Adiponectin, Leptin, and Resistin and the Risk of Dementia
Open accessAbstract
Background: Adipokines are hormones secreted by adipose tissue with roles in energy homeostasis and regulation of metabolism. Their dysregulation is suggested to contribute to the increased risk of dementia seen with midlife obesity, but longitudinal studies investigating this are scarce. We determined the association between plasma levels of adiponectin, leptin, and resistin with the risk of dementia. Methods: We performed a case–cohort study embedded in the prospective, population-based Rotterdam Study. Plasma levels of the adiponectin, leptin, and resistin were measured at baseline (1997–1999) in a random subcohort of 945 participants without dementia, and additionally in 177 participants, who were diagnosed with dementia during follow-up (until January 1, 2018). Results: Higher levels of leptin and resistin were associated with a decreased risk of dementia (adjusted hazard ratio [95% confidence interval] per SD increase of log-transformed values: 0.85 [0.72–1.00] for leptin; 0.82 [0.71–0.95] for resistin). The association of leptin with dementia was further modified by body mass index and by APOE ε4 carrier status. Adiponectin levels were not associated with the risk of dementia. Conclusions: These findings support the hypothesis that adipokines have a role in the pathophysiology of dementia. Future studies are warranted to confirm the findings and to explore the underlying mechanisms.
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Individuals with higher leptin levels are associated with a reduced risk of dementia and Alzheimer's disease.
“individuals with higher leptin levels are associated with a reduced risk of dementia and AD.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [586]
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
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- Authors
- Mooldijk, S. S., Ikram, M. K., & Ikram, M. A.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Ikram, Mohammad Arfan
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-09-15
- Volume
- 77
- Issue
- 6
- Pages
- 1245-1249
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC9159665
- OpenAlex
- W3199941868
- Cited by
- 44
- References
- 24
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 13 · 2023: 9 · 2022: 7
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journals of Gerontology Series A (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by-nc)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by-nc)
- Funders
- Ministry for Health, Welfare and Sports
- European Commission
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- adiponectin, leptin, resistin, adipokines, dementia risk, midlife obesity, body mass index, APOE ε4, dementia pathophysiology, Rotterdam Study
- MeSH terms
- Dementia, Humans, Prospective Studies, Cohort Studies, Leptin, Adiponectin, Resistin, Adipokines
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