Cited by 216Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceRedox biology and oxidative stress

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Ubiquitous overexpression of CuZn superoxide dismutase does not extendlife span in mice

Ting‐Ting Huang, Elaine J. Carlson, A M Gillespie, Y Shi, Charles J. Epstein·2000·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/55.1.b5

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Abstract

Oxidative damage has been implicated in the aging process and in a number of degenerative diseases. To investigate the role of oxygen radicals in the aging process in mammals, the life spans of transgenic mice on a CD-1 background expressing increased levels of CuZn superoxide dismutase (CuZnSOD), the enzyme that metabolizes superoxide radicals, were determined. Homozygous transgenic mice with a two- to five-fold elevation of CuZnSOD in various tissues showed a slight reduction of life span, whereas hemizygous mice with a 15- to 3-fold increase of CuZnSOD showed no difference in life span from that of the nontransgenic littermate controls. The results suggest that constitutive and ubiquitous overexpression of CuZnSOD alone is not sufficient to extend the life spans of transgenic mice.

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Authors: Huang, T., Carlson, E. J., Gillespie, A. M., Shi, Y., & Epstein, C. J.
Affiliations: University of California, San Francisco (US)
ORCID: Ting‐Ting Huang
Charles J. Epstein
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 2000-01-01
Volume: 55
Issue: 1
Pages: B5-B9
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/55.1.b5
OpenAlex: W2134200048
Cited by: 216
References: 34
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 11 · 2013: 10 · 2012: 12
FWCI: 3.32
Type: journal article
Language: en
Open access: closed
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG16998, R01AG016998, AG-08938, P01AG008938)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: Cu/Zn superoxide dismutase, lifespan extension, aging, oxidative stress, superoxide, transgenic mice, ICR mice, antioxidant enzymes, degenerative diseases
MeSH terms: Aging, Analysis of Variance, Animals, Longevity, Mice, Transgenic, Superoxide Dismutase, Chi-Square Distribution, Proportional Hazards Models, Free Radical Scavengers, Mice

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Ubiquitous overexpression of CuZn superoxide dismutase does not extendlife span in mice

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