Melzer, David

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 4,531

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 2,166

Systematic identification of trans eQTLs as putative drivers of known disease associations

Westra, H.-J., Peters, M. J., Esko, T., Yaghootkar, H., Schurmann, C., Kettunen, J., Christiansen, M. W., Fairfax, B. P., Schramm, K., Powell, J. E., et al. (2013) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 1,658

DNA methylation-based measures of biological age: meta-analysis predicting time to death

Chen, B. H., Marioni, R. E., Colicino, E., Peters, M. J., Ward-Caviness, C. K., Tsai, P.-C., Roetker, N. S., Just, A. C., Demerath, E. W., Guan, W., et al. (2016) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 1,126

The transcriptional landscape of age in human peripheral blood

Peters, M. J., Joehanes, R., Pilling, L. C., Schurmann, C., Conneely, K. N., Powell, J., Reinmaa, E., Sutphin, G. L., Zhernakova, A., Schramm, K., et al. (2015) · Nature Communications

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 725

Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06

Melzer, D., Rice, N. E., Lewis, C., Henley, W. E., & Galloway, T. S. (2010) · PLoS ONE

Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants Impact

Cited by 572

Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey

Melzer, D., Rice, N., Depledge, M. H., Henley, W. E., & Galloway, T. S. (2010) · Environmental Health Perspectives

Per- and polyfluoroalkyl substances researchChemical Analysis and Environmental Impact

Cited by 496

A genome-wide association study identifies protein quantitative trait loci (pQTLs)

Melzer, D., Perry, J. R. B., Hernandez, D., Corsi, A.-M., Stevens, K., Rafferty, I., Lauretani, F., Murray, A., Gibbs, J. R., Paolisso, G., et al. (2008) · PLoS Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 480

APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

Kuo, C.-L., Pilling, L. C., Atkins, J. L., Masoli, J. A. H., Delgado, J., Kuchel, G. A., & Melzer, D. (2020) · The Journals of Gerontology: Series A

COVID-19 Clinical Research StudiesGenetic Associations and Epidemiology

Cited by 388

Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001–2010

Tyrrell, J., Melzer, D., Henley, W., Galloway, T. S., & Osborne, N. J. (2013) · Environment International

Heavy Metal Exposure and ToxicityEffects and risks of endocrine disrupting chemicals

Cited by 226

Genetic determinants of serum testosterone concentrations in men

Ohlsson, C., Wallaschofski, H., Lunetta, K. L., Stolk, L., Perry, J. R. B., Koster, A., Petersen, A.-K., Eriksson, J., Lehtimäki, T., Huhtaniemi, I. T., et al. (2011) · PLoS Genetics

Hormonal and reproductive studiesGenetic Associations and Epidemiology

Cited by 224

Human longevity: 25 genetic loci associated in 389,166 UK biobank participants

Pilling, L. C., Kuo, C.-L., Sicinski, K., Tamosauskaite, J., Kuchel, G. A., Harries, L. W., Herd, P., Wallace, R., Ferrucci, L., & Melzer, D. (2017) · Aging

Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 211

Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank

Pilling, L. C., Tamosauskaite, J., Jones, G., Wood, A. R., Jones, L., Kuo, C.-L., Kuchel, G. A., Ferrucci, L., & Melzer, D. (2019) · BMJ

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 198

A Genome-Wide Association Study of Depressive Symptoms

Hek, K., Demirkan, A., Lahti, J., Terracciano, A., Teumer, A., Cornelis, M. C., Amin, N., Bakshis, E., Baumert, J., Ding, J., et al. (2013) · Biological Psychiatry

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Cited by 172

A Common Variation in Deiodinase 1 Gene DIO1 Is Associated with the Relative Levels of Free Thyroxine and Triiodothyronine

Panicker, V., Cluett, C., Shields, B., Murray, A., Parnell, K. S., Perry, J. R. B., Weedon, M. N., Singleton, A., Hernandez, D., Evans, J., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsGenetic Associations and Epidemiology

Cited by 155

Trends in service use and treatment for mental disorders in adults throughout Great Britain

Brugha, T. S., Bebbington, P. E., Singleton, N., Melzer, D., Jenkins, R., Lewis, G., Farrell, M., Bhugra, D., Lee, A., & Meltzer, H. (2004) · British Journal of Psychiatry

Mental Health Treatment and AccessPsychiatric care and mental health services

Cited by 114

Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants

Bowman, K., Atkins, J. L., Delgado, J., Kos, K., Kuchel, G. A., Ble, A., Ferrucci, L., & Melzer, D. (2017) · The American Journal of Clinical Nutrition

Obesity, Physical Activity, DietDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 100

Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels

Rafiq, S., Stevens, K., Hurst, A. J., Murray, A., Henley, W., Weedon, M. N., Bandinelli, S., Corsi, A. M., Guralnik, J. M., Ferruci, L., et al. (2007) · Genes & Immunity

Genetic Associations and EpidemiologyAdipokines, Inflammation, and Metabolic Diseases

Cited by 92

A common variant of the p16INK4a genetic region is associated with physical function in older people

Melzer, D., Frayling, T. M., Murray, A., Hurst, A. J., Harries, L. W., Song, H., Khaw, K., Luben, R., Surtees, P. G., Bandinelli, S. S., et al. (2007) · Mechanisms of Ageing and Development

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 84

ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants

Kuo, C.-L., Pilling, L. C., Atkins, J. L., Kuchel, G. A., & Melzer, D. (2020) · Aging

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 55

Mid‐life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants

Liu, R., Xiang, M., Pilling, L. C., Melzer, D., Wang, L., Manning, K. J., Steffens, D. C., Bowden, J., Fortinsky, R. H., Kuchel, G. A., et al. (2023) · Aging Cell

Dementia and Cognitive Impairment ResearchTelomeres, Telomerase, and Senescence

Cited by 33

Gene expression markers of age-related inflammation in two human cohorts

Pilling, L. C., Joehanes, R., Melzer, D., Harries, L. W., Henley, W., Dupuis, J., Lin, H., Mitchell, M., Hernandez, D., Ying, S.-X., et al. (2015) · Experimental Gerontology

Genetics, Aging, and Longevity in Model OrganismsCytokine Signaling Pathways and Interactions

Cited by 24

Genetic Polymorphisms and Human Aging: Association Studies Deliver

Melzer, D. (2008) · Rejuvenation Research

Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 15

Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people

Cluett, C., Brayne, C., Clarke, R., Evans, G., Matthews, F., Rubinsztein, D. C., Huppert, F., Llewellyn, D. J., Rice, N., Henley, W., et al. (2010) · Neurobiology of Aging

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 12