Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884 · see citing works

Clinical characteristics of coronavirus disease 2019 in China

Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246 · see citing works

Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia

Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001316 · Cited by 16,575 · see citing works

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897 · see citing works

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

Hamming, I., Timens, W., Bulthuis, M., Lely, A., Navis, G., & van Goor, H. (2004) · The Journal of Pathology · doi:10.1002/path.1570 · Cited by 5,676 · see citing works

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

Xu, X., Chen, P., Wang, J., Feng, J., Zhou, H., Li, X., Zhong, W., & Hao, P. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1637-5 · Cited by 2,202 · see citing works

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C.-I., Ren, Z., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201712-2410oc · Cited by 1,203 · see citing works

Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes

Yang, J., Lin, S.-S., Ji, X.-J., & Guo, L.-M. (2009) · Acta Diabetologica · doi:10.1007/s00592-009-0109-4 · Cited by 1,084 · see citing works

Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion ConformationPreprint

Wrapp, D., Wang, N., Corbett, K. S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.11.944462 · Cited by 1,010 · see citing works

Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin

Zhou, P., Yang, X., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2951-z · Cited by 715 · see citing works

Expression of elevated levels of pro‐inflammatory cytokines in SARS‐CoV‐infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS

He, L., Ding, Y., Zhang, Q., Che, X., He, Y., Shen, H., Wang, H., Li, Z., Zhao, L., Geng, J., et al. (2006) · The Journal of Pathology · doi:10.1002/path.2067 · Cited by 365 · see citing works

Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

Wu, K., Li, W., Peng, G., & Li, F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908837106 · Cited by 355 · see citing works

Author Correction: A new coronavirus associated with human respiratory disease in China

Wu, F., Su, Z., Yu, B., Chen, Y., Wang, W., Song, Z., Hu, Y., Tao, Z., Tian, J.-H., Pei, Y.-Y., et al. (2020) · Nature · doi:10.1038/s41586-020-2202-3 · Cited by 318 · see citing works

Lipid rafts are involved in SARS-CoV entry into Vero E6 cells

Lu, Y., Liu, D. X., & Tam, J. P. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.023 · Cited by 269 · see citing works

ESCRT-III protein requirements for HIV-1 budding

Morita, E., Sandrin, V., McCullough, J., Katsuyama, A., Baci Hamilton, I., & Sundquist, W. I. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.02.004 · Cited by 242 · see citing works

AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension

Zhang, J., Dong, J., Martin, M., He, M., Gongol, B., Marin, T., Chen, L., Shi, X., Yin, Y., Shang, F., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201712-2570oc · Cited by 188 · see citing works

The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2

Li, W., Sui, J., Huang, I., Kuhn, J. H., Radoshitzky, S. R., Marasco, W. A., Choe, H., & Farzan, M. (2007) · Virology · doi:10.1016/j.virol.2007.04.035 · Cited by 184 · see citing works

Integrin regulation of caveolin function

Salanueva, Í. J., Cerezo, A., Guadamillas, M. C., & del Pozo, M. Á. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00109.x · Cited by 85 · see citing works

The Mechanism of Budding of Retroviruses from Cell Membranes

Pincetic, A., & Leis, J. P. (2009) · Advances in Virology · doi:10.1155/2009/623969 · Cited by 69 · see citing works

Cigarette Smoke Increases Uptake of Influenza A Virus by Lung Epithelial Cells by Increasing Expression of Caveolin-1

Embong, A. K., Duffney, P. F., Thatcher, T. H., & Sime, P. (2019) · doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4051 · Cited by 2 · see citing works

Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China

Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1127 · Cited by 7,166 · see citing works

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Yan, R., Zhang, Y., Li, Y., Xia, L., Guo, Y., & Zhou, Q. (2020) · Science · doi:10.1126/science.abb2762 · Cited by 4,950 · see citing works

The trinity of COVID-19: immunity, inflammation and intervention

Tay, M. Z., Poh, C. M., Rénia, L., MacAry, P. A., & Ng, L. F. P. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0311-8 · Cited by 4,360 · see citing works

