The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Age-Related Differences in Hippocampal Extracellular Fluid Glucose Concentration During Behavioral Testing and Following Systemic Glucose Administration
Abstract
Recent evidence indicates that the level of glucose in the brain's extracellular fluid (ECF) is not constant, as traditionally thought, but fluctuates. We determined the effect of aging on hippocampal ECF glucose before, during, and after spatial memory testing. Fischer-344 rats (24 months old) showed a greater decrease in ECF glucose than 3-month-old rats (48% vs 12%); the decrease seen in 24-month-old rats persisted for much longer following testing. These changes were associated with an age-related deficit in spontaneous alternation performance. Following systemic glucose administration, the decrease in ECF glucose was reversed in both aged and young rats, and performance in aged versus young rats following glucose administration did not differ. These findings suggest that increased susceptibility to depletion of ECF glucose in aged rats may contribute to age-related deficits in learning and memory and that administration of glucose may enhance memory by providing additional glucose to the brain at times of increased cognitive demand.
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“The drop in hippocampal glucose levels is deeper and lasts longer among older animals, perhaps indicating why older animals have impairments in memory performance (33).”
From Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly (2003) · cites this paper as [33]
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Metadata
- Authors
- McNay, E. C., & Gold, P. E.
- Affiliations
- Yale University (US)
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- McNay, E. C.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02-01
- Volume
- 56
- Issue
- 2
- Pages
- B66-B71
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2137593311
- Cited by
- 132
- References
- 40
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 9
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Alzheimer's Association
- Glenn Foundation for Medical Research
- Yale University
- University of Illinois at Urbana-Champaign
- Raymond and Beverly Sackler Institute for Biological, Physical and Engineering Sciences, Yale University
- National Institute on Aging (R01AG007648, AG 07648)
- National Institute of Neurological Disorders and Stroke (NS-32914, R01NS032914)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- aging, spatial memory, spontaneous alternation, glucose administration, age-related memory decline, learning and memory, F344 rats
- MeSH terms
- Aging, Animals, Behavior, Animal, Extracellular Space, Glucose, Hippocampus, Male, Memory, Osmolar Concentration, Rats, Inbred F344, Space Perception, Microdialysis, Maze Learning, Rats
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