Cardiovascular Health and Mitochondrial Function: Testing an Association
Open accessAbstract
Background: Although mitochondrial dysfunction appears to be a contributing factor in the pathogenesis of cardiovascular and metabolic diseases, empirical data on this association are still lacking. This study evaluated whether mitochondrial oxidative capacity, as assessed by phosphorus magnetic resonance spectroscopy, was associated with cardiovascular risk, as estimated by the Framingham Risk Score (FRS), and with a clinical history of cardiovascular disease (CVD), in community-dwelling adults. Method: A total of 616 subjects from the Baltimore Longitudinal Study of Aging (mean age 66 years) underwent a comprehensive clinical evaluation. Mitochondrial oxidative capacity in skeletal muscle was assessed as post-exercise phosphocreatine recovery time constant by phosphorus magnetic resonance spectroscopy. Multivariate regression models were employed to determine the cross-sectional association of mitochondrial oxidative capacity with FRS and history of CVD. Results: Decreased mitochondrial oxidative capacity was strongly associated with higher FRS independent of age, body composition, and physical activity. Lower oxidative capacity was also associated with a history of positive of CVD and higher number of CVD events. Conclusions: We speculate that the observed association could reflect the effect of an excessive production of oxidative species by dysfunctional mitochondria. Furthermore, decreased energy production could hamper the functionality of heart and vessels. In turn, a malfunctioning cardiovascular apparatus could fail to deliver the oxygen necessary for optimal mitochondrial energy production, therefore creating a vicious cycle. Longitudinal studies are necessary to ascertain the directionality of the association and the eventual presence of common pathogenetic roots. In conclusion, mitochondria could represent an important target for intervention in cardiovascular health.
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Impaired mitochondrial function, involving excessive ROS and reduced ATP production, is associated with visceral obesity, insulin resistance, higher circulating levels of proinflammatory markers, and loss of mobility.
“Impaired mitochondrial function, which involves excessive ROS and reduced ATP production, has been associated with visceral obesity, insulin resistance, higher circulating levels of proinflammatory markers, and loss of mobility, phenotypes that are characteristic of aging (59–64).”
From Connecting aging biology and inflammation in the omics era (2022) · cites this paper as [61]
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Cites
General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
D’Agostino, R. B., Vasan, R. S., Pencina, M. J., Wolf, P. A., Cobain, M., Massaro, J. M., & Kannel, W. B. (2008) · Circulation · doi:10.1161/circulationaha.107.699579 · Cited by 7,491 · see citing works
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432 · see citing works
Mitochondria: Dynamic Organelles in Disease, Aging, and Development
Chan, D. C. (2006) · Cell · doi:10.1016/j.cell.2006.06.010 · Cited by 1,987 · see citing works
Yakes, F. M., & Van Houten, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.514 · Cited by 1,854 · see citing works
Mechanisms by which mitochondria transport calcium
Gunter, T. E., & Pfeiffer, D. R. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.5.c755 · Cited by 1,640 · see citing works
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works
Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788 · see citing works
Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure
Lesnefsky, E. J., Moghaddas, S., Tandler, B., Kerner, J., & Hoppel, C. L. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1378 · Cited by 709 · see citing works
Role of ubiquinone in the mitochondrial generation of hydrogen peroxide
Boveris, A., Cadenas, E., & Stoppani, A. O. M. (1976) · Biochemical Journal · doi:10.1042/bj1560435 · Cited by 655 · see citing works
Mechanisms of Vascular Aging: New Perspectives
Ungvari, Z. I., Kaley, G., de Cabo, R., Sonntag, W. E., & Csiszár, A. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq113 · Cited by 534 · see citing works
The Women's Health and Aging Study: Health and Social Characteristics of Older Women with Disability
Guralnik, J. M., Fried, L. P., Simonsick, E. M., Kasper, J. D., & Lafferty, M. E. (1995) · PsycEXTRA Dataset · doi:10.1037/e306362003-001 · Cited by 504 · see citing works
Self-citationThe role of mitochondrial dysfunction in cardiovascular disease: a brief review
