Cited by 353Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceRedox biology and oxidative stress

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

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Pérez, Viviana I., Van Remmen, Holly, Bokov, Alex, Epstein, Charles J., Vijg, Jan, Richardson, Arlan·2009·Aging Cell

Abstract

We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.

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Crossref · 10.1111/j.1474-9726.2008.00449.x

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Authors
Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A.
Affiliations
  • The University of Texas at San Antonio Health Science Center (US)
  • University of California, San Francisco (US)
  • Albert Einstein College of Medicine (US)
  • South Texas Veterans Health Care System (US)
Corresponding author
Richardson, Arlan
Venue
Aging Cell
Publisher
Wiley
Published
2009-01-28
Volume
8
Issue
1
Pages
73-75
ISSN
  • 1474-9718 (ISSN-L)
  • 1474-9726
OpenAlex
W2005586848
Cited by
353
References
19
Citations by year
2026: 5 · 2025: 9 · 2024: 16 · 2023: 16 · 2022: 18 · 2021: 13 · 2020: 13 · 2019: 18 · 2018: 21 · 2017: 20 · 2016: 20 · 2015: 14 · 2014: 27 · 2013: 25 · 2012: 31
FWCI
8.45
Type
journal article
Language
en
Open access
Locations
  • Aging Cell (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (1P30- AG13319, P01 AG19316, R37AG026557, P01AG019316, P30AG013319)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
antioxidant enzymes, lifespan extension, superoxide dismutase, catalase, manganese superoxide dismutase, copper-zinc superoxide dismutase, transgenic mice, oxidative stress, aging, mitochondrial superoxide
MeSH terms
Animals, Catalase, Disease Models, Animal, Humans, Hydrogen Peroxide, Longevity, Mice, Inbred C57BL, Mice, Transgenic, Superoxide Dismutase, Oxidative Stress, Reverse Transcriptase Polymerase Chain Reaction, Mice

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