The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway
Open accessAbstract
The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his article "IL-6: A Cytokine for Gerontologists," indicated IL-6 as one of the main signaling pathways modulating the complex relationship between aging and chronic morbidity. Over the last 12 years, our understanding of the role of IL-6 in human physiology and pathology has substantially grown, although some of the questions originally posed by Ershler are still debated. In this review, we will focus on IL-6 structure, IL-6 signaling, and trans signaling pathways, and the role of IL-6 in geriatric syndromes and chronic disease. In the final section of this review, we dissect the critical elements of the IL-6 signaling pathway and point out targets for intervention that are targeted by emerging drugs, some still on the horizon and others already being tested in clinical trials.
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Cites
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“It has been suggested that IL-6 is important for the process of muscle repair and cell turnover, as well as for some of the beneficial health effects of exercise, especially on lipids (63).”
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Cited by
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891
Inflammatory networks during cellular senescence: causes and consequences.
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Aging in COVID-19: Vulnerability, immunity and intervention
Chen, Y., Klein, S. L., Garibaldi, B. T., Li, H., Wu, C., Osevala, N. M., Li, T., Margolick, J. B., Pawelec, G., & Leng, S. X. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101205 · Cited by 1,007
How the ageing microenvironment influences tumour progression
Fane, M., & Weeraratna, A. T. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0222-9 · Cited by 849
Metadata
- Authors
- Maggio, M., Guralnik, J. M., Longo, D. L., & Ferrucci, L.
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06-01
- Volume
- 61
- Issue
- 6
- Pages
- 575-584
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2098930053
- Cited by
- 692
- References
- 28
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Maggio, M., Guralnik, J. M., Longo, D. L., & Ferrucci, L. (2006). Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway. The Journals of Gerontology: Series A. https://doi.org/10.1093/gerona/61.6.575
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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