The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Ubiquitous overexpression of CuZn superoxide dismutase does not extendlife span in mice
Abstract
Oxidative damage has been implicated in the aging process and in a number of degenerative diseases. To investigate the role of oxygen radicals in the aging process in mammals, the life spans of transgenic mice on a CD-1 background expressing increased levels of CuZn superoxide dismutase (CuZnSOD), the enzyme that metabolizes superoxide radicals, were determined. Homozygous transgenic mice with a two- to five-fold elevation of CuZnSOD in various tissues showed a slight reduction of life span, whereas hemizygous mice with a 15- to 3-fold increase of CuZnSOD showed no difference in life span from that of the nontransgenic littermate controls. The results suggest that constitutive and ubiquitous overexpression of CuZnSOD alone is not sufficient to extend the life spans of transgenic mice.
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“but in isolated liver mitochondria, an [O2] >50 μM does not alone result in greater O2•− generation, as shown in Fig. 20 (161).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [161]
In the citing paper
“It was of interest, however, that H2O2 generation as a percentage of the respiratory rate increased fourfold (state 4) and sixfold (state 3) from 20 μM to near zero [O2].”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [161]
In the citing paper
“However, this must be reconciled by the finding in isolated mitochondria that hypoxia does not itself increase ROS (Fig. 20) (161).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [161]
Citations
Cites
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879
Orr, W. C., & Sohal, R. S. (1994) · Science · doi:10.1126/science.8108730 · Cited by 1,461
Aging and resistance to oxidative damage in Caenorhabditis elegans.
Larsen, P. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8905 · Cited by 722
Forster, M. J., Dubey, A., Dawson, K. M., Stutts, W. A., Lal, H., & Sohal, R. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4765 · Cited by 494
Crow, J. P., Sampson, J. B., Zhuang, Y., Thompson, J. A., & Beckman, J. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69051936.x · Cited by 487
Sun, J., & Tower, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.216 · Cited by 467
Epstein, C. J., Avraham, K. B., Lovett, M., Smith, S. H., Elroy‐Stein, O., Rotman, G., Bry, C., & Groner, Y. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.8044 · Cited by 454
Self-citationCrow, J. P., Ye, Y. Z., Strong, M. J., KIRK, M. C., Barnes, S., & Beckman, J. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69051945.x · Cited by 260
Reactive oxygen species and Alzheimer's disease
Multhaup, G., Ruppert, T., Schlicksupp, A., Hesse, L., Beher, D., Masters, C. L., & Beyreuther, K. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00062-2 · Cited by 228
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Page, M. M. (2011) · Brock University Digital Repository (Brock University)
Correlation of Protein Homeostasis With Maximum Lifespans in Endothermic Vertebrates
Salway, K. D. (2013) · Brock University Digital Repository (Brock University)
Kregel, K. C., & Zhang, H. J. (2012)
de Agricultura, E. S., & de Queiroz, L. (2010)
Loniewska, M. M. (2013) · TSpace (University of Toronto)
Exploring the Mechanism of Aging Using Rodent Models
Ikeno, Y., & Remmen, H. V. (2003) · Springer eBooks · doi:10.1007/978-94-017-0671-1_9
Philosophical problems of modern anthropogenetic researches
Nikolayenko, N. (2015)
Köester, V. (2018) · ChemViews · doi:10.1002/chemv.201800061
Genetics of Life Span: Lessons from Model Organisms
Marı́n-Garcı́a, J., Goldenthal, M. J., & Moe, G. W. P. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74072-0_12
Oxidative Stress in Metabolic Disorders/Diseases
Bansal, M., & Kaushal, N. (2014) · Springer eBooks · doi:10.1007/978-81-322-2032-9_3 · Cited by 1
Anti-Aging Medicine LiteratureWatch
(2000) · Rejuvenation Research · doi:10.1089/10945450050164808
Anti-Aging Medicine LiteratureWatch
Pawelec, G. (2000) · Rejuvenation Research · doi:10.1089/rej.1.2000.3.207
Multi-omic analysis of the aging mouse brain
Kluever, V. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9022
Austad, S. N. (2006) · Gender Medicine · doi:10.1016/s1550-8579(06)80222-6
Al-Regaiey, K. (2013) · Atlas Journal of Biology · doi:10.5147/ajb.2013.0086
Establishing a role for specific nutrients in Drosophila dietary restriction
Grandison, R. C. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Metadata
- Authors
- Huang, T., Carlson, E. J., Gillespie, A. M., Shi, Y., & Epstein, C. J.
- Affiliations
- University of California, San Francisco (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 55
- Issue
- 1
- Pages
- B5-B9
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2134200048
- Cited by
- 216
- References
- 34
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 11 · 2013: 10 · 2012: 12
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG16998, R01AG016998, AG-08938, P01AG008938)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- Cu/Zn superoxide dismutase, lifespan extension, aging, oxidative stress, superoxide, transgenic mice, ICR mice, antioxidant enzymes, degenerative diseases
- MeSH terms
- Aging, Analysis of Variance, Animals, Longevity, Mice, Transgenic, Superoxide Dismutase, Chi-Square Distribution, Proportional Hazards Models, Free Radical Scavengers, Mice
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