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Cited by 62Growth Hormone and Insulin-like Growth FactorsNutrition and Health in AgingHormonal and reproductive studies

Serum insulin-like growth factor-1 in centenarians: implications of IGF-1 as a rapid turnover protein

Arai, Y., Hirose, N., Yamamura, K., Shimizu, K.-i., Takayama, M., Ebihara, Y., Osono, Y.·2001·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
DOI 10.1093/gerona/56.2.m79
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Abstract

BACKGROUND: It is well documented that serum insulin-like growth factor 1 (IGF-1) levels as well as growth hormone secretion decline with advancing age. Low levels of IGF-1 are shown to be associated with low activity of growth hormone, low lean mass, and high body fat mass; however, in the elderly, the relationship has not been confirmed. METHODS: We studied serum IGF-1 levels in 49 centenarians, who are at the ultimate stage of physiological senescence, and investigated the possible relationship between IGF-1 and body mass index, lipid parameters, nutritional indices, physical and cognitive function, and frequency of hip fracture. As nutritional indices, serum levels of albumin, prealbumin, transferrin, and retinol binding protein were measured. Cognitive function of the centenarians was assessed by clinical dementia rating. RESULTS: In the centenarians, the mean levels of IGF-1 were relatively low, indicating that there is an age-associated decline in IGF-1 even in the extremely old age. We demonstrated a strong association of IGF-1 with prealbumin and retinol binding protein (r2 = .192, .195, respectively); however, there was no association with albumin, transferrin, or body mass index. Interestingly, centenarians with lower IGF-1 levels had a higher prevalence of definitive dementia. CONCLUSIONS: These data suggest that serum IGF-1 levels in the centenarians appeared to reflect their short-term nutritional status as a rapid turnover protein. It is also suggested that low levels of serum IGF-1 may be involved in the progression of dementia in the oldest old.

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Research works printed but not linked: 2

  1. Arai Y, Hirose N, Kawamura M, et al. Lipid and lipoprotein profile of Japanese centenarians-High prevalence of hypobetalipoprotein- emia-Tokyo Centenarian Study 1. Jpn J Geriatr. 1997;34:202-208.
  2. Shimazu A, Fujieda K, Hanyu K, et al. Clinical evaluation of serum IGF-I, IGF-II and IGFBP-3 measured by IRMA kits in adulthood. J Clin Endocrinol. 1996;44:1129-1138.

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Authors
Arai, Y., Hirose, N., Yamamura, K., Shimizu, K.-I., Takayama, M., Ebihara, Y., & Osono, Y.
Affiliations
  • Keio University (JP)
  • Aoyama Gakuin University (JP)
Corresponding author
Arai, Y.
ORCID
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher
Oxford University Press (OUP)
Published
2001-02-01
Volume
56
Issue
2
Pages
M79-M82
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
DOI
10.1093/gerona/56.2.m79
OpenAlex
W2138075180
Cited by
62
References
25
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 1
FWCI
4.16
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
Funders
Keio University
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
insulin-like growth factor I, centenarians, aging, rapid turnover proteins, nutritional status, prealbumin, retinol-binding protein, albumin, transferrin, body mass index, dementia, cognitive function, hip fracture, growth hormone
MeSH terms
Aged, Aged, 80 and over, Aging, Dementia, Humans, Insulin-Like Growth Factor I, Japan, Prealbumin, Retinol-Binding Proteins, Time Factors, Prevalence

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