Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task
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Using in vivo microdialysis, we measured hippocampal extracellular glucose concentrations in rats while they performed spontaneous alternation tests of spatial working memory in one of two mazes. Extracellular glucose levels in the hippocampus decreased by 32% below baseline during the test period on the more complex maze, but by a maximum of 11% on the less complex maze. Comparable decreases were not observed in samples taken from rats tested on the more complex maze but with probes located near but outside of the hippocampus. Systemic glucose fully blocked any decrease in extracellular glucose and enhanced alternation on the more complex maze. These findings suggest that cognitive activity can deplete extracellular glucose in the hippocampus and that exogenous glucose administration reverses the depletion while enhancing task performance.
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During a memory test, localized drops in hippocampal glucose levels occur that are proportional to the difficulty of the maze.
“From animal studies we know that during a memory test (e.g., going through a maze), as the hippocampus is activated, localized drops in hippocampal glucose levels occur that are proportional to the difficulty of the maze (32).”
From Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly (2003) · cites this paper as [32]
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- Authors
- McNay, E. C., Fries, T. M., & Gold, P. E.
- Affiliations
- Binghamton University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2000-03-07
- Volume
- 97
- Issue
- 6
- Pages
- 2881-2885
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC16024
- OpenAlex
- W2142240447
- Cited by
- 386
- References
- 47
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 13 · 2023: 10 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 11 · 2018: 14 · 2017: 17 · 2016: 17 · 2015: 21 · 2014: 19 · 2013: 16 · 2012: 19
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Glenn Foundation for Medical Research
- University of Virginia
- U.S. Public Health Service
- National Institute on Aging (R01AG007648, AG 07648)
- National Institute of Neurological Disorders and Stroke (NS-32914, R01NS032914)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- spatial working memory, spontaneous alternation, cognitive demand, glucose metabolism, in vivo microdialysis
- MeSH terms
- Animals, Cognition, Extracellular Space, Glucose, Hippocampus, Male, Memory, Spatial Behavior, Time Factors, Rats, Sprague-Dawley, Microdialysis, Maze Learning, Rats
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