The overexpression of major antioxidant enzymes does not extend the lifespan of mice
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We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.
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Various combinations of Sod2, cytosolic Sod1, or catalase transgenes also fail to extend the lifespan of mice.
“Various combinations of Sod2, cytosolic Sod1, or catalase transgenes also fail to extend the lifespan of mice 92.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [92]
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- Authors
- Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- Albert Einstein College of Medicine (US)
- South Texas Veterans Health Care System (US)
- Corresponding author
- Richardson, Arlan
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2009-01-28
- Volume
- 8
- Issue
- 1
- Pages
- 73-75
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC2667893
- OpenAlex
- W2005586848
- Cited by
- 353
- References
- 19
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 16 · 2023: 16 · 2022: 18 · 2021: 13 · 2020: 13 · 2019: 18 · 2018: 21 · 2017: 20 · 2016: 20 · 2015: 14 · 2014: 27 · 2013: 25 · 2012: 31
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Aging Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (1P30- AG13319, P01 AG19316, R37AG026557, P01AG019316, P30AG013319)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- antioxidant enzymes, lifespan extension, superoxide dismutase, catalase, manganese superoxide dismutase, copper-zinc superoxide dismutase, transgenic mice, oxidative stress, aging, mitochondrial superoxide
- MeSH terms
- Animals, Catalase, Disease Models, Animal, Humans, Hydrogen Peroxide, Longevity, Mice, Inbred C57BL, Mice, Transgenic, Superoxide Dismutase, Oxidative Stress, Reverse Transcriptase Polymerase Chain Reaction, Mice
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