Adipose tissue inflammation in aging

Obesity is associated with macrophage accumulation in adipose tissue

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The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works

Prevalence and Trends in Obesity Among US Adults, 1999-2008

Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580 · see citing works

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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The M1 and M2 paradigm of macrophage activation: Time for reassessment

Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689 · see citing works

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844 · see citing works

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 2× · see citing works

Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061 · see citing works

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works

Geroscience: Linking Aging to Chronic Disease

Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764 · see citing works

The role of senescent cells in ageing

van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works

Inflammation, metaflammation and immunometabolic disorders

Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570 · see citing works

A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · cited 3× · see citing works

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230 · see citing works

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561 · see citing works

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-González, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., & Locksley, R. M. (2011) · Science · doi:10.1126/science.1201475 · Cited by 1,361 · see citing works

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,348 · see citing works

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.011 · Cited by 1,275 · cited 1× · see citing works

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

Winer, D. A., Winer, S., Shen, L., Wadia, P. P., Yantha, J., Paltser, G., Tsui, H., Wu, P., Davidson, M. G., Alonso, M. N., et al. (2011) · Nature Medicine · doi:10.1038/nm.2353 · Cited by 1,050 · see citing works

Quantitative assessment on the cloning efficiencies of lentiviral transfer vectors with a unique clone site

Zhang, G., & Tandon, A. (2012) · Scientific Reports · doi:10.1038/srep00415 · Cited by 1,039 · see citing works

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035 · see citing works

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 942 · see citing works

Inflammatory mediators in the elderly

Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

Lumeng, C. N.-K., DelProposto, J. B., Westcott, D. J., & Saltiel, A. R. (2008) · Diabetes · doi:10.2337/db08-0872 · Cited by 919 · see citing works

Ceramides in insulin resistance and lipotoxicity

Summers, S. A. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.11.002 · Cited by 852 · see citing works

Bypass of Senescence After Disruption of p21 ^{<i>CIP1/WAF1</i>} Gene in Normal Diploid Human Fibroblasts

Brown, J. P., Wei, W., & Sedivy, J. M. (1997) · Science · doi:10.1126/science.277.5327.831 · Cited by 804 · see citing works

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

Liu, J., Divoux, A., Sun, J., Zhang, J., Clément, K., Glickman, J. N., Sukhova, G. K., Wolters, P. J., Du, J., Gorgun, C. Z., et al. (2009) · Nature Medicine · doi:10.1038/nm.1994 · Cited by 796 · see citing works

Age-related changes in total and regional fat distribution

Kuk, J. L., Saunders, T. J., Davidson, L. E., & Ross, R. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.06.001 · Cited by 778 · see citing works

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

Murano, I., Barbatelli, G., Parisani, V., Latini, C., Muzzonigro, G., Castellucci, M., & Cinti, S. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800019-jlr200 · Cited by 726 · see citing works

The effect of sex, age and race on estimating percentage body fat from body mass index: The Heritage Family Study

Jackson, A., Stanforth, P., Gagnon, J., Rankinen, T., Leon, A., Rao, D., Skinner, J., Bouchard, C., & Wilmore, J. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802006 · Cited by 694 · see citing works

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

Felice, F. G. D., & Ferreira, S. T. (2014) · Diabetes · doi:10.2337/db13-1954 · Cited by 647 · see citing works

Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body

Giannakou, M. E., Goss, M. W., Jünger, M. A., Hafen, E., Leevers, S. J., & Partridge, L. (2004) · Science · doi:10.1126/science.1098219 · Cited by 577 · see citing works

Obesity Paradox Does Exist

Hainer, V., & Aldhoon-Hainerová, I. (2013) · Diabetes Care · doi:10.2337/dcs13-2023 · Cited by 503 · see citing works

Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance

Yang, H., Youm, Y., Vandanmagsar, B., Ravussin, A., Gimble, J. M., Greenway, F. L., Stephens, J. M., Mynatt, R. L., & Dixit, V. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000021 · Cited by 441 · see citing works

JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes

Nguyen, M. T. A., Satoh, H., Favelyukis, S., Babendure, J. L., Imamura, T., Sbodio, J. I., Zalevsky, J., Dahiyat, B. I., Chi, N.-W., & Olefsky, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504611200 · Cited by 411 · see citing works

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

Kawasaki, N., Asada, R., Saito, A., Kanemoto, S., & Imaizumi, K. (2012) · Scientific Reports · doi:10.1038/srep00799 · Cited by 404 · see citing works

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

Furman, D., Chang, J., Lartigue, L., Bolen, C. R., Haddad, F., Gaudilliere, B., Ganio, E. A., Fragiadakis, G. K., Spitzer, M. H., Douchet, I., et al. (2017) · Nature Medicine · doi:10.1038/nm.4267 · Cited by 389 · cited 1× · see citing works