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

Xu, H., Zhong, L., Deng, J., Peng, J., Dan, H., Zeng, X., Li, T., & Chen, Q. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0074-x · Cited by 2,838 · see citing works

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up

Bikdeli, B., Madhavan, M. V., Jiménez, D., Chuich, T., Dreyfus, I., Driggin, E., Der-Nigoghossian, C. A., Ageno, W., Madjid, M., Guo, Y., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.04.031 · Cited by 2,902 · see citing works

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

Zhang, H., Penninger, J. M., Li, Y., Zhong, N., & Slutsky, A. S. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05985-9 · Cited by 2,684 · see citing works

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

HCA Lung Biological Network, Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0868-6 · Cited by 2,501 · see citing works

Transmission routes of 2019-nCoV and controls in dental practice

Peng, X., Xu, X., Li, Y., Cheng, L., Zhou, X., & Ren, B. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0075-9 · Cited by 2,436 · see citing works

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

Monteil, V., Kwon, H., Prado, P., Hagelkrüys, A., Wimmer, R. A., Stahl, M., Leopoldi, A., Garreta, E., Hurtado del Pozo, C., Prosper, F., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.004 · Cited by 2,122 · see citing works

Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission

Peckham, H., de Gruijter, N. M., Raine, C., Radziszewska, A., Ciurtin, C., Wedderburn, L. R., Rosser, E. C., Webb, K., & Deakin, C. T. (2020) · Nature Communications · doi:10.1038/s41467-020-19741-6 · Cited by 1,503 · see citing works

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

Li, M., Li, L., Zhang, Y., & Wang, X. (2020) · Infectious Diseases of Poverty · doi:10.1186/s40249-020-00662-x · Cited by 1,605 · see citing works

SARS-CoV-2 productively infects human gut enterocytes

Lamers, M. M., Beumer, J., van der Vaart, J., Knoops, K., Puschhof, J., Breugem, T. I., Ravelli, R. B. G., Paul van Schayck, J., Mykytyn, A. Z., Duimel, H. Q., et al. (2020) · Science · doi:10.1126/science.abc1669 · Cited by 1,573 · see citing works

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

Richardson, P., Griffin, I., Tucker, C., Smith, D., Oechsle, O., Phelan, A., Rawling, M., Savory, E., & Stebbing, J. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30304-4 · Cited by 1,456 · see citing works

Coronavirus disease 2019 (COVID-19) pandemic and pregnancy

Dashraath, P., Wong, J. L. J., Lim, M. X. K., Lim, L. M., Li, S. W. L., Biswas, A., Choolani, M. A., Mattar, C. N. Z., & Su, L. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.03.021 · Cited by 1,459 · see citing works

Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia

Zhu, H., Wang, L., Fang, C., Peng, S., Zhang, L., Gui-ping, C., Xia, S., & Zhou, W. (2020) · Translational Pediatrics · doi:10.21037/tp.2020.02.06 · Cited by 1,430 · see citing works

COVID-19 and cardiovascular disease

Clerkin, K. J., Fried, J. A., Raikhelkar, J., Sayer, G., Griffin, J. M., Masoumi, A., Jain, S. S., Burkhoff, D., Kumaraiah, D., Rabbani, L., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.046941 · Cited by 1,738 · see citing works

COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

Nishiga, M., Wang, D. W., Han, Y., Lewis, D. B., & Wu, J. C. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0413-9 · Cited by 1,400 · see citing works

Impact of sex and gender on COVID-19 outcomes in Europe

Gebhard, C., Regitz‐Zagrosek, V., Neuhauser, H. K., Morgan, R., & Klein, S. L. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00304-9 · Cited by 1,306 · see citing works

Seasonality of Respiratory Viral Infections

Moriyama, M., Hugentobler, W., & Iwasaki, A. (2020) · Annual Review of Virology · doi:10.1146/annurev-virology-012420-022445 · Cited by 1,281 · see citing works

SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways.Preprint

Sungnak, W., Huang, N., Bécavin, C., & Berg, M. (2020) · PubMed · Cited by 1,196 · see citing works

SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells

Lukassen, S., Chua, R. L., Trefzer, T. B., Kahn, N. C., Schneider, M. A., Muley, T., Winter, H., Meister, M. A., Veith, C., Boots, A. W., et al. (2020) · The EMBO Journal · doi:10.15252/embj.20105114 · Cited by 1,082 · see citing works

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

Devaux, C. A., Rolain, J., Colson, P., & Raoult, D. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.105938 · Cited by 1,099 · see citing works

Angiotensin‐converting enzyme 2 ( ACE2 ), SARS‐CoV ‐2 and the pathophysiology of coronavirus disease 2019 ( COVID ‐19)

Bourgonje, A. R., Abdulle, A. E., Timens, W., Hillebrands, J., Navis, G. J., Gordijn, S. J., Bolling, M. C., Dijkstra, G. D. H., Voors, A. A., Osterhaus, A. D. M. E., et al. (2020) · The Journal of Pathology · doi:10.1002/path.5471 · Cited by 1,119 · see citing works

The protein expression profile of ACE2 in human tissues

Hikmet, F., Méar, L., Edvinsson, Å., Micke, P., Uhlén, M., & Lindskog, C. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209610 · Cited by 1,016 · see citing works

Machine learning using intrinsic genomic signatures for rapid classification of novel pathogens: COVID-19 case study

Randhawa, G. S., Soltysiak, M. P. M., El Roz, H., de Souza, C. P. E., Hill, K. A., & Kari, L. (2020) · PLOS ONE · doi:10.1371/journal.pone.0232391 · Cited by 1,023 · see citing works

COVID-19 and Multiorgan Response

Zaim, S., Chong, J. H., Sankaranarayanan, V., & Harky, A. (2020) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2020.100618 · Cited by 1,032 · see citing works

Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection

Chai, X., Hu, L., Zhang, Y., Han, W., Lu, Z., Ke, A., Zhou, J., Shi, G., Fang, N., Fan, J., et al. (2020) · doi:10.1101/2020.02.03.931766 · Cited by 952 · see citing works

Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: A Retrospective Case Series StudyPreprint

Mao, L., Wang, M., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., Miao, X., Hu, Y., et al. (2020) · medRxiv · doi:10.1101/2020.02.22.20026500 · Cited by 882 · see citing works

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

Cao, Y., Li, L., Feng, Z., Wan, S., Huang, P., Sun, X., Wen, F., Huang, X., Ning, G., & Wang, W. (2020) · Cell Discovery · doi:10.1038/s41421-020-0147-1 · Cited by 865 · see citing works

Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia

McGonagle, D., O’Donnell, J. S., Sharif, Κ., Emery, P., & Bridgewood, C. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30121-1 · Cited by 826 · see citing works

Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

Fu, Y., Cheng, Y., & Wu, Y. (2020) · Virologica Sinica · doi:10.1007/s12250-020-00207-4 · Cited by 798 · see citing works

SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far

Rabi, F. A., Zoubi, M. S. A., KASASBEH, G., Salameh, D. M., & Al‐Nasser, A. D. (2020) · Pathogens · doi:10.3390/pathogens9030231 · Cited by 773 · see citing works

Understanding of COVID‐19 based on current evidence

Sun, P., Lu, X., Xu, C., Sun, W., & Pan, B. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25722 · Cited by 1,107 · see citing works

Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China

Zhang, G., Hu, C., Luo, L., Fang, F., Chen, Y., Li, J., Peng, Z., & Pan, H. (2020) · Journal of Clinical Virology · doi:10.1016/j.jcv.2020.104364 · Cited by 691 · see citing works

Clinical characteristics of 82 cases of death from COVID-19

Zhang, B., Zhou, X., Qiu, Y., Feng, F., Feng, J., Feng, J., Zhu, H., Hu, K., JiaSheng, L., Liu, Z., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235458 · Cited by 688 · see citing works

Effect of coronavirus disease 2019 (COVID‐19) on maternal, perinatal and neonatal outcome: systematic review

