Cited by 388COVID-19 Clinical Research StudiesGenetic Associations and EpidemiologySARS-CoV-2 and COVID-19 Research

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APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

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Kuo, Chia-Ling, Pilling, Luke C, Atkins, Janice L, Masoli, Jane A H, Delgado, João, Kuchel, George A, Melzer, David·2020·The Journals of Gerontology: Series A

DOI 10.1093/gerona/glaa131PMC PMC7314139

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Abstract

The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common. In older adults, we found that pre-existing dementia is a major risk factor (OR = 3.07, 95% CI: 1.71 to 5.50) for COVID-19 hospitalization in the UK Biobank (UKB). In another UK study of 16,749 patients hospitalized for COVID-19, dementia was among the common comorbidities and was associated with higher mortality. Additionally, impaired consciousness, including delirium, is common in severe cases. The ApoE e4 genotype is associated with both dementia and delirium, with the e4e4 (homozygous) genotype associated with high risk of dementia. We therefore aimed to test associations between ApoE e4 alleles and COVID-19 severity, using the UKB data.

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Authors: Kuo, C.-L., Pilling, L. C., Atkins, J. L., Masoli, J. A. H., Delgado, J., Kuchel, G. A., & Melzer, D.
Affiliations: UConn Health (US)
University of Exeter (GB)
Corresponding author: Melzer, David
ORCID: Kuo, Chia-Ling
Pilling, Luke C
Atkins, Janice L
Masoli, Jane A H
Delgado, João
Kuchel, George A
Melzer, David
Venue: The Journals of Gerontology: Series A
Publisher: Oxford University Press (OUP)
Published: 2020-05-26
Volume: 75
Issue: 11
Pages: 2231-2232
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/glaa131
PMC: PMC7314139
OpenAlex: W3031869734
Cited by: 388
References: 13
Citations by year: 2026: 8 · 2025: 15 · 2024: 32 · 2023: 59 · 2022: 88 · 2021: 117 · 2020: 69
FWCI: 10.92
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: The Journals of Gerontology Series A (publishedVersion, cc-by)
medRxiv (acceptedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Royal Devon and Exeter Research Repository (Royal Devon and Exeter) (submittedVersion, cc-by)
Funders: National Institutes of Health
National Institute on Aging (R21AG060018)
UK Medical Research Council (MR/S009892/1)
National Institute for Health Research (DRF-2014-07-177)
Department of Health
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords: APOE ε4, COVID-19 severity, Alzheimer's disease risk, dementia, delirium, rs429358, rs7412, genetic susceptibility, older adults, UK Biobank, community-based cohort, SARS-CoV-2, European ancestry, comorbidities, mortality risk, hospitalization risk
MeSH terms: Betacoronavirus, COVID-19, SARS-CoV-2, Aged, England, Female, Homozygote, Humans, Male, Pneumonia, Viral, Severity of Illness Index, Survival Analysis, Biological Specimen Banks, Coronavirus Infections, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Apolipoprotein E4, Pandemics

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APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

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