ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians’ Perspective
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studies from worms to mice showed that downregulated activity of the GH/IGF-1/insulin pathway could be beneficial for the extension of human life span, whereas results are contradictory in humans. In the present review, we discuss the potential role of the IGF-1 system in modulation of longevity, hypothesizing that the endocrine and metabolic adaptation observed in centenarians and in mammals during caloric restriction may be a physiological strategy for extending lifespan through a slower cell growing/metabolism, a better physiologic reserve capacity, a shift of cellular metabolism from cell proliferation to repair activities and a decrease in accumulation of senescent cells. Therefore, understanding of the link between IGF-1/insulin system and longevity may have future clinical applications in promoting healthy aging and in Rehabilitation Medicine.
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The lifespan and healthspan of invertebrates are extended by mutations in pathways such as DAF-2, a gene that encodes for the IGF-1 pathway in C. elegans, or the mTOR signaling pathways that are linked to accelerating the aging process.
“The lifespan and healthspan of invertebrates are extended by mutations in pathways such as the DAF-2, a gene that encodes for the IGF-1 pathway in the nematode Caenorhabditis elegans (C. elegans), or the mTOR signaling pathways that are linked to accelerating the aging process (60, 62–65).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [65]
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Reversal of epigenetic aging and immunosenescent trends in humans.
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Nutrition and longevity—From mechanisms to uncertainties
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The significance of caloric restriction mimetics as anti-aging drugs
Nassar, K., El-mekawey, D., Elmasry, A. E., Refaey, M. S., El-Sayed Ghoneim, M., & Elshaier, Y. A. M. M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149354 · Cited by 16 · see citing works
- Authors
- Vitale, G., Pellegrino, G., Vollery, M., & Hofland, L. J.
- Affiliations
- University of Milan (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Erasmus MC (NL)
- Corresponding author
- Vitale, Giovanni
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-02-01
- Volume
- 10
- Pages
- 27-27
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6367275
- OpenAlex
- W2912063221
- Cited by
- 166
- References
- 123
- Citations by year
- 2026: 8 · 2025: 23 · 2024: 28 · 2023: 24 · 2022: 17 · 2021: 29 · 2020: 29 · 2019: 8
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- insulin-like growth factor I, longevity, centenarians, caloric restriction, lifespan extension, healthy aging, cellular senescence, physiological reserve, cell proliferation, rehabilitation medicine
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