Mitochondrial dysfunction in cardiovascular disease

Ballinger, Scott W.

doi:10.1016/j.freeradbiomed.2005.02.014

Cited by 406Mitochondrial Function and PathologyNitric Oxide and Endothelin EffectsCardiac Ischemia and Reperfusion

Mitochondrial dysfunction in cardiovascular disease

Ballinger, Scott W.·2005·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2005.02.014

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Abstract

Whereas the pathogenesis of atherosclerosis has been intensively studied and described, the underlying events that initiate cardiovascular disease are not yet fully understood. A substantial number of studies suggest that altered levels of oxidative and nitrosoxidative stress within the cardiovascular environment are essential in the development of cardiovascular disease; however, the impact of such changes on the subcellular or organellar components and their functions that are relevant to cardiovascular disease inception are less understood. In this regard, studies are beginning to show that mitochondria not only appear susceptible to damage mediated by increased oxidative and nitrosoxidative stress, but also play significant roles in the regulation of cardiovascular cell function. In addition, accumulating evidence suggests that a common theme among cardiovascular disease development and cardiovascular disease risk factors is increased mitochondrial damage and dysfunction. This review discusses aspects relating mitochondrial damage and function to cardiovascular disease risk factors and disease development.

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Activation of sGC by NO results in increased cGMP concentrations in platelets.
“This results in increased cGMP concentrations in platelets, and this is thought to be the mechanism by which platelet function is inhibited (108,109) .”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [109]
Increased cGMP concentrations in platelets are thought to be the mechanism by which platelet function is inhibited.
“This results in increased cGMP concentrations in platelets, and this is thought to be the mechanism by which platelet function is inhibited (108,109) .”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [109]

Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889 · see citing works
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Beyond Cholesterol
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425 · see citing works
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084 · see citing works
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451 · see citing works
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725 · see citing works
Mitochondrial diseases in man and mouse
Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060 · see citing works
Role of oxidized low density lipoprotein in atherogenesis.
Witztum, J. L., & Steinberg, D. H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115499 · Cited by 2,682 · see citing works
Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal Transduction
Sundaresan, M., Yu, Z.-X., Ferrans, V. J., Irani, K., & Finkel, T. (1995) · Science · doi:10.1126/science.270.5234.296 · Cited by 2,520 · see citing works
Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy
Wallace, D. C., Singh, G., Lott, M. T., Hodge, J. A., Schurr, T. G., Lezza, A. M. S., Elsas, L. J., & Nikoskelainen, E. K. (1988) · Science · doi:10.1126/science.3201231 · Cited by 2,440 · see citing works
A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies
Goto, Y.-I., Nonaka, I., & Horai, S. (1990) · Nature · doi:10.1038/348651a0 · Cited by 2,070 · see citing works
Free Radicals in Biology
Pryor, W. A. (1976) · Cited by 1,857 · see citing works
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
Yakes, F. M., & Van Houten, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.514 · Cited by 1,854 · see citing works
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765 · see citing works
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660 · see citing works
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652 · see citing works
Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence
Stampfer, M. J., & Colditz, G. A. (1991) · Preventive Medicine · doi:10.1016/0091-7435(91)90006-p · Cited by 1,611 · see citing works
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
Turrens, J. F., & Boveris, A. (1980) · Biochemical Journal · doi:10.1042/bj1910421 · Cited by 1,601 · see citing works
[10] Superoxide dismutase assays
Flohé, L., & Ötting, F. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05013-8 · Cited by 1,509 · see citing works
Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNALys mutation
Shoffner, J. M., Lott, M. T., Lezza, A. M. S., Seibel, P., Ballinger, S. W., & Wallace, D. C. (1990) · Cell · doi:10.1016/0092-8674(90)90059-n · Cited by 1,468 · see citing works
Self-citation
Biological Action of Leptin as an Angiogenic Factor
Sierra-Honigmann, M. R., Nath, A. K., Murakami, C., García‐Cardeña, G., Papapetropoulos, A., Sessa, W. C., Madge, L. A., Schechner, J. S., Schwabb, M. B., Polverini, P. J., et al. (1998) · Science · doi:10.1126/science.281.5383.1683 · Cited by 1,371 · see citing works
The role of oxidized lipoproteins in atherogenesis
Berliner, J. A., & Heinecke, J. W. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02173-6 · Cited by 1,365 · see citing works
Postmenopausal Estrogen and Progestin Use and the Risk of Cardiovascular Disease
Grodstein, F., Stampfer, M. J., Manson, J. E., Colditz, G. A., Willett, W. C., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1996) · New England Journal of Medicine · doi:10.1056/nejm199608153350701 · Cited by 1,294 · see citing works
Generation of reactive oxygen species by the mitochondrial electron transport chain
Liu, Y., Fiskum, G., & Schubert, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00744.x · Cited by 1,260 · see citing works
Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?
Wallace, D. C. (1992) · Science · doi:10.1126/science.1533953 · Cited by 1,256 · see citing works
Activation of Mitogen-activated Protein Kinase by H2O2
Guyton, K. Z., Liu, Y., Gorospe, M., Xu, Q., & Holbrook, N. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4138 · Cited by 1,212 · see citing works
Postmenopausal Hormone Therapy and Mortality
Grodstein, F., Stampfer, M. J., Colditz, G. A., Willett, W. C., Manson, J. E., Joffe, M. M., ROSNER, B. A., Fuchs, C. S., Hankinson, S. E., Hunter, D. J., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199706193362501 · Cited by 1,167 · see citing works
Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species
Ischiropoulos, H. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0755 · Cited by 1,024 · see citing works
A new mitochondrial disease associated with mitochondrial DNA heteroplasmy.
Holt, I. J., Harding, A. E., Petty, R., & MORGAN-HUGHES, J. A. (1990) · PubMed · Cited by 996 · see citing works
Oxidative Damage and Tyrosine Nitration from Peroxynitrite
Beckman, J. S. (1996) · Chemical Research in Toxicology · doi:10.1021/tx9501445 · Cited by 993 · see citing works
Postmenopausal Hormone Replacement Therapy: Scientific Review
Nelson, H. D., Humphrey, L. L., Nygren, P., Teutsch, S. M., & Allan, J. D. (2002) · JAMA · doi:10.1001/jama.288.7.872 · Cited by 990 · see citing works
Cell Biology of Atherosclerosis
Ross, R. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.004043 · Cited by 975 · see citing works
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.
Schulze‐Osthoff, K., Bakker, A. C., Vanhaesebroeck, B., Beyaert, R., Jacob, W. A., & Fiers, W. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42768-8 · Cited by 935 · see citing works
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age
Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., Flint Beal, M., & Wallace, D. C. (1992) · Nature Genetics · doi:10.1038/ng1292-324 · Cited by 890 · see citing works
3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
Hazen, S. L., & Heinecke, J. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119379 · Cited by 842 · see citing works
Adverse effects of reverse transcriptase inhibitors
Brinkman, K., ter Hofstede, H. J. M., Burger, D. M., Smeitink, J. A. M., & Koopmans, P. P. (1998) · AIDS · doi:10.1097/00002030-199814000-00004 · Cited by 839 · see citing works
Detection of a specific mitochondrial DNA deletion in tissues of older humans
Cortopassi, G. A., & Arnheim, N. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.23.6927 · Cited by 785 · see citing works
Hypertension and the Pathogenesis of Atherosclerosis
Alexander, R. W. (1995) · Hypertension · doi:10.1161/01.hyp.25.2.155 · Cited by 785 · see citing works
Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.
MacMillan-Crow, L.-A., Crow, J. P., Kerby, J. D., Beckman, J. S., & Thompson, J. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11853 · Cited by 768 · see citing works
Mitochondrial toxicity of antiviral drugs
Lewis, W., & Dalakas, M. C. (1995) · Nature Medicine · doi:10.1038/nm0595-417 · Cited by 766 · see citing works
Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction
Ide, T., Tsutsui, H., Hayashidani, S., Kang, D., Suematsu, N., Nakamura, K., Utsumi, H., Hamasaki, N., & Takeshita, A. (2001) · Circulation Research · doi:10.1161/01.res.88.5.529 · Cited by 733 · see citing works
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
Trounce, I., Byrne, E., & Marzuki, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92143-0 · Cited by 730 · see citing works
Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport
Cassina, A., & Radí, R. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0178 · Cited by 725 · see citing works
The oxidative inactivation of mitochondrial electron transport chain components and ATPase.