Juan, J., Gil, M. M., Rong, Z., Zhang, Y., Yang, H., & Poon, L. C. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.22088 · Cited by 646 · see citing works

COVID-19: A promising cure for the global panic

Vellingiri, B., Jayaramayya, K., Iyer, M., Narayanasamy, A., Govindasamy, V., Giridharan, B., Ganesan, S., Venugopal, A., Venkatesan, D., Ganesan, H., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138277 · Cited by 637 · see citing works

2019 Novel coronavirus: where we are and what we know

Cheng, Z. J., & Shan, J. (2020) · Infection · doi:10.1007/s15010-020-01401-y · Cited by 634 · see citing works

Sex difference and smoking predisposition in patients with COVID-19

Cai, H. “. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30117-x · Cited by 627 · see citing works

scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells

Wang, Z., & Xu, X. (2020) · Cells · doi:10.3390/cells9040920 · Cited by 617 · see citing works

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

Catanzaro, M., Fagiani, F., Racchi, M., Corsini, E., Govoni, S. M., & Lanni, C. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0191-1 · Cited by 604 · see citing works

Clinical characteristics and outcomes of patients with severe COVID-19 with diabetes

Yan, Y., Yang, Y., Wang, F., Ren, H., Zhang, S., Shi, X., Yu, X., & Dong, K. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001343 · Cited by 572 · see citing works

Guillain Barre syndrome associated with COVID-19 infection: A case report

Sedaghat, Z., & Karimi, N. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2020.04.062 · Cited by 575 · see citing works

Coronavirus: Why Men are More Vulnerable to Covid-19 Than Women?

Bwire, G. M. (2020) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-020-00341-w · Cited by 584 · see citing works

Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)

Brake, S. J., Barnsley, K., Lu, W., McAlinden, K. D., Eapen, M. S., & Sohal, S. S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030841 · Cited by 537 · see citing works

Clinical characteristics of hospitalized patients with SARS‐CoV‐2 infection: A single arm meta‐analysis

Sun, P., Qie, S., Liu, Z., Ren, J., Li, K., & Xi, J. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25735 · Cited by 527 · see citing works

Face Masks in the New COVID-19 Normal: Materials, Testing, and Perspectives

Chua, M. H., Cheng, W., Goh, S. S., Kong, J., Li, B., Lim, J. Y. C., Mao, L., Wang, S., Xue, K., Yang, L., et al. (2020) · Research · doi:10.34133/2020/7286735 · Cited by 500 · see citing works

Is ethnicity linked to incidence or outcomes of covid-19?

Khunti, K. K., Singh, A. K., Pareek, M., & Hanif, W. (2020) · BMJ · doi:10.1136/bmj.m1548 · Cited by 493 · see citing works

ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

Devaux, C. A., Rolain, J., & Raoult, D. (2020) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2020.04.015 · Cited by 477 · see citing works

COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome?

Sarzi‐Puttini, P., Giorgi, V., Sirotti, S., Marotto, D., Ardizzone, S., Rizzardini, G., Antinori, S., & Galli, M. (2020) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/xcdary · Cited by 464 · see citing works

Insight into 2019 novel coronavirus — An updated interim review and lessons from SARS-CoV and MERS-CoV

Xie, M., & Chen, Q. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.03.071 · Cited by 466 · see citing works

COVID-19 infection and rheumatoid arthritis: Faraway, so close

Favalli, E. G., Ingegnoli, F., De Lucia, O., Cincinelli, G., Cimaz, R., & Caporali, R. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102523 · Cited by 454 · see citing works

Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?