The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity

Shan, B., Wang, X., Wu, Y., Xu, C., Xia, Z., Dai, J., Shao, M., Zhao, F., He, S., Yang, L., et al. (2017) · Nature Immunology · doi:10.1038/ni.3709 · Cited by 367 · see citing works

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

Arai, Y., Martin-Ruiz, C. M., Takayama, M., Abe, Y., Takebayashi, T., Koyasu, S., Suematsu, M., Hirose, N., & von Zglinicki, T. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.07.029 · Cited by 333 · see citing works

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

Lumeng, C. N., Liu, J., Geletka, L., Delaney, C., Delproposto, J., Desai, A., Oatmen, K., Martinez-Santibanez, G., Julius, A., Garg, S., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102188 · Cited by 328 · see citing works

Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence

Adams, P. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.021 · Cited by 326 · see citing works

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

Bapat, S. P., Suh, J. M., Fang, S., Liu, S., Zhang, K. Y., Cheng, A., Zhou, C., Liang, Y., Leblanc, M., Liddle, C., et al. (2015) · Nature · doi:10.1038/nature16151 · Cited by 325 · see citing works

Aging and adipose tissue: potential interventions for diabetes and regenerative medicine

Palmer, A. K., & Kirkland, J. L. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.013 · Cited by 313 · see citing works

Role for CD4+ CD25+ Regulatory T Cells in Reactivation of Persistent Leishmaniasis and Control of Concomitant Immunity

Méndez, S., Reckling, S. K., Piccirillo, C. A., Sacks, D. L., & Belkaid, Y. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040298 · Cited by 296 · see citing works

Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue

Wu, D., Ren, Z., Pae, M., Guo, W., Cui, X., Merrill, A. H., & Meydani, S. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4829 · Cited by 288 · see citing works

Inflammatory lipid mediators in adipocyte function and obesity

Iyer, A., Fairlie, D. P., Prins, J. B., Hammock, B. D., & Brown, L. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.264 · Cited by 284 · see citing works

Healthy obese versus unhealthy lean: the obesity paradox

Lavie, C. J., De Schutter, A., & Milani, R. V. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.165 · Cited by 266 · see citing works

Connecting obesity, aging and diabetes

Ahima, R. S. (2009) · Nature Medicine · doi:10.1038/nm0909-996 · Cited by 264 · see citing works

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

Blüher, M. (2016) · Clinical Science · doi:10.1042/cs20160005 · Cited by 262 · see citing works

High Accumulation of T Regulatory Cells Prevents the Activation of Immune Responses in Aged Animals

Sharma, S., Dominguez, A. L., & Lustgarten, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8348 · Cited by 240 · see citing works

The role of inflammation in age-related disease

Howcroft, T. K., Campisi, J., Louis, G. B., Smith, M. T., Wise, B., Wyss-Coray, T., Augustine, A. D., McElhaney, J. E., Kohanski, R., & Sierra, F. (2013) · Aging · doi:10.18632/aging.100531 · Cited by 239 · see citing works

Oxidative Stress, Inflammaging, and Immunosenescence

Bauer, M. E., & la Fuente, M. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00004-6 · Cited by 229 · see citing works

Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes

Yaghootkar, H., Scott, R. A., White, C. C., Zhang, W., Speliotes, E. K., Munroe, P. B., Ehret, G., Bis, J. C., Fox, C. S., Walker, M., et al. (2014) · Diabetes · doi:10.2337/db14-0318 · Cited by 218 · see citing works

Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

Salvioli, S., Monti, D., Lanzarini, C., Conte, M., Pirazzini, C., Bacalini, M. G., Garagnani, P., Giuliani, C., Fontanesi, E., Ostan, R., et al. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219531 · Cited by 208 · see citing works

Aging is associated with increased regulatory T ‐cell function

Garg, S. K., Delaney, C. E., Toubai, T., Ghosh, A. K., Reddy, P. R., Banerjee, R. V., & Yung, R. L. (2013) · Aging Cell · doi:10.1111/acel.12191 · Cited by 184 · see citing works

Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies

Gire, V., & Wynford-Thomas, D. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1611 · Cited by 161 · see citing works

Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice

Zamarron, B. F., Mergian, T. A., Cho, K. W., Martinez-Santibañez, G., Luan, D., Singer, K., DelProposto, J. L., Geletka, L. M., Muir, L. A., & Lumeng, C. N.-K. (2016) · Diabetes · doi:10.2337/db16-0500 · Cited by 159 · see citing works

Epithelial adhesive junctions

Capaldo, C., Farkas, A. E., & Nusrat, A. (2014) · F1000Prime Reports · doi:10.12703/p6-1 · Cited by 149 · see citing works