Zhang, Y., Marcillat, O., Giulivi, C., Ernster, L., & Davies, K. J. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46227-2 · Cited by 713 · see citing works
Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α
Cenci, S., Weitzmann, M. N., Roggia, C., Namba, N., Novack, D., Woodring, J., & Pacifici, R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11066 · Cited by 705 · see citing works
Leptin induces oxidative stress in human endothelial cells
Bouloumié, A., Marumo, T., Lafontan, M., & Busse, R. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.10.1231 · Cited by 679 · see citing works
Methods for detection of reactive metabolites of oxygen and nitrogen: In vitro and in vivo considerations
Tarpey, M. M., Wink, D. A., & Grisham, M. B. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00361.2003 · Cited by 673 · see citing works
The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis
Schreiber, S., Emter, R., Hock, M. B., Knutti, D., Cardenas, J., Podvinec, M., Oakeley, E. J., & Kralli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308686101 · Cited by 657 · see citing works
Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males
Borrás, C., Sastre, J., García-Sala, D., Lloret, A., Pallardó, F. V., & Viña, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01356-4 · Cited by 654 · see citing works
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.
Cortopassi, G. A., Shibata, D. K., Soong, N.-W., & Arnheim, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7370 · Cited by 639 · see citing works
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal
Devary, Y., Rosette, C., DiDonato, J. A., & Karin, M. (1993) · Science · doi:10.1126/science.8367725 · Cited by 637 · see citing works
Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pressure Stopped-Flow Technique, and Pulse Radiolysis
Kissner, R., Nauser, T., Bugnon, P., Lye, P. G., & Koppenol, W. H. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970160x · Cited by 629 · see citing works
Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A
Yamagishi, S., Edelstein, D., Du, X.-L., Kaneda, Y., Guzmán, M., & Brownlee, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007383200 · Cited by 620 · see citing works
Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B
McKenzie, R., Fried, M. W., Sallie, R., Conjeevaram, H., Di Bisceglie, A. M., Park, Y., Savarese, B., Kleiner, D., Tsokos, M., Luciano, C., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510263331702 · Cited by 616 · see citing works
Modulation of Oxidant Stress In Vivo in Chronic Cigarette Smokers
Reilly, M., Delanty, N., Lawson, J. A., & FitzGerald, G. A. (1996) · Circulation · doi:10.1161/01.cir.94.1.19 · Cited by 612 · see citing works
Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion
Ballinger, S. W., Shoffner, J. M., Hedaya, E. V., Trounce, I. A., Polak, M. A., Koontz, D. A., & Wallace, D. C. (1992) · Nature Genetics · doi:10.1038/ng0492-11 · Cited by 606 · see citing works
Self-citation
Myeloperoxidase-generated oxidants and atherosclerosis
Podrez, E. A., Abu‐Soud, H. M., & Hazen, S. L. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00229-x · Cited by 605 · see citing works
Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries: Regulation by Angiotensin II
Touyz, R. M., Chen, X., Tabet, F., Yao, G., He, G., Quinn, M. T., Pagano, P. J., & Schiffrin, E. L. (2002) · Circulation Research · doi:10.1161/01.res.0000020404.01971.2f · Cited by 590 · see citing works
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene‐inductive effects of TNF.
Schulze‐Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G., & Fiers, W. C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05978.x · Cited by 577 · see citing works
Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1
Manna, S. K., Zhang, H. J., Yan, T., Oberley, L. W., & Aggarwal, B. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13245 · Cited by 563 · see citing works
The Role of Endothelium in Cardiovascular Homeostasis and Diseases
Rubanyi, G. M. (1993) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199322004-00002 · Cited by 561 · see citing works
Angiotensin II Stimulates Endothelial Vascular Cell Adhesion Molecule-1 via Nuclear Factor-κB Activation Induced by Intracellular Oxidative Stress
Pueyo, M. E., Gonzalez, W., Nicoletti, A., Savoie, F., Arnal, J., & Michel, J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.645 · Cited by 516 · see citing works
The missing link: A single unifying mechanism for diabetic complications
Nishikawa, T., Edelstein, D., & Brownlee, M. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.07705.x · Cited by 512 · see citing works
Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues
MacMillan-Crow, L. A., Crow, J. P., & Thompson, J. A. (1998) · Biochemistry · doi:10.1021/bi971894b · Cited by 508 · see citing works
Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy
Arnaudo, E., Shanske, S., DiMauro, S., Schon, E. A., Moraes, C. T., Schon, E. A., & Dalakas, M. C. (1991) · The Lancet · doi:10.1016/0140-6736(91)91294-5 · Cited by 504 · see citing works
Mitochondrial localization of estrogen receptor β
Yang, S.-H., Liu, R., Perez, E., Wen, Y., Stevens, S. M., Valencia, T. G., Brun‐Zinkernagel, A., Prókai, L., Will, Y., Dykens, J. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306948101 · Cited by 501 · see citing works
Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice
Praticò, D., Tangirala, R. K., Rader, D. J., Rokach, J., & FitzGerald, G. A. (1998) · Nature Medicine · doi:10.1038/2685 · Cited by 501 · see citing works
Heteroplasmic mtDNA mutation (T----G) at 8993 can cause Leigh disease when the percentage of abnormal mtDNA is high.
Tatuch, Y., Christodoulou, J., Feigenbaum, A., Clarke, J. T. R., Wherret, J., Smith, C., Rudd, N., Petrova-Benedict, R., & Robinson, B. H. (1992) · PubMed · Cited by 483 · see citing works
Mitochondrial Integrity and Function in Atherogenesis
Ballinger, S. W., Patterson, C., Knight-Lozano, C. A., Burow, D. L., Conklin, C. A., Hu, Z., Reuf, J., Horaist, C., Lebovitz, R. M., Hunter, G. C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000023921.93743.89 · Cited by 478 · see citing works
Self-citation
Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane
LAMBERT, A. J., & BRAND, M. D. (2004) · Biochemical Journal · doi:10.1042/bj20040485 · Cited by 470 · see citing works
Reactive Nitrogen Intermediates Promote Low Density Lipoprotein Oxidation in Human Atherosclerotic Intima
Leeuwenburgh, C., Hardy, M. M., Hazen, S. L., Wagner, P. D., Oh‐ishi, S., Steinbrecher, U. P., & Heinecke, J. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1433 · Cited by 461 · see citing works
Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress
McNally, J. S., Davis, M. E., Giddens, D. P., Saha, A., Hwang, J., Dikalov, S., Jo, H., & Harrison, D. G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00515.2003 · Cited by 461 · see citing works
Elevated Levels of Oxidative DNA Damage and DNA Repair Enzymes in Human Atherosclerotic Plaques
Martinet, W., Knaapen, M., Meyer, G. R. Y. D., Herman, A. G., & Kockx, M. M. (2002) · Circulation · doi:10.1161/01.cir.0000026393.47805.21 · Cited by 448 · see citing works
Hydrogen Peroxide– and Peroxynitrite-Induced Mitochondrial DNA Damage and Dysfunction in Vascular Endothelial and Smooth Muscle Cells
Ballinger, S. W., Patterson, C., Yan, C.-N., Doan, R., Burow, D. L., Young, C. G., Yakes, F. M., Houten, B. V., Ballinger, C. A., Freeman, B. Α., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.9.960 · Cited by 442 · see citing works
Self-citation
Consequences of the diabetic status on the oxidant/antioxidant balance.