BATLLE, D. C., Wysocki, J. A., & Satchell, K. J. F. (2020) · Clinical Science · doi:10.1042/cs20200163 · Cited by 444 · see citing works

The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future

Li, J.-Y., You, Z., Wang, Q., Zhou, Z., Qiu, Y., Luo, R., & Ge, X. (2020) · Microbes and Infection · doi:10.1016/j.micinf.2020.02.002 · Cited by 439 · see citing works

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

Asselta, R., Paraboschi, E. M., Mantovani, A., & Duga, S. (2020) · Aging · doi:10.18632/aging.103415 · Cited by 422 · see citing works

Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract

Smith, J. C., Sausville, E. L., Girish, V., Yuan, M. L., Vasudevan, A., John, K. M., & Sheltzer, J. M. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.05.012 · Cited by 414 · see citing works

The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study

Li, M., Chen, L., Zhang, J., Xiong, C., & Li, X. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230295 · Cited by 399 · see citing works

Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids

Zhao, B. T., Ni, C., Gao, R., Wang, Y., Li, Y., Wei, J., Lv, T., Liang, J., Zhang, Q., Xu, W., et al. (2020) · Protein & Cell · doi:10.1007/s13238-020-00718-6 · Cited by 401 · see citing works

Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China

Wang, D., Yin, Y., Hu, C., Liu, X., Zhang, X., Zhou, S., Jian, M., Xu, H., Prowle, J., Hu, B., et al. (2020) · Critical Care · doi:10.1186/s13054-020-02895-6 · Cited by 397 · see citing works

COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?

Gemmati, D., Bramanti, B., Serino, M. L., Secchiero, P., Zauli, G., & Tisato, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103474 · Cited by 401 · see citing works

Saliva: potential diagnostic value and transmission of 2019-nCoV

Xu, R., Cui, B., Duan, X., Zhang, P., Zhou, X., & Yuan, Q. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0080-z · Cited by 393 · see citing works

APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

Kuo, C.-L., Pilling, L. C., Atkins, J. L., Masoli, J. A. H., Delgado, J., Kuchel, G. A., & Melzer, D. (2020) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glaa131 · Cited by 388 · see citing works

Coronavirus disease (COVID‐19) and neonate: What neonatologist need to know

Lu, Q., & Shi, Y. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25740 · Cited by 381 · see citing works

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

Singh, K. K., Chaubey, G., Chen, J. Y., & Suravajhala, P. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00224.2020 · Cited by 382 · see citing works

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

Li, Y., Zhou, W., Li, Y., & You, R. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104833 · Cited by 378 · see citing works

Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients

Meng, Y., Wu, P., Lu, W., Liu, K., Ma, K., Huang, L., Cai, J., Zhang, H., Yu, Q., Sun, H., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008520 · Cited by 342 · see citing works

Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 Infection

Liang, Y., Wang, M., Chien, C., Yarmishyn, A. A., Yang, Y.-P., Lai, W.-Y., Luo, Y., Lin, Y.-T., Chen, Y.-J., Chang, P., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01022 · Cited by 339 · see citing works

COVID-19 Pandemic: Prevention and Protection Measures to Be Adopted at the Workplace

Cirrincione, L., Plescia, F., Ledda, C., Rapisarda, V., Martorana, D., Moldovan, R. E., Theodoridou, K., & Cannizzaro, E. (2020) · Sustainability · doi:10.3390/su12093603 · Cited by 336 · see citing works

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

Stanifer, M. L., Kee, C., Cortese, M., Metz‐Zumaran, C., Triana, S., Mukenhirn, M., Kraeusslich, H.-G., Alexandrov, T., Bartenschlager, R. F. W., & Boulant, S. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107863 · Cited by 332 · see citing works

Racial and Gender-Based Differences in COVID-19

Kopel, J. J., Perisetti, A., Roghani, A., Aziz, M., Gajendran, M., & Goyal, H. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00418 · Cited by 314 · see citing works

Oral Manifestations in Patients with COVID-19: A Living Systematic Review

dos Santos, J. A., Normando, A. G. C., da Silva, R. L. C., Acevedo, A. C., Canto, G. D. L., Sugaya, N. N., Santos‐Silva, A. R., & Guerra, E. N. S. (2020) · Journal of Dental Research · doi:10.1177/0022034520957289 · Cited by 315 · see citing works

mRNA vaccines for COVID-19: what, why and how

Park, J. W., Lagniton, P. N. P., Liu, Y., & Xu, R.-H. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59233 · Cited by 321 · see citing works