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

Stout, M. B., Tchkonia, T., Pirtskhalava, T., Palmer, A. K., List, E. O., Berryman, D. E., Lubbers, E. R., Escande, C., Spong, A., Masternak, M. M., et al. (2014) · Aging · doi:10.18632/aging.100681 · Cited by 136 · see citing works

The Multifaceted Roles of Adipose Tissue—Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture

Scherer, P. E. (2016) · Diabetes · doi:10.2337/db16-0339 · Cited by 133 · cited 1× · see citing works

Fetuin-null mice are protected against obesity and insulin resistance associated with aging

Mathews, S. T., Rakhade, S. N., Zhou, X., Parker, G. C., Coscina, D. V., & Grunberger, G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.071 · Cited by 129 · see citing works

Adipose Tissue and Adipokines in Health and Disease

Morris, A. M., Poirier, P., & Eckle, R. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-370-7 · Cited by 126 · see citing works

ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity

Suzuki, T., Gao, J., Ishigaki, Y., Kondo, K., Sawada, S., Izumi, T., Uno, K., Kaneko, K., Tsukita, S., Takahashi, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.076 · Cited by 125 · see citing works

The aging gut microbiota: New perspectives

Biagi, E., Candela, M., Franceschi, C., & Brigidi, P. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.03.004 · Cited by 116 · see citing works

Receptor-mediated signaling pathways: potential targets of modulation by dietary fatty acids

Hwang, D., & Rhee, S. H. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.4.545 · Cited by 96 · see citing works

Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging

Ghosh, A. K., Garg, S. K., Mau, T., O’Brien, M., Liu, J., & Yung, R. L. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu186 · Cited by 96 · see citing works

Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

Salvioli, S., Monti, D., Lanzarini, C., et al. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319090015 · Cited by 95 · see citing works

Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue

Ghosh, A. K., Mau, T., O’Brien, M., Garg, S., & Yung, R. L. (2016) · Aging · doi:10.18632/aging.101083 · Cited by 88 · see citing works

Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity

Chen, Y., Wu, Z., Zhao, S., & Xiang, R. (2016) · Scientific Reports · doi:10.1038/srep27486 · Cited by 80 · see citing works

Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo

Park, E., Wong, V. S. C., Guan, X., Oprescu, A. I., & Giacca, A. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0005 · Cited by 75 · see citing works

Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging

Ghosh, A. K., O’Brien, M., Mau, T., & Yung, R. L. (2017) · Aging · doi:10.18632/aging.101288 · Cited by 58 · see citing works

Treating Neurodegenerative Diseases with Antibiotics

Miller, T. M., & Cleveland, D. W. (2005) · Science · doi:10.1126/science.1109027 · Cited by 52 · see citing works

Energetics of aging and frailty: the FRADEA study

Abizanda, P., Romero, L., Sánchez-Jurado, P. M., Ruano, T. F., Ríos, S. S., & Sánchez, M. F. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv182 · Cited by 44 · see citing works

Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo

Pereira, S., Park, E., Moore, J., Faubert, B., Breen, D. M., Oprescu, A. I., Nahle, A., Kwan, D., Giacca, A., & Tsiani, E. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0075 · Cited by 32 · see citing works

Adipose Tissue and Adipokines in Health and Disease

Fantuzzi, G., & Braunschweig, C. A. (2014) · Humana Press eBooks · doi:10.1007/978-1-62703-770-9 · Cited by 28 · see citing works

Response to Comment on "Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body"

Giannakou, M. E., Goss, M. W., Jünger, M. A., Hafen, E., Leevers, S. J., & Partridge, L. (2005) · Science · doi:10.1126/science.1104733 · Cited by 7 · see citing works

International exercise recommendations in older adults (ICFSR): Expert consensus guidelines

Izquierdo, M., Merchant, R. A., Morley, J. E., Anker, S. D., Aprahamian, I., Arai, H., Aubertin-Leheudre, M., Bernabei, R., Cadore, E. L., Cesari, M., et al. (2021) · The Journal of nutrition, health and aging · doi:10.1007/s12603-021-1665-8 · Cited by 1,247 · see citing works

The integration of inflammaging in age-related diseases

Fülöp, T., Witkowski, J. M., Olivieri, F., & Larbi, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.003 · Cited by 356 · see citing works

The impact of aging on adipose function and adipokine synthesis

Mancuso, P., & Bouchard, B. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00137 · Cited by 314 · see citing works

Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)

Izquierdo, M., de Souto Barreto, P., Arai, H., Bischoff-Ferrari, H. A., Cadore, E. L., Cesari, M., Chen, L.-K., Coen, P. M., Courneya, K. S., Duque, G., et al. (2025) · The Journal of nutrition, health and aging · doi:10.1016/j.jnha.2024.100401 · Cited by 273 · see citing works