Bonnefont‐Rousselot, D., Bastard, J., Jaudon, M. C., & Delattre, J. (2000) · PubMed · Cited by 429 · see citing works
Expression of phagocyte NADPH oxidase components in human endothelial cells
Jones, S. A., O’Donnell, V. B., Wood, J. D., Broughton, J. P., Hughes, E. J., & Jones, O. T. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.4.h1626 · Cited by 427 · see citing works
Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium
Ide, T., Tsutsui, H., Kinugawa, S., Suematsu, N., Hayashidani, S., Ichikawa, K., Utsumi, H., Machida, Y., Egashira, K., & Takeshita, A. (2000) · Circulation Research · doi:10.1161/01.res.86.2.152 · Cited by 427 · see citing works
The epidemiology of coronary heart disease and estrogen replacement in postmenopausal women
Grodstein, F., & Stampfer, M. J. (1995) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(95)80012-3 · Cited by 417 · see citing works
Differential Activation of Mitogen-Activated Protein Kinases by H 2 O 2 and O 2 − in Vascular Smooth Muscle Cells
Baas, A. S., & Berk, B. C. (1995) · Circulation Research · doi:10.1161/01.res.77.1.29 · Cited by 416 · see citing works
Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
Yan, L.-J., & Sohal, R. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.12896 · Cited by 414 · see citing works
Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor α and estrogen receptor β
Nadal, Á., Ropero, A. B., Laribi, O., Maillet, M., Fuentes, E., & Soria, B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11603 · Cited by 371 · see citing works
Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.
Halliwell, B. B. (1989) · PubMed · Cited by 368 · see citing works
Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.
White, C. R., Darley-Usmar, V, Berrington, W. R., McAdams, M., Gore, J. Z., Thompson, J. A., Parks, D. A., Tarpey, M. M., & Freeman, B. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8745 · Cited by 367 · see citing works
Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease
Corral‐Debrinski, M., Shoffner, J. M., Lott, M. T., & Wallace, D. C. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90021-g · Cited by 360 · see citing works
Cytochrome c Nitration by Peroxynitrite
Cassina, A. M., Hodara, R., Souza, J. M., Thomson, L., Castro, L., Ischiropoulos, H., Freeman, B. A., & Radi, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909978199 · Cited by 354 · see citing works
Overexpression of MnSOD Protects Against Myocardial Ischemia/reperfusion Injury in Transgenic Mice
Chen, Z., Siu, B., Ho, Y., Vincent, R., Chua, C. C., Hamdy, R. C., & Chua, B. H. L. (1998) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1998.0789 · Cited by 346 · see citing works
Hypoxemia is associated with mitochondrial DNA damage and gene induction. Implications for cardiac disease
Corral‐Debrinski, M. (1991) · JAMA · doi:10.1001/jama.266.13.1812 · Cited by 341 · see citing works
The risk of acute myocardial infarction after oestrogen and oestrogen‐progestogen replacement
Falkeborn, M., Persson, I. R., Adami, H., Bergström, R., Eaker, E. D., Lithell, H., Mohsen, R., & Naessén, T. (1992) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1992.tb14414.x · Cited by 334 · see citing works
Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
Jabůrek, M., Vařecha, M., Gimeno, R. E., Dembski, M., Ježek, P., Zhang, M., Burn, P., Tartaglia, L. A., & Garlid, K. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26003 · Cited by 321 · see citing works
NADH Oxidase Activation Is Involved in Arsenite-Induced Oxidative DNA Damage in Human Vascular Smooth Muscle Cells
Lynn, S., Gurr, J.-R., Lai, H., & Jan, K.-Y. (2000) · Circulation Research · doi:10.1161/01.res.86.5.514 · Cited by 321 · see citing works
Uncoupling Protein-2 Overexpression Inhibits Mitochondrial Death Pathway in Cardiomyocytes
Teshima, Y., Akao, M., Jones, S. P., & Marbán, E. (2003) · Circulation Research · doi:10.1161/01.res.0000085581.60197.4d · Cited by 318 · see citing works
Postmenopausal Hormone Replacement Therapy and the Primary Prevention of Cardiovascular Disease
Humphrey, L. L., Chan, B. K. S., & Sox, H. C. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-4-200208200-00012 · Cited by 318 · see citing works
Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium
Lantin-Hermoso, R. L., Rosenfeld, C. R., Yuhanna, I. S., German, Z., Chen, Z., & Shaul, P. W. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.273.1.l119 · Cited by 284 · see citing works
Superoxide Radical and Hydrogen Peroxide in Mitochondria
Forman, H. J., & Boveris, A. (1982) · Elsevier eBooks · doi:10.1016/b978-0-12-566505-6.50010-7 · Cited by 273 · see citing works
Mitochondrial localization of ERα and ERβ in human MCF7 cells
Chen, J. Q., Delannoy, M., Cooke, C., & Yager, J. D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00508.2003 · Cited by 272 · see citing works
Increased Formation of Distinct F2Isoprostanes in Hypercholesterolemia
Reilly, M. P., Praticò, D., Delanty, N., DiMinno, G., Tremoli, E., Rader, D. J., Kapoor, S. C., Rokach, J., Lawson, J. A., & FitzGerald, G. A. (1998) · Circulation · doi:10.1161/01.cir.98.25.2822 · Cited by 271 · see citing works
Eosinophil peroxidase nitrates protein tyrosyl residues
Wu, W., Chen, Y., & Hazen, S. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25933 · Cited by 265 · see citing works
Nitric Oxide Modulates Superoxide Release and Peroxynitrite Formation in Human Blood Vessels
Guzik, T. J., West, N. E. J., Pillai, R. G., Taggart, D. P., & Channon, K. M. (2002) · Hypertension · doi:10.1161/01.hyp.0000018041.48432.b5 · Cited by 264 · see citing works
Biological Gradient Between Long-Term Arsenic Exposure and Carotid Atherosclerosis
Wang, C., Jeng, J., Yip, P.-K., Chen, C., Hsu, L.-I., Hsueh, Y., Chiou, H., Wu, M. M., & Chen, C. (2002) · Circulation · doi:10.1161/01.cir.0000015862.64816.b2 · Cited by 262 · see citing works
Mechanism of estrogen-mediated neuroprotection: Regulation of mitochondrial calcium and Bcl-2 expression
Nilsen, J., & Brinton, R. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438041100 · Cited by 262 · see citing works
Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes
Schulze‐Osthoff, K., Łoś, M., & Baeuerle, P. A. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)02011-z · Cited by 257 · see citing works
Protective Role of Uncoupling Protein 2 in Atherosclerosis
Blanc, J., Alves‐Guerra, M., Esposito, B., Rousset, S., Gourdy, P., Ricquier, D., Tedgui, A., Miroux, B., & Mallat, Z. (2003) · Circulation · doi:10.1161/01.cir.0000051722.66074.60 · Cited by 239 · see citing works
A new mtDNA mutation in the tRNA(Lys) gene associated with myoclonic epilepsy and ragged-red fibers (MERRF).
Silvestri, G., Moraes, C. T., Shanske, S., Oh, S. J., & DiMauro, S. (1992) · PubMed · Cited by 227 · see citing works
The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions
Nedergaard, J., & Cannon, B. (2003) · Experimental Physiology · doi:10.1113/eph8802502 · Cited by 226 · see citing works
IPF 2α -I: An index of lipid peroxidation in humans
Praticò, D., Barry, Ó. P., Lawson, J. A., Adiyaman, M., Hwang, S., Khanapure, S. P., Iuliano, L., Rokach, J., & FitzGerald, G. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3449 · Cited by 219 · see citing works
Cigarette Smoke Exposure and Hypercholesterolemia Increase Mitochondrial Damage in Cardiovascular Tissues
Knight-Lozano, C. A., Young, C. G., Burow, D. L., Hu, Z., Uyeminami, D. L., Pinkerton, K. E., Ischiropoulos, H., & Ballinger, S. W. (2002) · Circulation · doi:10.1161/hc0702.103977 · Cited by 217 · see citing works
Self-citation
Effect of Glutathione Depletion on Sites and Topology of Superoxide and Hydrogen Peroxide Production in Mitochondria
Han, D., Canali, R., Rettori, D., & Kaplowitz, N. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.5.1136 · Cited by 212 · see citing works
A Mitochondrial Paradigm for Degenerative Diseases and Ageing
Wallace, D. C. (2001) · Novartis Foundation symposium · doi:10.1002/0470868694.ch20 · Cited by 210 · see citing works
Hydrogen Peroxide Causes Significant Mitochondrial DNA Damage in Human RPE Cells
Ballinger, S. W., Houten, B. V., Conklin, C. A., Jin, G., & Godley, B. F. (1999) · Experimental Eye Research · doi:10.1006/exer.1998.0661 · Cited by 209 · see citing works
Self-citation
Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway
Yao, P. M., & Tabas, I. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101419200 · Cited by 204 · see citing works
Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria.
