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The Mechanisms of Androgen Effects on Body Composition: Mesenchymal Pluripotent Cell as the Target of Androgen Action
Abstract
Testosterone supplementation increases muscle mass primarily by inducing muscle fiber hypertrophy; however, the mechanisms by which testosterone exerts its anabolic effects on the muscle are poorly understood. The prevalent view is that testosterone improves net muscle protein balance by stimulating muscle protein synthesis, decreasing muscle protein degradation, and improving the reutilization of amino acids. However, the muscle protein synthesis hypothesis does not adequately explain testosterone-induced changes in fat mass, myonuclear number, and satellite cell number. We postulate that testosterone promotes the commitment of pluripotent stem cells into the myogenic lineage and inhibits their differentiation into the adipogenic lineage. The hypothesis that the primary site of androgen action is the pluripotent stem cell provides a unifying explanation for the observed reciprocal effects of testosterone on muscle and fat mass.
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“Data obtained from in vitro experiments show that testosterone and DHT can inhibit the differentiation of human and BM‐mesenchymal pluripotent cells into adipocytes via AR dependent pathway. 110 , 111 , 112 , 113”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [112]
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Metadata
- Authors
- Bhasin, S., Taylor, W. E., Singh, R., Artaza, J., Sinha-Hikim, I., Jasuja, R., Choi, H., & Gonzalez-Cadavid, N. F.
- Affiliations
- Charles R. Drew University of Medicine and Science (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-01
- Volume
- 58
- Issue
- 12
- Pages
- M1103-M1110
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2119860085
- Cited by
- 215
- References
- 63
- Citations by year
- 2025: 11 · 2024: 7 · 2023: 2 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 5 · 2017: 13 · 2016: 9 · 2015: 3 · 2014: 7 · 2013: 7 · 2012: 12
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- testosterone, androgens, body composition, muscle mass, fat mass, myogenic lineage, adipogenesis, muscle protein synthesis, muscle protein degradation, satellite cells, myonuclear number, muscle fiber hypertrophy, anabolic effects
- MeSH terms
- Adolescent, Adult, Biopsy, Needle, Body Composition, Child, Child, Preschool, Humans, Immunohistochemistry, Male, Muscle Proteins, Sensitivity and Specificity, Stem Cells, Testosterone, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development, Pluripotent Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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