · see citing works

Genes Control the Cessation of a Woman's Reproductive Life: A Twin Study of Hysterectomy and Age at Menopause

Snieder, H. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.6.1875 · Cited by 276 · see citing works

Regulation of Interneuron Function in the C. elegans Thermoregulatory Pathway by the ttx-3 LIM Homeobox Gene

Hobert, O., Mori, I., Yamashita, Y., Honda, H., Ohshima, Y., Liu, Y., & Ruvkun, G. (1997) · Neuron · doi:10.1016/s0896-6273(00)80944-7 · Cited by 262 · see citing works

Lessons from human progeroid syndromes

Martin, G. M., & Oshima, J. (2000) · Nature · doi:10.1038/35041705 · Cited by 261 · see citing works

Overexpression of human copper,zinc-superoxide dismutase (SOD1) prevents postischemic injury

Wang, P., Chen, H., Qin, H., Sankarapandi, S., Bêcher, M. W., Wong, P. C., & Zweier, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4556 · Cited by 258 · see citing works

The Effect of Genetic Factors for Longevity: A Comparison of Identical and Fraternal Twins in the Swedish Twin Registry

Ljungquist, B., Berg, S., Lanke, J., McClearn, G. E., & Pedersen, N. L. (1998) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/53a.6.m441 · Cited by 241 · see citing works

Middle-aged mothers live longer

Perls, T. T., Alpert, L., & Fretts, R. C. (1997) · Nature · doi:10.1038/38148 · Cited by 240 · see citing works

Inheritance of human longevity in Iceland

Gudmundsson, H., Gudbjartsson, D. F., Kong, A., Guðbjartsson, H., Frigge, M., Gulcher, J. R., & Stefánsson, K. (2000) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200527 · Cited by 233 · see citing works

A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process.

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Ubiquitous overexpression of CuZn superoxide dismutase does not extendlife span in mice

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PREMATURE OVARIAN FAILURE

Kalantaridou, S., Davis, S. R., & Nelson, L. M. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70051-7 · Cited by 205 · see citing works

Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: Apolipoprotein E gene is a ?frailty gene,? not a ?longevity gene?

Gerdes, L. U., Jeune, B., Andersen‐Ranberg, K., Nybo, H., & Vaupel, J. W. (2000) · Genetic Epidemiology · doi:10.1002/1098-2272(200010)19:3 · Cited by 204 · see citing works

The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathwayPreprint

Patterson, G. I., Koweek, A., Wong, A. C. K., Liu, Y., & Ruvkun, G. (1997) · Genes & Development · doi:10.1101/gad.11.20.2679 · Cited by 201 · see citing works

A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants

Jonassen, T., Larsen, P. L., & Clarke, C. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.421 · Cited by 197 · see citing works

The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction

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Mutations in the <i>WRN</i> Gene in Mice Accelerate Mortality in a p53-Null Background

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Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy

Shefner, J. M., Reaume, A. G., Flood, D. G., Scott, R. W., Kowall, N. W., Ferrante, R. J., Siwek, D. F., Upton-Rice, M. N., & Brown, R. H. (1999) · Neurology · doi:10.1212/wnl.53.6.1239 · Cited by 184 · see citing works

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