Lewis, W., Gonzalez, B. I., Chomyn, A., & Papoian, T. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115722 · Cited by 204 · see citing works
c-Jun N-terminal Kinase Activation by Hydrogen Peroxide in Endothelial Cells Involves Src-dependent Epidermal Growth Factor Receptor Transactivation
Chen, K., Vita, J. A., Berk, B. C., & Keaney, J. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011766200 · Cited by 200 · see citing works
Chemical and biochemical aspects of superoxide and superoxide dismutase
Gutteridge, J. M. C. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)81108-8 · Cited by 197 · see citing works
Amelioration of Ischemia- and Reperfusion-Induced Myocardial Injury by 17β-Estradiol
Node, K., Kitakaze, M., Kosaka, H., Minamino, T., Funaya, H., & Hori, M. (1997) · Circulation · doi:10.1161/01.cir.96.6.1953 · Cited by 178 · see citing works
α-Tocopherol Decreases Superoxide Anion Release in Human Monocytes Under Hyperglycemic Conditions Via Inhibition of Protein Kinase C-α
Venugopal, S. K., Devaraj, S., Yang, T., & Jialal, I. (2002) · Diabetes · doi:10.2337/diabetes.51.10.3049 · Cited by 176 · see citing works
Maternal Hypercholesterolemia During Pregnancy Promotes Early Atherogenesis in LDL Receptor-Deficient Mice and Alters Aortic Gene Expression Determined by Microarray
Claudio Napoli, A., de Nigris, F., Welch, J. S., Calara, F. B., Stuart, R. O., Glass, C. K., & Palinski, W. (2002) · Circulation · doi:10.1161/hc1102.106792 · Cited by 174 · see citing works
Oxidative DNA Damage and Repair in Experimental Atherosclerosis Are Reversed by Dietary Lipid Lowering
Martinet, W., Knaapen, M., Meyer, G. R. Y. D., Herman, A. G., & Kockx, M. M. (2001) · Circulation Research · doi:10.1161/hh0701.088684 · Cited by 171 · see citing works
Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle
Sreekumar, R., Unnikrishnan, J., Fu, A., Nygren, J., Short, K. R., Schimke, J., Barazzoni, R., & Nair, K. S. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00387.2001 · Cited by 170 · see citing works
Mitochondrial proton leak and the uncoupling protein 1 homologues
Stuart, J. A., Cadenas, S., Jekabsons, M. B., Roussel, D., & Brand, M. D. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00243-7 · Cited by 169 · see citing works
Improvement of the Mitochondrial Antioxidant Defense Status Prevents Cytokine-Induced Nuclear Factor-κB Activation in Insulin-Producing Cells
Azevedo‐Martins, A. K., Lortz, S., Lenzen, S., Curi, R., Eizirik, D. L., & Tiedge, M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.93 · Cited by 165 · see citing works
Passive Smoking Affects Endothelium and Platelets
Davis, J. W. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.1989.00390020096020 · Cited by 164 · see citing works
Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure
Hsueh, Y.-M., Wu, W.-L., Huang, Y.-L., Chiou, H.-Y., Tseng, C.-H., & Chen, C.-J. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00178-6 · Cited by 159 · see citing works
Subacute necrotizing encephalopathy
Shoffner, J. M., Fernhoff, P. M., Krawiecki, N., Caplan, D. B., Holt, P., Koontz, D. A., Takei, Y., Newman, N. J., Ortiz, R. G., Polak, M., et al. (1992) · Neurology · doi:10.1212/wnl.42.11.2168 · Cited by 154 · see citing works
Self-citation
FIBRE, DIABETES, AND HYPERLIPIDÆMIA
Mann, J. I., Simpson, H. C. R., & Yudkin, J. S. (1980) · The Lancet · doi:10.1016/s0140-6736(80)90581-4 · Cited by 153 · see citing works
Mitochondria, nitric oxide, and cardiovascular dysfunction
Ramachandran, A., Levonen, A., Brookes, P. S., CEASER, E. K., Shiva, S., Barone, M. C., & Darley-Usmar, V. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01142-5 · Cited by 149 · see citing works
Mitochondrial Theory of Aging: Importance to Explain Why Females Live Longer Than Males
Viña, J., Sastre, J., Pallardó, F. V., & Borrás, C. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310194 · Cited by 145 · see citing works
Reactive Oxygen Species Are Involved in Arsenic Trioxide Inhibition of Pyruvate Dehydrogenase Activity
Samikkannu, T., Chen, C., Yih, L., Wang, A. S. S., Lin, S., Chen, T., & Jan, K.-Y. (2003) · Chemical Research in Toxicology · doi:10.1021/tx025615j · Cited by 143 · see citing works
Binding of MCF‐7 cell mitochondrial proteins and recombinant human estrogen receptors α and β to human mitochondrial dna estrogen response elements
Chen, J. Q., Eshete, M., Alworth, W. L., & Yager, J. D. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20178 · Cited by 142 · see citing works
Nitrite as a Substrate and Inhibitor of Myeloperoxidase
van Dalen, C. J., Winterbourn, C. C., Senthilmohan, R., & Kettle, A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11638 · Cited by 139 · see citing works
[4] Measuring nitric oxide and superoxide: Rate constants for aconitase reactivity
Hausladen, A., & Fridovich, I. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)69007-7 · Cited by 137 · see citing works
Induction of Nuclear Factor κB after Low-Dose Ionizing Radiation Involves a Reactive Oxygen Intermediate Signaling Pathway
Mohan, N., & Meltz, M. L. (1994) · Radiation Research · doi:10.2307/3578574 · Cited by 134 · see citing works
Effects of tobacco smoke and benzo[a]pyrene on human endothelial cell and monocyte stress responses
Vayssier‐Taussat, M., Camilli, T. C., Aron, Y., Méplan, C., Hainaut, P. L., Polla, B. S., & Weksler, B. B. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.3.h1293 · Cited by 133 · see citing works
Oxidative Damage to Human Lens Epithelial Cells in Culture: Estrogen Protection of Mitochondrial Potential, ATP, and Cell Viability
Wang, X., Simpkins, J. W., Dykens, J. A., & Cammarata, P. R. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0841 · Cited by 133 · see citing works
Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3
Talbot, D. A., Lambert, A. J., & Brand, M. D. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01386-3 · Cited by 131 · see citing works
Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) mice.
Simeonova, P. P., Hulderman, T., Harki, D. A., & Luster, M. I. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6332 · Cited by 127 · see citing works
Postischemic Recovery of Contractile Function is Impaired in SOD2 +/− but Not SOD1 +/− Mouse Hearts
Asimakis, G. K., Lick, S. D., & Patterson, C. (2002) · Circulation · doi:10.1161/hc0802.104502 · Cited by 125 · see citing works
Oxidized LDL Promotes Peroxide-Mediated Mitochondrial Dysfunction and Cell Death in Human Macrophages
Asmis, R., & Begley, J. G. (2003) · Circulation Research · doi:10.1161/01.res.0000051886.43510.90 · Cited by 117 · see citing works
Mitochondrial Function Is Required for Hydrogen Peroxide-induced Growth Factor Receptor Transactivation and Downstream Signaling
Chen, K., Thomas, S. R., Albano, A., Murphy, M. P., & Keaney, J. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404859200 · Cited by 116 · see citing works
Inhalation of steady-state sidestream smoke from one cigarette promotes arteriosclerotic plaque development.