Chistiakov, D. A., Shkurat, T. P., Melnichenko, A. А., Grechko, A. V., & Orekhov, A. N. (2017) · Annals of Medicine · doi:10.1080/07853890.2017.1417631 · Cited by 497 · see citing works
Naressi, A., Couturier, C., Castang, I., de Beer, R., & Graveron‐Demilly, D. (2001) · Computers in Biology and Medicine · doi:10.1016/s0010-4825(01)00006-3 · Cited by 461 · see citing works
Brach, J. S., Simonsick, E. M., Kritchevsky, S., Yaffe, K., Newman, A. B., & for the Health, A. A. B. C. S. R. G. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52154.x · Cited by 453 · see citing works
Self-citationInhibition of autophagy in the heart induces age-related cardiomyopathy
Taneike, M., Yamaguchi, O., Nakai, A., Hikoso, S., Takeda, T., Mizote, I., Oka, T., Tamai, T., Oyabu, J., Murakawa, T., et al. (2010) · Autophagy · doi:10.4161/auto.6.5.11947 · Cited by 450 · see citing works
Resveratrol induces mitochondrial biogenesis in endothelial cells
Csiszár, A., Labinskyy, N., Pinto, J. T., Ballabh, P., Zhang, H., Losonczy, G., Pearson, K. J., de Cabo, R., Pacher, P., Zhang, C., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00368.2009 · Cited by 450 · see citing works
Arnold, D. L., Matthews, P. M., & Radda, G. K. (1984) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910010303 · Cited by 442 · see citing works
Mitochondria and ageing: Role in heart, skeletal muscle and adipose tissue
Boengler, K., Kosiol, M., Mayr, M., Schulz, R., & Rohrbach, S. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12178 · Cited by 421 · see citing works
Mitochondrial dysfunction in cardiovascular disease
Ballinger, S. W. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.014 · Cited by 405 · see citing works
Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
Ungvari, Z. I., Labinskyy, N., Mukhopadhyay, P., Pinto, J. T., Bagi, Z. A., Ballabh, P., Zhang, C., Pacher, P., & Csiszár, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00375.2009 · Cited by 343 · see citing works
Judge, S., Jang, Y. M., SMITH, A. R. W., Hagen, T. M., & Leeuwenburgh, C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2622fje · Cited by 328 · see citing works
Energetics of human muscle: Exercise‐induced ATP depletion
Taylor, D. J., Styles, P., Matthews, P. M., Arnold, D. L., Gadian, D. G., Bore, P. J., & Radda, G. K. (1986) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910030107 · Cited by 318 · see citing works
Tarantini, S., Valcarcel‐Ares, M. N., Tóth, P., Yabluchanskiy, A., Tucsek, Z., Kiss, T., Hertelendy, P., Kinter, M. T., Ballabh, P., Süle, Z., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101192 · Cited by 285 · see citing works
Yu, E., Calvert, P. A., Mercer, J. R., Harrison, J. B., Baker, L. L., Figg, N. L., Kumar, S., Wang, J. C., Hurst, L. A., Obaid, D. R., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.002271 · Cited by 283 · see citing works
Oxidative stress and ischemic myocardial syndromes.
Misra, M. K., Sarwat, M., Bhakuni, P., Tuteja, R., & Tuteja, N. K. (2009) · PubMed · Cited by 266 · see citing works
Csiszár, A., Labinskyy, N., Jiménez, R., Pinto, J. T., Ballabh, P., Losonczy, G., Pearson, K. J., de Cabo, R., & Ungvari, Z. I. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.004 · Cited by 248 · see citing works
Mitochondrial Dynamics in Cardiovascular Health and Disease
Ong, S., Hall, A. R., & Hausenloy, D. J. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4777 · Cited by 204 · see citing works
Ungvari, Z. I., Labinskyy, N., Gupte, S. A., Chander, P. N., Edwards, J. G., & Csiszár, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00012.2008 · Cited by 202 · see citing works
Marzetti, E., Csiszár, A., Dutta, D., Balagopal, G., Calvani, R., & Leeuwenburgh, C. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00936.2012 · Cited by 197 · see citing works
Tarantini, S., Valcarcel‐Ares, M. N., Yabluchanskiy, A., Fülöp, G. Á., Hertelendy, P., Gautam, T., Farkas, E., Perz, A., Rabinovitch, P. S., Sonntag, W. E., et al. (2018) · Aging Cell · doi:10.1111/acel.12731 · Cited by 193 · see citing works
Physical activity and the prevention of cardiovascular disease: from evolution to epidemiology.
Archer, E. C., & Blair, S. (2011) · Progress in cardiovascular diseases · doi:10.1016/j.pcad.2011.02.006 · Cited by 191 · see citing works
Linear dependence of muscle phosphocreatine kinetics on oxidative capacity
Paganini, A. T., Foley, J. M., & Meyer, R. A. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.272.2.c501 · Cited by 186 · see citing works
Is mitochondrial dysfunction a cause of insulin resistance?