Coronavirus 2019-nCoV: A brief perspective from the front line

Han, Q., Lin, Q., Jin, S., & You, L. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.02.010 · Cited by 313 · see citing works

A Randomized Clinical Trial of the Efficacy and Safety of Interferon β-1a in Treatment of Severe COVID-19

Davoudi-Monfared, E., Rahmani, H. R., Khalili, H., Hajiabdolbaghi, M., Salehi, M., Abbasian, L., Kazemzadeh, H., & Yekaninejad, M. S. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01061-20 · Cited by 306 · see citing works

Overview of lethal human coronaviruses

Chen, B., Tian, E.-K., He, B., Tian, L., Han, R., Wang, S., Xiang, Q., Zhang, S., Arnaout, T. E., & Cheng, W. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0190-2 · Cited by 299 · see citing works

Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence

Rahman, S., Montero, M. T. V., Rowe, K., Kirton, R., & Kunik, F. (2021) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2021.1902303 · Cited by 299 · see citing works

Effect of SARS-CoV-2 infection upon male gonadal function: A single center-based studyPreprint

Ma, L., Xie, W., Li, D., Shi, L., Mao, Y., Xiong, Y., Zhang, Y., & Zhang, M. (2020) · medRxiv · doi:10.1101/2020.03.21.20037267 · Cited by 287 · see citing works

Current status of potential therapeutic candidates for the COVID-19 crisis

Zhang, J., Xie, B., & Hashimoto, K. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.046 · Cited by 282 · see citing works

Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2

Youk, J., Kim, T., Evans, K. V., Jeong, Y.-I., Hur, Y., Hong, S. P., Kim, J. H., Yi, K., Kim, S. Y., Na, K. J., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.10.004 · Cited by 266 · see citing works

The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity

Ovsyannikova, I. G., Haralambieva, I. H., Crooke, S. N., Poland, G. A., & Kennedy, R. B. (2020) · Immunological Reviews · doi:10.1111/imr.12897 · Cited by 258 · see citing works

The First 75 Days of Novel Coronavirus (SARS-CoV-2) Outbreak: Recent Advances, Prevention, and Treatment

Yan, Y., Shin, W. I., Pang, Y. X., Yang, M., Lai, J., You, C., Zhao, H., Lester, E. H., Wu, T., & Pang, C. H. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072323 · Cited by 267 · see citing works

ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population

Benetti, E., Tita, R., Spiga, O., Ciolfi, A., Birolo, G., Bruselles, A., Doddato, G., Giliberti, A., Marconi, C., Musacchia, F., et al. (2020) · European Journal of Human Genetics · doi:10.1038/s41431-020-0691-z · Cited by 259 · see citing works

Updated Approaches against SARS-CoV-2

Li, H., Zhou, Y., Zhang, M., Wang, H., Zhao, Q., & Liu, J. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00483-20 · Cited by 259 · see citing works

SARS-CoV-2 Productively Infects Human Gut EnterocytesPreprint

Lamers, M. M., Beumer, J., van der Vaart, J., Knoops, K., Puschhof, J., Breugem, T. I., Ravelli, R. B. G., van Schayck, J. P., Mykytyn, A. Z., Duimel, H., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.25.060350 · Cited by 259 · see citing works

A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors

Singh, M., Bansal, V., & Feschotte, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108175 · Cited by 239 · see citing works

Is the kidney a target of SARS-CoV-2?

Martínez-Rojas, M. A., Vega‐Vega, O., & Bobadilla, N. A. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00160.2020 · Cited by 231 · see citing works

The immunology of COVID-19: is immune modulation an option for treatment?