Penn, A. L., Chen, L., & Snyder, C. A. (1994) · Circulation · doi:10.1161/01.cir.90.3.1363 · Cited by 116 · see citing works
Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins
Yan, L., & Sohal, R. S. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00423-8 · Cited by 115 · see citing works
Subcellular distribution of native estrogen receptor α and β isoforms in rabbit uterus and ovary
Monje, P. V., & Boland, R. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1182 · Cited by 114 · see citing works
Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle
Sreekumar, R., Unnikrishnan, J., Fu, A., Nygren, J., Short, K. R., Schimke, J., Barazzoni, R., & Nair, K. S. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00554.2001 · Cited by 114 · see citing works
Mechanisms of Cell Signaling by Nitric Oxide and Peroxynitrite: From Mitochondria to MAP Kinases
Levonen, A., Patel, R. P., Brookes, P. S., Go, Y., Jo, H., Parthasarathy, S., Anderson, P. G., & Darley-Usmar, V. M. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601300185188 · Cited by 112 · see citing works
Estrogen Regulation of Endothelial and Smooth Muscle Cell Migration and Proliferation
Geraldes, P., Sirois, M. G., Bernatchez, P. N., & Tanguay, J. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000035393.11854.6a · Cited by 112 · see citing works
Protein oxidation of cytochrome c by reactive halogen species enhances its peroxidase activity
Chen, Y.-R., Deterding, L. J., Sturgeon, B. E., Tomer, K. B., & Mason, R. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200709200 · Cited by 110 · see citing works
A Reappraisal of Xanthine Dehydrogenase and Oxidase in Hypoxic Reperfusion Injury: the Role of NADH as an Electron Donor
Zhang, Z., Blake, D. R., Stevens, C. R., Kanuler, J. M., Ward, P. G., Symons, M. C. R., Benboubetra, M., & Harrison, R. (1998) · Free Radical Research · doi:10.3109/10715769809065801 · Cited by 110 · see citing works
Chemical and biochemical aspects of superoxide and superoxide dismutase
Bannister, J. V., & Hill, H. A. O. (1980) · Elsevier eBooks · Cited by 109 · see citing works
Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus: an hypothesis
Watts, G. F., & Playford, D. A. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00170-1 · Cited by 107 · see citing works
Induction of mitochondrial manganese superoxide dismutase in macrophages by oxidized LDL: its relevance in atherosclerosis of humans and heritable hyperlipidemic rabbits
Kinscherf, R., Deigner, H., Usinger, C., Pill, J., Wagner, M., Kamencic, H., Hou, D., Chen, M., Schmiedt, W., Schrader, M., et al. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.14.9409551 · Cited by 105 · see citing works
Cardioprotective Effects of 17β-Estradiol Produced by Activation of Mitochondrial ATP-Sensitive K+Channels in Canine Hearts
Lee, T., Su, S., Tsai, C.-C., Lee, Y., & Tsai, C. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1167 · Cited by 105 · see citing works
17β-Estradiol Prevents Dysfunction of Canine Coronary Endothelium and Myocardium and Reperfusion Arrhythmias After Brief Ischemia/Reperfusion
Kim, Y. D., Chen, B., Beauregard, J. F., Kouretas, P. C., Thomas, G. R., Farhat, M. Y., Myers, A. K., & Lees, D. E. (1996) · Circulation · doi:10.1161/01.cir.94.11.2901 · Cited by 103 · see citing works
A Deletion of Mitochondrial DNA in Murine Doxorubicin-Induced Cardiotoxicity
Adachi, K., Fujiura, Y., Mayumi, F., Nozuhara, A., Sugiu, Y., Sakanashi, T., Hidaka, T., & Toshima, H. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2135 · Cited by 103 · see citing works
Estradiol attenuates directed migration of vascular smooth muscle cells in vitro.
Kolodgie, F. D., Jacob, A., Wilson, P. S., Carlson, G. C., Farb, A. A., Verma, A., & Virmani, R. (1996) · Europe PMC (PubMed Central) · Cited by 102 · see citing works
DNA Damage as a New Emerging Risk Factor in Atherosclerosis
Andreassi, M. G., & Botto, N. (2003) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(03)00109-9 · Cited by 102 · see citing works
Relationship between oxidative phosphorylation and adenine nucleotide translocase activity of two populations of cardiac mitochondria and mechanical recovery of ischemic hearts following reperfusion
Duan, J., & Karmazyn, M. (1989) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y89-114 · Cited by 101 · see citing works
Estrogen's Effects on Mitochondrial Gene Expression: Mechanisms and Potential Contributions to Estrogen Carcinogenesis
CHEN, J., & Yager, J. D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1322.030 · Cited by 92 · see citing works
17β-Estradiol as a Receptor-Mediated Cardioprotective Agent
Booth, E. A., Marchesi, M., Kilbourne, E. J., & Lucchesi, B. R. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054205 · Cited by 90 · see citing works
Atherosclerotic Lesions and Mitochondria DNA Deletions in Brain Microvessels as a Central Target for the Development of Human AD and AD‐Like Pathology in Aged Transgenic Mice
Aliev, G. M., Seyidova, D., Neal, M. L., Shi, J., Lamb, B. T., Siedlak, S. L., Vinters, H. V., Head, E., Perry, G. L., LaManna, J. C., et al. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04798.x · Cited by 89 · see citing works
Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration
Castro, L., Eiserich, J. P., Sweeney, S., Radi, R., & Freeman, B. A. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.033 · Cited by 84 · see citing works
Mitochondrial toxicity–new adverse drug effects
Swartz, M. N. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510263331710 · Cited by 80 · see citing works
Circulating Xanthine Oxidase in Human Ischemia Reperfusion
Tan, S., Gelman, S., Wheat, J. K., & Parks, D. A. (1995) · Southern Medical Journal · doi:10.1097/00007611-199504000-00021 · Cited by 76 · see citing works
Estradiol reverses TGF-β1-stimulated type IV collagen gene transcription in murine mesangial cells
SILBIGER, S. R., Lei, J., Ziyadeh, F. N., & Neugarten, J. (1998) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1998.274.6.f1113 · Cited by 75 · see citing works
Mitochondrial Function Is Involved in LDL Oxidation Mediated by Human Cultured Endothelial Cells
Mabile, L., Meilhac, O., Escargueil‐Blanc, I., Troly, M., Pieraggi, M., Salvayre, R., & Nègre‐Salvayre, A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.8.1575 · Cited by 74 · see citing works
Cytotoxicity of oxidized low‐density lipoprotein to mouse peritoneal macrophages: An ultrastructural study
Reid, V. C., Mitchinson, M. J., & Skepper, J. N. (1993) · The Journal of Pathology · doi:10.1002/path.1711710413 · Cited by 73 · see citing works
DNA-adducts and atherosclerosis: a study of accidental and sudden death males in the Czech Republic
Binková, B., Šmerhovský, Z., Strejc, P., Boubelík, O., Stávková, Z., Chvátalová, I., & Šrám, R. J. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00019-2 · Cited by 72 · see citing works
Decreased Superoxide Dismutase Activity and Increased Superoxide Anion Production in Cardiac Hypertrophy of Spontaneously Hypertensive Rats
Ito, H., Torii, M., & Suzuki, T. (1995) · Clinical and Experimental Hypertension · doi:10.3109/10641969509033636 · Cited by 72 · see citing works
Oxygen Radical-Nitric Oxide Reactions in Vascular Diseases
Freeman, B. Α., White, C. R., Gutierrez, H. H., Paler-Martı́nez, A., Tarpey, M. M., & Rubbo, H. (1995) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61080-7 · Cited by 71 · see citing works
Smoke cardiomyopathy: disturbance of oxidative processes in myocardial mitochondria
Gvozdjáková, A., Bada, V., Sány, L., Kucharská, J., Krutý, F., Božek, P., TRSTANSKY, L., & Gvozdják, J. (1984) · Cardiovascular Research · doi:10.1093/cvr/18.4.229 · Cited by 71 · see citing works
Mechanism of uncoupling protein action
Garlid, K., Jabůrek, M., & Ježek, P. (2001) · Biochemical Society Transactions · doi:10.1042/0300-5127:0290803 · Cited by 69 · see citing works
Estrogen for women at varying risk of coronary disease
Grodstein, F., & Stampfer, M. J. (1998) · Maturitas · doi:10.1016/s0378-5122(98)00055-3 · Cited by 68 · see citing works
Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: Role of mitochondrial respiratory complexes and heat shock proteins
Ramachandran, A., CEASER, E. K., & Darley-Usmar, V. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304653101 · Cited by 67 · see citing works
Effect of Smoking on the Oxidative Processes of Cardiomyocytes
Gvozdjáková, A., Kucharská, J., & Gvozdják, J. (2008) · Cardiology · doi:10.1159/000175780 · Cited by 66 · see citing works
Oxidative Stress and Antioxidant Supplementation in the Management of Diabetic Cardiovascular Disease
Vega‐López, S., Devaraj, S., & Jialal, I. (2004) · Journal of Investigative Medicine · doi:10.1136/jim-52-01-23 · Cited by 65 · see citing works
