Energetics of aging and frailty: the FRADEA study
Open accessAbstract
BACKGROUND: Resting metabolic rate (RMR) and total daily energy expenditure (TDEE) decrease with aging, but it is not known whether frailty modulates this association. We hypothesize that RMR and TDEE values are similar between younger and older nonfrail older adults, whereas they are lower in older prefrail and frail compared with younger adults. METHODS: A cross-sectional analysis of the FRADEA study, Albacete (Spain), including 402 participants (213 women) older than 70 years (mean age 76 years; range 70-91), was conducted. Estimated RMR (eRMR), oxygen consumption (VO2), expired volume (Ve), and respiratory frequency (RF) were determined using indirect calorimetry; TDEE was determined with the Calcumed instrument; and fat-free mass was determined by bioimpedanciometry. General linear models were used for analysis. RESULTS: Mean TDEE was 1,889 (SD 470) kcal and eRMR was 1,071 (SD 323) kcal. Both TDEE (B = -24 kcal/day; 95% confidence interval: -35.4 to -14.2; p < .001) and eRMR (B= -15.8 kcal/day; 95% confidence interval: -23.1 to -8.5; p < .001) diminished linearly with age, with lower values in frail and prefrail participants. There was a strong trend between frailty and lower eRMR (F = 2.9; p = .058), with a modifying effect between age and frailty (F = 3.6; p = .002). eRMR in prefrail and frail participants were on average 160 and 114 kcal/day less than that in the nonfrail participants, respectively, and taken together, 154 kcal/day less (F = 5.4; p = .020). Frail and prefrail participants also presented lower Ve and VO2 values that were partially compensated by an RF increase. CONCLUSION: Frailty status modulates the energy requirements of aging. Frail and prefrail older adults present lower eRMR than nonfrail adults.
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Reduced resting metabolic rate, physical activity, mitochondrial volume, and oxidative capacity with age contribute to aging-related decreases in muscle mass and strength.
“Reduced resting metabolic rate, physical activity, mitochondrial volume, and oxidative capacity with age contribute to aging-related decreases in muscle mass and strength (122–124).”
From Health Consequences of Sarcopenic Obesity: A Narrative Review (2020) · cites this paper as [122]
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- Authors
- Abizanda, P., Romero, L., Sánchez-Jurado, P. M., Ruano, T. F., Ríos, S. S., & Sánchez, M. F.
- Affiliations
- Complejo Hospitalario Universitario de Albacete (ES)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-10-13
- Volume
- 71
- Issue
- 6
- Pages
- 787-796
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC4888388
- OpenAlex
- W2221594233
- Cited by
- 44
- References
- 35
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Instituto de Salud Carlos III
- Rocky Mountain Research Station
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- frailty, pre-frailty, aging, resting metabolic rate, total energy expenditure, energy requirements, older adults, oxygen consumption, expired volume, respiratory rate, fat-free mass
- MeSH terms
- Aged, Aged, 80 and over, Aging, Basal Metabolism, Calorimetry, Indirect, Cross-Sectional Studies, Energy Metabolism, Female, Humans, Male, Oxygen Consumption, Spain, Geriatric Assessment, Frail Elderly
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