Zhong, J., Tang, J., Ye, C., & Dong, L. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30120-x · Cited by 236 · see citing works

Patient-derived SARS-CoV-2 mutations impact viral replication dynamics and infectivity in vitro and with clinical implications in vivo

Yao, H., Lu, X., Chen, Q., Xu, K., Chen, Y. Z., Cheng, M., Chen, K., Cheng, L., Weng, T.-H., Shi, D., et al. (2020) · Cell Discovery · doi:10.1038/s41421-020-00226-1 · Cited by 234 · see citing works

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cellsPreprint

Muus, C., Luecken, M. D., Eraslan, G., Waghray, A., Heimberg, G., Sikkema, L., Kobayashi, Y., Vaishnav, E. D., Subramanian, A., Smilie, C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.19.049254 · Cited by 245 · see citing works

Prolonged Impairment of Short-Chain Fatty Acid and L-Isoleucine Biosynthesis in Gut Microbiome in Patients With COVID-19

Zhang, F., Wan, Y., Zuo, T., Yeoh, Y. K., Liu, Q., Zhang, L., Zhan, H., Lu, W., Xu, W., Lui, G. C.-Y., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.10.013 · Cited by 230 · see citing works

COVID-19 Infection and Circulating ACE2 Levels: Protective Role in Women and Children

Ciaglia, E., Vecchione, C., & Puca, A. A. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00206 · Cited by 232 · see citing works

Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications

Iwasaki, M., Saito, J., Zhao, H., Sakamoto, A., Hirota, K., & Ma, D. (2020) · Inflammation · doi:10.1007/s10753-020-01337-3 · Cited by 229 · see citing works

Detection profile of SARS‐CoV‐2 using RT‐PCR in different types of clinical specimens: A systematic review and meta‐analysis

Bwire, G. M., Majigo, M. V., Njiro, B. J., & Mawazo, A. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26349 · Cited by 230 · see citing works

Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection

Liguori, C., Pierantozzi, M., Spanetta, M., Sarmati, L., Cesta, N., Iannetta, M., Ora, J., Mina, G. G., Puxeddu, E., Balbi, O., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.05.037 · Cited by 212 · see citing works

Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression

Schönrich, G., Raftery, M. J., & Samstag, Y. (2020) · Advances in Biological Regulation · doi:10.1016/j.jbior.2020.100741 · Cited by 221 · see citing works

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

Ou, T., Mou, H., Zhang, L., Ojha, A., Choe, H., & Farzan, M. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009212 · Cited by 208 · see citing works

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection

Synowiec, A., Szczepański, A., Barreto-Durán, E., Lie, L. K., & Pyrć, K. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00133-20 · Cited by 221 · see citing works

Neurological Manifestations of COVID-19 (SARS-CoV-2): A Review

Ahmed, M. U., Hanif, M., Ali, M. J., Haider, M. A., Kherani, D., Memon, G. M., Karim, A. H., & Sattar, A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00518 · Cited by 212 · see citing works

Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection

Bao, L., Zhang, C., Dong, J., Zhao, L., Li, Y., & Sun, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01840 · Cited by 207 · see citing works

Single-cell analysis of human lung epithelia reveals concomitant expression of the SARS-CoV-2 receptor ACE2 with multiple virus receptors and scavengers in alveolar type II cellsPreprint

Han, G., Sinjab, A. F., Treekitkarnmongkol, W., Brennan, P. M., Hara, K., Chang, K., Bogatenkova, E., Sánchez‐Espiridión, B., Behrens, C., Gao, B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.16.045617 · Cited by 6 · see citing works

Abstract 702: Single-cell expression landscape of SARS-CoV-2 receptor ACE2 and host proteases in human lung adenocarcinoma

Han, G., Sinjab, A. F., Hara, K., Treekitkarnmongkol, W., Brennan, P. M., Chang, K., Bokatenkova, E., Sánchez‐Espiridión, B., Behrens, C., Solis, L. M., et al. (2021) · Cancer Research · doi:10.1158/1538-7445.am2021-702

The protein expression profile of ACE2 in human tissues

Hikmet, F., Méar, L., Edvinsson, Å., Micke, P., Uhlén, M., & Lindskog, C. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209610 · Cited by 1,016 · see citing works

Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCoV, in the nasal tissuePreprint

Wu, C., Zheng, S., Chen, Y., & Zheng, M. (2020) · medRxiv · doi:10.1101/2020.02.11.20022228 · Cited by 85 · see citing works

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

Qi, F., Qian, S., Zhang, S., & Zhang, Z. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.044 · Cited by 905 · see citing works