Mechanism of uncoupling protein action
Garlid, K., Jabůrek, M., & Ježek, P. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290803 · Cited by 64 · see citing works
Distribution and prevalence of inducible nitric oxide synthase in atherosclerotic vessels of long-term cholesterol-fed rabbits
Behr‐Roussel, D., Rupin, A., Fabiani, J., & Verbeuren, T. J. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00254-8 · Cited by 63 · see citing works
Stable transfection of UCP1 confers resistance to hypoxia/reoxygenation in a heart-derived cell line
Bienengraeber, M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00147-0 · Cited by 62 · see citing works
Increased Sensitivity of Mitochondrial Respiration to Inhibition by Nitric Oxide in Cardiac Hypertrophy
Brookes, P. S., Zhang, J., Dai, L., Zhou, F., Parks, D. A., Darley-Usmar, V. M., & Anderson, P. G. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1276 · Cited by 61 · see citing works
Differential cellular localization of estrogen receptor α in uterine and mammary cells
Monje, P. V., Zanello, S. B., Holick, M. F., & Boland, R. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00526-3 · Cited by 60 · see citing works
High incidence of pre‐excitation syndrome in Japanese families with Leber's hereditary optic neuropathy
Mashima, Y., Kigasawa, K., Hasegawa, H., Tani, M., & Oguchi, Y. (1996) · Clinical Genetics · doi:10.1111/j.1399-0004.1996.tb02732.x · Cited by 60 · see citing works
Ischemia- and reperfusion-induced ventricular arrhythmias in dogs: effects of estrogen
McHugh, N. A., Cook, S., Schairer, J. L., Bidgoli, M. M., & Merrill, G. F. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.6.h2569 · Cited by 60 · see citing works
Prenatal Environmental Tobacco Smoke Exposure Promotes Adult Atherogenesis and Mitochondrial Damage in Apolipoprotein E −/− Mice Fed a Chow Diet
Yang, Z., Knight, C. A., Mamerow, M. M., Vickers, K. C., Penn, A. L., Postlethwait, E. M., & Ballinger, S. W. (2004) · Circulation · doi:10.1161/01.cir.0000149747.82157.01 · Cited by 59 · see citing works
Self-citation
Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice
Nedergaard, J., Golozoubova, V., Matthias, A., Shabalina, I. G., Ohba, K., Ohlson, K. B. E., Jacobsson, A., & Cannon, B. (2001) · Biochemical Society Transactions · doi:10.1042/0300-5127:0290756 · Cited by 59 · see citing works
Inhibition of mitochondrial protein synthesis results in increased endothelial cell susceptibility to nitric oxide-induced apoptosis
Ramachandran, A., Moellering, D. R., CEASER, E. K., Shiva, S., Xu, J., & Darley-Usmar, V. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102019899 · Cited by 57 · see citing works
Growth Regulatory Mechanisms and Formation of the Lesions of Atherosclerosisa
Ross, R. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb17304.x · Cited by 56 · see citing works
Oxidized low-density lipoprotein and 15-deoxy-Δ12,14-PGJ2increase mitochondrial complex I activity in endothelial cells
CEASER, E. K., Ramachandran, A., Levonen, A., & Darley-Usmar, V. M. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00508.2003 · Cited by 55 · see citing works
Differential Effects of Sarcolemmal and Mitochondrial KATP Channels Activated by 17β-Estradiol on Reperfusion Arrhythmias and Infarct Sizes in Canine Hearts
Tsai, C., Su, S., Chou, T., & Lee, T. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.1.234 · Cited by 54 · see citing works
PRE-EXCITATION SYNDROME AND LEBER'S HEREDITARY OPTIC NEURORETINOPATHY
Nikoskelainen, E. K., Wanne, O., & Dahl, M. R. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91354-6 · Cited by 53 · see citing works
The relation of oxidative DNA damage to hypertension and other cardiovascular risk factors in Tanzania
Negishi, H., Ikeda, K., Kuga, S., Noguchi, T., Kanda, T., Njelekela, M. A., Liu, L., Miki, T., Nara, Y., Sato, T., et al. (2001) · Journal of Hypertension · doi:10.1097/00004872-200103001-00002 · Cited by 53 · see citing works
Cardioprotection by chronic estrogen or superoxide dismutase mimetic treatment in the aged female rat
Xu, Y., Armstrong, S. J., Arenas, I. A., Pehowich, D. J., & Davidge, S. T. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00037.2004 · Cited by 50 · see citing works
Life without UCPI: mitochondrial, cellular and organismal characteristics of the UCPI-ablated mice
Nedergaard, J., Golozoubova, V., Matthias, A., Shabalina, I. G., Ohba, K., Ohlson, K. B. E., Jacobsson, A., & Cannon, B. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290756 · Cited by 49 · see citing works
Atherosclerosis in AIDS: Potential Pathogenetic Roles of Antiretroviral Therapy and HIV
Lewis, W. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1271 · Cited by 47 · see citing works
Uncoupling protein 3 and fatty acid metabolism
Dulloo, A. G., Samec, S., & Seydoux, J. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290785 · Cited by 46 · see citing works
Uncoupling protein, H+ transport and regulation
Klingenberg, M., Winkler, E., & Echtay, K. S. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290806 · Cited by 45 · see citing works
Increased circulating leptin concentrations in insulin-resistant first-degree relatives of patients with non-insulin-dependent diabetes mellitus: relationship to body composition and insulin sensitivity but not to family history of non-insulin-dependent diabetes mellitus
Nyholm, B., Fisker, S., Lund, S. A., Møller, N., & Schmitz, O. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1360173 · Cited by 44 · see citing works
Rapid Uptake and Binding of Estradiol-17β-6-(O-carboxymethyl)oxime:125I-labeled Bsa by Female Rat Liver1
Moats, R. K., & Ramirez, V. D. (1998) · Biology of Reproduction · doi:10.1095/biolreprod58.2.531 · Cited by 44 · see citing works
Expression of inducible nitric oxide synthase in macrophages and smooth muscle cells in various types of human atherosclerotic lesions
Luoma, J. S., & Ylä‐Herttuala, S. (1999) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280050384 · Cited by 43 · see citing works

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Oxidative Stress, Prooxidants, and Antioxidants: The Interplay
Rahal, A., Kumar, A., Singh, V., Yadav, B., Tiwari, R., Chakraborty, S., & Dhama, K. (2014) · BioMed Research International · doi:10.1155/2014/761264 · Cited by 1,730 · see citing works
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Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683 · see citing works
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Li, X., Fang, P., Mai, J., Choi, E. T., Wang, H., & Yang, X. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-19 · Cited by 810 · see citing works
Endothelial dysfunction — A major mediator of diabetic vascular disease
Sena, C. M., Pereira, A. M., & Seiça, R. M. F. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.08.006 · Cited by 796 · see citing works
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Madamanchi, N. R., & Runge, M. S. (2007) · Circulation Research · doi:10.1161/01.res.0000258450.44413.96 · Cited by 794 · see citing works
Cross talk between mitochondria and NADPH oxidases
Dikalov, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.033 · Cited by 783 · see citing works
Therapeutic Targeting of Mitochondrial Superoxide in Hypertension
Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 737 · see citing works
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Ďuračková, Z. (2010) · Physiological Research · doi:10.33549/physiolres.931844 · Cited by 718 · see citing works
Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction
Doughan, A. K., Harrison, D. G., & Dikalov, S. I. (2008) · Circulation Research · doi:10.1161/circresaha.107.162800 · Cited by 710 · see citing works
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Meyer, J. N., Leung, M. C. K., Rooney, J. P., Sendoel, A., Hengartner, M. O., Kisby, G. E., & Bess, A. S. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft102 · Cited by 571 · see citing works
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Melber, A., & Haynes, C. M. (2018) · Cell Research · doi:10.1038/cr.2018.16 · Cited by 488 · see citing works
Assessing bioenergetic function in response to oxidative stress by metabolic profiling
Dranka, B. P., Benavides, G. A., Diers, A. R., Giordano, S., Zelickson, B. R., Reily, C., Zou, L., Chatham, J. C., Hill, B. G., Zhang, J., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.005 · Cited by 436 · see citing works
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Zhang, D. X., & Gutterman, D. D. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01283.2006 · Cited by 432 · see citing works
