The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Cerebral White Matter Changes and Geriatric Syndromes: Is There a Link?
Abstract
Cerebral white matter lesions (WMLs), also called "leukoaraiosis," are common neuroradiological findings in elderly people. WMLs are often located at periventricular and subcortical areas and manifest as hyperintensities in magnetic resonance imaging. Recent studies suggest that cardiovascular risk factors are associated with the development of WMLs. These lesions are associated with different geriatric syndromes such as falls, executive cognitive impairment, depressive symptoms, and urinary incontinence. Damage to associative pathways in frontal and subcortical regions due to hypoperfusion may disrupt frontal executive, motor control, and other systems, resulting in these manifestations. WMLs are associated with substantial disability and should not be considered a benign and silent condition as once believed. Interventions addressing cardiovascular risk factors should be undertaken in early or mid-life in order to prevent late-life functional impairment associated with WMLs. After these lesions develop and impair executive cognitive functions, the patient's ability to comply with a complex risk reduction program may be significantly compromised.
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Cerebral Perfusion and Cerebrovascular Reactivity Are Reduced in White Matter Hyperintensities
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Cited by
Peters, R. (2006) · Postgraduate Medical Journal · doi:10.1136/pgmj.2005.036665 · Cited by 894
Inzitari, D., Pracucci, G., Poggesi, A., Carlucci, G., Barkhof, F., Chabriat, H., Erkinjuntti, T., Fazekas, F., Ferro, J. M., Hennerici, M., et al. (2009) · BMJ · doi:10.1136/bmj.b2477 · Cited by 415
Executive Function, Memory, and Gait Speed Decline in Well-Functioning Older Adults
Watson, N. L., Rosano, C., Boudreau, R. M., Simonsick, E. M., Ferrucci, L., Sutton-Tyrrell, K., Hardy, S. E., Atkinson, H. H., Yaffe, K., Satterfield, S., et al. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq111 · Cited by 286
Psychiatric Disease in the Twenty-First Century: The Case for Subcortical Ischemic Depression
Taylor, W. D., Steffens, D. C., & Krishnan, K. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.028 · Cited by 56
Metadata
- Authors
- Kuo, H.-K., & Lipsitz, L. A.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-08-01
- Volume
- 59
- Issue
- 8
- Pages
- M818-M826
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2159391588
- Cited by
- 176
- References
- 11
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