Turner, N. A., & Heilbronn, L. K. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.08.001 · Cited by 163 · see citing works
Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus
Abdul-Ghani, M. A., & DeFronzo, R. A. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0030-1 · Cited by 146 · see citing works
Activities and Attitudes of Participants in the Baltimore Longitudinal Study
Stone, J. L., & Norris, A. H. (1966) · Journal of Gerontology · doi:10.1093/geronj/21.4.575 · Cited by 136 · see citing works
Kiss, T., Balasubramanian, P., Valcarcel‐Ares, M. N., Tarantini, S., Yabluchanskiy, A., Csípő, T., Lipécz, Á., Reglődi, D., Zhang, X. A., Bari, F., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00074-2 · Cited by 134 · see citing works
Liu, S. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1018650103259 · Cited by 119 · see citing works
Body composition assessment: dual-energy X-ray absorptiometry (DEXA) compared to reference methods.
Loan, M. D. V., & Mayclin, P. L. (1992) · PubMed · Cited by 116 · see citing works
Jackson, J. R., Ryan, M. J., Hao, Y., & Alway, S. E. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00489.2010 · Cited by 105 · see citing works
Time-Domain Quantification of Series of Biomedical Magnetic Resonance Spectroscopy Signals
Vanhamme, L., Huffel, S. V., Hecke, P. V., & ORMONDT, D. V. (1999) · Journal of Magnetic Resonance · doi:10.1006/jmre.1999.1835 · Cited by 102 · see citing works
Wang, D., Sun, H., Song, G., Yang, Y., Zou, X., Han, P., & Li, S. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700941 · Cited by 102 · see citing works
Kushnareva, Y. E., & Sokolove, P. M. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1730 · Cited by 98 · see citing works
Wohlgemuth, S. E., Calvani, R., & Marzetti, E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.03.007 · Cited by 97 · see citing works
Choi, S., Reiter, D. A., Shardell, M., Simonsick, E. M., Studenski, S., Spencer, R. G., Fishbein, K. W., & Ferrucci, L. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw059 · Cited by 92 · see citing works
Self-citationBurns, E. M., Kruckeberg, T. W., Comerford, L. E., & Buschmann, M. T. (1979) · Journal of Gerontology · doi:10.1093/geronj/34.5.642 · Cited by 84 · see citing works
Ischemic preconditioning: The role of mitochondria and aging
Wojtovich, A. P., Nadtochiy, S. M., Brookes, P. S., & Nehrke, K. W. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.11.001 · Cited by 79 · see citing works
Fabbri, E., Chia, C. W., Spencer, R. G., Fishbein, K. W., Reiter, D. A., Cameron, D., Zane, A. C., Moore, Z. A., Gonzalez-Freire, M., Zoli, M., et al. (2017) · Diabetes · doi:10.2337/db16-0754 · Cited by 76 · see citing works
Self-citationCsiszár, A., Yabluchanskiy, A., Ungvari, A., Ungvari, Z. I., & Tarantini, S. (2019) · GeroScience · doi:10.1007/s11357-019-00111-0 · Cited by 69 · see citing works
Zhao, W., Li, A., Feng, X., Hou, T., Liu, K., Liu, B., & Zhang, N. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.06.018 · Cited by 68 · see citing works
Prompers, J. J., Wessels, B., Kemp, G. J., & Nicolay, K. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.02.014 · Cited by 42 · see citing works
Adelnia, F., Urbanek, J. K., Osawa, Y., Shardell, M. D., Brennan, N. A., Fishbein, K. W., Spencer, R. G. S., Simonsick, E. M., Schrack, J. A., & Ferrucci, L. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15991 · Cited by 37 · see citing works
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Sorted by citations
Connecting aging biology and inflammation in the omics era
Walker, K. A., Basisty, N., Wilson, D. M., & Ferrucci, L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158448 · Cited by 189 · see citing works
Self-citationMitochondrial Dysfunction and Therapeutic Perspectives in Cardiovascular Diseases
Liu, Y., Huang, Y., Xu, C. B., An, P., Luo, Y., Jiao, L., Luo, J., & Li, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416053 · Cited by 149 · see citing works
Nyúl‐Tóth, Á., Tarantini, S., DelFavero, J., Yan, F., Balasubramanian, P., Yabluchanskiy, A., Ahire, C., Kiss, T., Csípő, T., Lipécz, Á., et al. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00709.2020 · Cited by 76 · see citing works
Geroscience and pathology: a new frontier in understanding age-related diseases
Fekete, M., Major, D., Fehér, Á., Fazekas‐Pongor, V., & Lehoczki, A. (2024) · Pathology & Oncology Research · doi:10.3389/pore.2024.1611623 · Cited by 64 · see citing works
Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease
Forman, D. E., Kuchel, G. A., Newman, J. C., Kirkland, J. L., Volpi, E., Taffet, G. E., Barzilai, N., Pandey, A., Kitzman, D. W., Libby, P., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.05.038 · Cited by 62 · see citing works
Self-citationCardiac ageing: from hallmarks to therapeutic opportunities
Hastings, M. H., Zhou, Q., Wu, C., Shabani, P., Huang, S., Yu, X., Singh, A. P., Guseh, J. S., Li, H., Lerchenmüller, C., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae124 · Cited by 39 · see citing works
Healthcare Management of Major Cardiovascular Disease-A review
Indhumathi, M., & Kumar, V. D. A. (2021) · International Conference on Inventive Computation Technologies (ICICT) · doi:10.1109/icict50816.2021.9358519 · Cited by 18 · see citing works
Sayed, R. K. A., Fernández‐Ortiz, M., Rahim, I., Fernández‐Martínez, J., Aranda‐Martínez, P., Rusanova, I., Martínez-Ruiz, L., Alsaadawy, R. M., Escames, G., & Acuña-Castroviejo, D. (2021) · Antioxidants · doi:10.3390/antiox10081269 · Cited by 16 · see citing works
Barbalho, S. M., Tofano, R. J., Chagas, E. F. B., Detregiachi, C. R. P., Goulart, R. D. Á., & Flato, U. A. P. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111302 · Cited by 12 · see citing works
Cardiovascular Dysfunction in Polycystic Ovary Syndrome: Mitochondrial and Inflammatory Mechanisms
Badejogbin, O. C., Agunloye, M. O., Chijioke‐Agu, O. E., Olubiyi, M. V., Olugbuyiro, S. O., Soetan, O. A., Bamgbose, O. A., & Olaleye, T. O. (2026) · BioMed Research International · doi:10.1155/bmri/1110229 · Cited by 6 · see citing works
Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
Delpino, M. V., & Quarleri, J. F. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1442323 · Cited by 5 · see citing works
Wu, X., Wang, Y., Ren, Z., Li, L., Qian, W., Chen, Y., & Ren, W. (2021) · International Journal of Endocrinology · doi:10.1155/2021/5921863 · Cited by 5 · see citing works
Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm
Cecati, M., Fumarola, S., Vaiasicca, S., Cianfruglia, L., Vignini, A., Giannubilo, S. R., Emanuelli, M., & Ciavattini, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030902 · Cited by 6 · see citing works
Pearson, R. C., Olenick, A., & Jenkins, N. T. (2023) · Kinesiology · doi:10.26582/k.55.2.7 · Cited by 3 · see citing works
Gonsalves, S. G., Saligan, L. N., Bergeron, C. M., Lee, P. R., Fishbein, K. W., Spencer, R. G. S., Zampino, M., Sun, X., Sheng, J. Y.-S., Stearns, V., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-52570-x · Cited by 3 · see citing works
Self-citationFranssen, W. M. A., Nieste, I., Koppo, K., Joris, P. J., Vandereyt, F., Savelberg, H. H. C. M., & Eijnde, B. O. (2026) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2025-002759 · Cited by 1 · see citing works
Rudroff, T. (2025) · Springer eBooks · doi:10.1007/978-3-031-89474-9_5
Juvenal, H., Gu, W., Zhao, Z., Pan, Y., Shi, Y., Li, S., Jiang, Y., Awad, M. A., Chen, S., Zhao, Y., et al. (2026) · Vascular Pharmacology · doi:10.1016/j.vph.2026.107691
Musculoskeletal markers of cardiorespiratory fitness in postmenopausal women
Mano, M. C. D. S., Santa-Clara, H., & Baptista, F. (2026) · Sport Sciences for Health · doi:10.1007/s11332-026-01926-z
Xing, X., Zhao, C., Li, M., Huang, J., Yu, C., Sun, W., 盂彦乔, Chen, X., Qiao, L., Li, Y., et al. (2026) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2026.100967
- Authors
- Zampino, M., Spencer, R. G., Fishbein, K. W., Simonsick, E. M., & Ferrucci, L.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Ferrucci, Luigi
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-11-29
- Volume
- 76
- Issue
- 2
- Pages
- 361-367
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC7812439
- OpenAlex
- W3108389900
- Cited by
- 20
- References
- 52
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 5
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- The Journals of Gerontology Series A (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- mitochondrial dysfunction, mitochondrial oxidative capacity, cardiovascular risk, phosphocreatine recovery, phosphorus magnetic resonance spectroscopy, skeletal muscle, Framingham risk score, cardiovascular disease history, aging, oxidative stress, energy metabolism
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Cardiovascular Diseases, Cardiovascular System, Female, Humans, Longitudinal Studies, Male, Middle Aged, Mitochondria, Muscle, Magnetic Resonance Spectroscopy, Oxidative Phosphorylation, Risk Factors, Baltimore, Multivariate Analysis, Linear Models, Oxidative Stress
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