Intercellular mitochondrial transfer as a means of tissue revitalization
Liu, D., Gao, Y., Liu, J., Huang, Y., Yin, J., Feng, Y., Shi, L., Meloni, B. P., Zhang, C., Zheng, M., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00440-z · Cited by 403 · see citing works
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Li, Z., Hulderman, T., Salmen, R., Chapman, R. S., Leonard, S. S., Young, S., Shvedova, A. A., Luster, M. I., & Simeonova, P. P. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9688 · Cited by 413 · see citing works
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Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 438 · see citing works
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Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383 · see citing works
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Self-citation
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Olmez, I., & Özyurt, H. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.11.009 · Cited by 301 · see citing works
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DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome
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Lima, C. F., Fernandes‐Ferreira, M., & Pereira‐Wilson, C. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.06.042 · Cited by 231 · see citing works
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Role of mitochondrial oxidative stress in hypertension
Dikalov, S., & Ungvari, Z. I. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00089.2013 · Cited by 202 · see citing works
NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species
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The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice
Mercer, J. R., Yu, E., Figg, N. L., Cheng, K., Prime, T. A., Griffin, J. L., Masoodi, M., Vidal‐Puig, A., Murphy, M. P., & Bennett, M. R. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.026 · Cited by 188 · see citing works
The Vitamin A–Redox Hypothesis: A Biochemical Basis for Honest Signaling via Carotenoid Pigmentation
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Hydrogen Peroxide
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Analysis of mitochondrial function using phosphorescent oxygen-sensitive probes
Will, Y., Hynes, J., Ogurtsov, V. I., & Papkovsky, D. B. (2006) · Nature Protocols · doi:10.1038/nprot.2006.351 · Cited by 173 · see citing works
Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays
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Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart
Gupte, S. A., Levine, R. J., Gupte, R. S., Young, M. E., Lionetti, V., Labinskyy, V., Floyd, B. C., Ojaimi, C., Bellomo, M., Wolin, M. S., et al. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.05.003 · Cited by 162 · see citing works
Targeted nanoparticles in mitochondrial medicine
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Long-Term Inhalation Exposure to Nickel Nanoparticles Exacerbated Atherosclerosis in a Susceptible Mouse Model
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Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes
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Nanotechnology inspired tools for mitochondrial dysfunction related diseases
Wen, R. M., Banik, B., Pathak, R., Kumar, A., Kolishetti, N., & Dhar, S. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.024 · Cited by 130 · see citing works
Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease
Xia, T. (2006) · Frontiers in bioscience · doi:10.2741/2142 · Cited by 130 · see citing works
Mitochondrial Pathophysiology, Reactive Oxygen Species, and Cardiovascular Diseases
Gao, L., Laude, K. M., & Cai, H. “. (2008) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2007.10.004 · Cited by 125 · see citing works
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Elks, C. M., Mariappan, N., Haque, M., Guggilam, A., Majid, D. S. A., & Francis, J. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90628.2008 · Cited by 123 · see citing works
Oxidative Stress and Growth-Regulating Intracellular Signaling Pathways in Cardiac Myocytes
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Christen, F., Desrosiers, V., Cyr, B.-A. D., Vandenberg, G. W., François, N. R. L., Tardif, J., Dufresne, F., Lamarre, S. G., & Blier, P. U. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.037 · Cited by 116 · see citing works
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Hobbs, D. A., George, T. W., & Lovegrove, J. A. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000188 · Cited by 114 · see citing works
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Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the American Society for Preventive Cardiology Part I: Bioenergetics, contemporary physical activity recommendations, benefits, risks, extreme exercise regimens, potential maladaptations
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Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells
Bahnson, E. M., Brasch, N. E., & Yun, J. S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.034 · Cited by 107 · see citing works
Identification of Pathways for Atherosclerosis in Mice
Wang, S. S., Schadt, E. E., Wang, H., Wang, X., Ingram-Drake, L. A., Shi, W., Drake, T. A., & Lusis, A. J. (2007) · Circulation Research · doi:10.1161/circresaha.107.152975 · Cited by 107 · see citing works
Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress
de Oliveira, J., Hort, M. A., Moreira, E. L. G., Glaser, V., Ribeiro‐do‐Valle, R. M., Prediger, R. D., Farina, M., Latini, A., & Bem, A. F. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.009 · Cited by 104 · see citing works
Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model
Zang, Q. S., Sadek, H. A., Maass, D. L., Martinez, B., Ma, L., Kilgore, J. A., Williams, N. S., Frantz, D. E., Wigginton, J. G., Nwariaku, F. E., et al. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00203.2011 · Cited by 103 · see citing works
Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels
Heinen, A., Aldakkak, M., Stowe, D. F., Rhodes, S. S., Riess, M. L., Varadarajan, S. G., & Camara, A. K. S. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00198.2007 · Cited by 103 · see citing works
Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice
Mauray, A., Felgines, C., Morand, C., Mazur, A., Scalbert, A., & Milenković, D. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.04.011 · Cited by 103 · see citing works
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Intihar, T. A., Martinez, E. A., & Gómez‐Pastor, R. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00103 · Cited by 102 · see citing works
Mitochondrial miR-762 regulates apoptosis and myocardial infarction by impairing ND2
Yan, K., An, T., Zhai, M., Huang, Y. H., Wang, Q., Wang, Y., Zhang, R., Wang, T., Liu, J., Zhang, Y., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1734-7 · Cited by 102 · see citing works
Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs
de Oliveira, M. R., Jardim, F. R., Setzer, W. N., Nabavi, S. M., & Nabavi, S. F. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.04.004 · Cited by 100 · see citing works
Mitochondria as a possible target for nicotine action
Malińska, D., Wieckowski, M. R., Michalska, B., Drabik, K., Prill, M., Patalas‐Krawczyk, P., Walczak, J., Szymański, J., Mathis, C., van der Toorn, M., et al. (2019) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-019-09800-z · Cited by 103 · see citing works
Signaling pathway networks mined from human pituitary adenoma proteomics data
Zhan, X., & Desiderio, D. M. (2010) · BMC Medical Genomics · doi:10.1186/1755-8794-3-13 · Cited by 100 · see citing works
Physical activity and COVID-19. The basis for an efficient intervention in times of COVID-19 pandemic
Clemente‐Suárez, V. J., Beltrán-Velasco, A. I., Ramos‐Campo, D. J., Mielgo‐Ayuso, J., Nikolaidis, P. Τ., Belando‐Pedreño, N., & Tornero-Aguilera, J. F. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113667 · Cited by 98 · see citing works
Mitochondrial Protein Quality Control: The Mechanisms Guarding Mitochondrial Health
Bohovych, I., Chan, S. S. L., & Khalimonchuk, O. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6199 · Cited by 96 · see citing works
Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease
Ushio‐Fukai, M., Ash, D., Nagarkoti, S., de Chantemèle, E. J. B., Fulton, D. J., & Fukai, T. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8161 · Cited by 96 · see citing works
Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease
Ait‐Aissa, K., Blaszak, S. C., Beutner, G., Tsaih, S., Morgan, G., Santos, J. H., Flister, M. J., Joyce, D. L., Camara, A. K. S., Gutterman, D. D., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43761-y · Cited by 94 · see citing works
Mitochondrial oxidative phosphorylation and energetic status are reflected by morphology of mitochondrial network in INS-1E and HEP-G2 cells viewed by 4Pi microscopy
Plecitá‐Hlavatá, L., Lessard, M. D., Šantorová, J., Bewersdorf, J., & Ježek, P. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.04.002 · Cited by 94 · see citing works
Mitochondrial function and energy metabolism in cancer cells: Past overview and future perspectives
Mayevsky, A. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.01.009 · Cited by 89 · see citing works
Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart
Pham, T., Loiselle, D. S., Power, A., & Hickey, A. J. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00006.2014 · Cited by 89 · see citing works
Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium
Zinovkin, R. A., Romaschenko, V. P., Galkin, I. I., Zakharova, V., Pletjushkina, O. Y., Chernyak, B. V., & Popova, E. N. (2014) · Aging · doi:10.18632/aging.100685 · Cited by 89 · see citing works
Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology
Little, M. P., Azizova, T. V., & Hamada, N. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1876955 · Cited by 88 · see citing works
Targeting Antioxidants to Mitochondria: A Potential New Therapeutic Strategy for Cardiovascular Diseases
Víctor, V. M., & Rocha, M. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780363077 · Cited by 85 · see citing works
Mitochondrial function in vascular endothelial cell in diabetes
Pangare, M., & Makino, A. (2012) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.48.1 · Cited by 83 · see citing works
Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: Predictive tests and biomarkers
Simeonova, P. P., & Erdely, A. (2009) · Inhalation Toxicology · doi:10.1080/08958370902942566 · Cited by 84 · see citing works
Zearalenone induces ROS‐mediated mitochondrial damage in porcine IPEC‐J2 cells
Fan, W., Shen, T., Ding, Q., Lv, Y., Li, L., Huang, K., Yan, L., & Song, S. (2017) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21944 · Cited by 83 · see citing works
Mitochondrial Function and Dysfunction: An Update
Davis, R. E., & Williams, M. J. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192104 · Cited by 83 · see citing works
The mitochondrial multi-omic response to exercise training across rat tissues
Amar, D., Gay, N. R., Jimenez‐Morales, D., Beltran, P. M. J., Ramaker, M. E., Raja, A. N., Zhao, B., Sun, Y., Marwaha, S., Gaul, D. A., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.021 · Cited by 81 · see citing works
Adipocyte Fatty Acid-Binding Protein Promotes Palmitate-Induced Mitochondrial Dysfunction and Apoptosis in Macrophages
Li, H., Xiao, Y., Tang, L., Zhong, F., Huang, G., Xu, J., Xu, A., Dai, R.-P., & Zhou, Z. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00081 · Cited by 80 · see citing works
Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages
Vijay, V., Han, T., Moland, C. L., Kwekel, J. C., Fuscoe, J. C., & Desai, V. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117047 · Cited by 80 · see citing works
Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Vivian, C. J., Brinker, A. E., Graw, S., Koestler, D. C., Legendre, C., Gooden, G. C., Salhia, B., & Welch, D. R. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1473 · Cited by 79 · see citing works
Exercise-Mediated Wall Shear Stress Increases Mitochondrial Biogenesis in Vascular Endothelium
Kim, B., Lee, H., Kawata, K., & Park, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111409 · Cited by 77 · see citing works
Role of oxidative stress in alterations of mitochondrial function in ischemic-reperfused hearts
Makazan, Z., Saini, H. K., & Dhalla, N. S. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01214.2006 · Cited by 76 · see citing works
Efficiency of mitochondrial functioning as the fundamental biological mechanism of general intelligence (g).
Geary, D. C. (2018) · Psychological Review · doi:10.1037/rev0000124 · Cited by 78 · see citing works
oxLDL induces injury and defenestration of human liver sinusoidal endothelial cells via LOX1
Zhang, Q., Liu, J., Liu, J., Huang, W., Tian, L., Quan, J., Wang, Y., & Niu, R. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0049 · Cited by 77 · see citing works
Near-infrared assessments of skeletal muscle oxidative capacity in persons with spinal cord injury
Erickson, M. L., RYAN, T. E., Young, H., & McCully, K. K. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2657-0 · Cited by 75 · see citing works
Antioxidant-based therapies for angiotensin II-associated cardiovascular diseases
Rosenbaugh, E. G., Savalia, K. K., Manickam, D. S., & Zimmerman, M. C. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00395.2012 · Cited by 74 · see citing works
New Perspectives on the Importance of Cell-Free DNA Biology
Bronkhorst, A. J., Ungerer, V., Oberhofer, A., Gabriel, S., Polatoglou, E., Randeu, H., Uhlig, C., Pfister, H., Mayer, Z., & Holdenrieder, S. (2022) · Diagnostics · doi:10.3390/diagnostics12092147 · Cited by 77 · see citing works
Oxidative stress and mitochondrial failure in the pathogenesis of glaucoma neurodegeneration
Pinazo-Duran, M. D., Zanón‐Moreno, V., Gallego‐Pinazo, R., & García‐Medina, J. J. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.06.001 · Cited by 75 · see citing works
Modulation of the renin–angiotensin–aldosterone system in sepsis: a new therapeutic approach?
Salgado, D. R., Rocco, J. R., Silva, E., & Vincent, J. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903460332 · Cited by 74 · see citing works
Lycopene Attenuates Tulathromycin and Diclofenac Sodium-Induced Cardiotoxicity in Mice
Abdel‐Daim, M. M., Eltaysh, R., Hassan, A. M., & Mousa, S. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020344 · Cited by 73 · see citing works
Mitochondrial reactive oxygen species and calcium uptake regulate activation of phagocytic NADPH oxidase
Dikalov, S., Li, W., Doughan, A. K., Blanco, R. R., & Zafari, A. M. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00842.2010 · Cited by 73 · see citing works
Mitochondria
Eirin, A., Lerman, A., & Lerman, L. O. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04598 · Cited by 70 · see citing works
Mitochondrial unfolded protein-related responses across kingdoms: similar problems, different regulators
Tran, H. C., & Aken, O. V. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.05.009 · Cited by 69 · see citing works

Deregulation of Mitochondrial Function: A Potential Common Theme for Cardiovascular Disease Development
Ballinger, S. W. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-420-9_10 · Cited by 3 · see citing works
Self-citation
Oxidative Stress and Cardiovascular Diseases: The Role of Mitochondria
Ghorbel, I., Chaâbane, M., Elwej, A., Ghorbel‐Koubaa, F., & Zeghal, N. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.103979 · Cited by 1 · see citing works
Mitochondrial Dysfunction as an Initiating Event in Atherogenesis: A Plausible Hypothesis
Puddu, P., Puddu, G. M., Galletti, L., Cravero, E., & Muscari, A. (2005) · Cardiology · doi:10.1159/000083440 · Cited by 87 · see citing works
The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis
Puddu, P., Puddu, G. M., Cravero, E., Pascalis, S. D., & Muscari, A. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-112 · Cited by 65 · see citing works
Regulatory role of mitochondria in oxidative stress and atherosclerosis
Chang, J. (2010) · World Journal of Cardiology · doi:10.4330/wjc.v2.i6.150 · Cited by 69 · see citing works

Authors: Ballinger, S. W.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Ballinger, Scott W.
ORCID: Ballinger, Scott W.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2005-05
Volume: 38
Issue: 10
Pages: 1278-1295
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2005.02.014
OpenAlex: W2005139390
Cited by: 405
References: 222
Citations by year: 2026: 8 · 2025: 16 · 2024: 21 · 2023: 18 · 2022: 19 · 2021: 27 · 2020: 20 · 2019: 16 · 2018: 17 · 2017: 24 · 2016: 20 · 2015: 22 · 2014: 28 · 2013: 29 · 2012: 25
FWCI: 1.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL 77419, R01HL077419)
National Institute of Environmental Health Sciences (ES11172, R01ES011172)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords: mitochondrial dysfunction, mitochondrial damage, cardiovascular disease, atherosclerosis, oxidative stress, cardiovascular risk factors
MeSH terms: Animals, Cardiovascular Diseases, Humans, Mitochondria, Heart, Reactive Oxygen Species, Oxidative Stress

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