White adipose tissue dysfunction in obesity and aging

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Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation

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Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview

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Interaction Among Sex, Aging, and Epigenetic Processes Concerning Visceral Fat, Insulin Resistance, and Dyslipidaemia

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T Cells in Adipose Tissue in Aging

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Adipose Tissue Aging and Metabolic Disorder, and the Impact of Nutritional Interventions

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Aging, Obesity, and the Incidence of Diverticulitis: A Population-Based Study

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How Inflammation Blunts Innate Immunity in Aging

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Endoplasmic Reticulum Stress and Its Impact on Adipogenesis: Molecular Mechanisms Implicated

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Inflammation and metabolism: the role of adiposity in sarcopenic obesity

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Adipose tissue macrophages in aging-associated adipose tissue function

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Sarcopenia, Obesity, Sarcopenic Obesity and Risk of Poor Nutritional Status in Polish Community-Dwelling Older People Aged 60 Years and Over

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Effect of Dietary Silk Peptide on Obesity, Hyperglycemia, and Skeletal Muscle Regeneration in High-Fat Diet-Fed Mice

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Phenotypic Changes in T Cell and Macrophage Subtypes in Perivascular Adipose Tissues Precede High-Fat Diet-Induced Hypertension

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Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration

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Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

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Adherence to Mediterranean Diet, Malnutrition, Length of Stay and Mortality in Elderly Patients Hospitalized in Internal Medicine Wards

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Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging

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Aging of Bone Marrow Mesenchymal Stromal Cells: Hematopoiesis Disturbances and Potential Role in the Development of Hematologic Cancers

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mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis

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Both ghrelin deletion and unacylated ghrelin overexpression preserve muscles in aging mice

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A Glimpse into Uveitis in the Aging Eye: Pathophysiology, Clinical Presentation and Treatment Considerations

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Helminth-derived biomacromolecules as therapeutic agents for treating inflammatory and infectious diseases: What lessons do we get from recent findings?

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Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging

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p16 INK4A drives nonalcoholic fatty liver disease phenotypes in high fat diet fed mice through biliary E2F1/FOXO1/IGF-1 signaling

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Physiological Approaches Targeting Cellular and Mitochondrial Pathways Underlying Adipose Organ Senescence

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Exercise reduces metabolic burden while altering the immune system in aged mice

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The impact of the senescent microenvironment on tumorigenesis: Insights for cancer therapy

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Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

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GHR−/− Mice are protected from obesity‐related white adipose tissue inflammation

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Lifestyle and Food Habits Impact on Chronic Diseases: Roles of PPARs

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High‐fat diet induced obesity and age influence the telomere shelterin complex and telomerase gene expression in mouse adipose tissue

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SARS-CoV-2 infection induces persistent adipose tissue damage in aged golden Syrian hamsters

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The “Iron Tale”- iron indices and handgrip strength in community-dwelling adults

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Different Effects of Low Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Function and Insulin Secretion in Adolescent Male Rats

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Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice

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Inhibition of p38mapk Reduces Adipose Tissue Inflammation in Aging Mediated by Arginase-II

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Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity

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Body Composition and Senescence: Impact of Polyphenols on Aging-Associated Events

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p38α Deficiency in T Cells Ameliorates Diet-Induced Obesity, Insulin Resistance, and Adipose Tissue Senescence

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Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification

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Associations of serum IL-6 with muscle, bone, and adipose tissue in women

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Triple threat: adiposity, aging, atrial fibrillation

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B-cell interleukin 1 receptor 1 modulates the female adipose tissue immune microenvironment during aging

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Impact of aging on gut-lung-adipose tissue interactions and lipid metabolism during influenza infection in mice

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Aging alone or combined with obesity increases white adipose tissue inflammatory status in male mice

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Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms

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Hubungan antara obesitas sentral dengan massa dan fungsi otot ekstremitas pada populasi lanjut usia di kawasan rural Provinsi Bali-Indonesia

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Age-related changes in adipose tissue metabolomics and inflammation, cardiolipin metabolism, and ferroptosis markers in female aged rat model

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The dynamic nature of ageing: novel findings, therapeutic avenues and medical interventions

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Association between A Body Shape Index and the Prevalence of Stroke: A Cross-Sectional Study

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Impact of time‐restricted feeding on metabolic health and adipose tissue metabolism in aged female mice with high‐fat diet‐induced obesity

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Inflammation-related indices and low physical performance in older adults with unintentional weight loss: a cross-sectional study

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Age-driven shifts in T and NK cell responses amplify inflammation and coagulopathy during viral infection in mice and humans

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Ultra-Processed Foods and Chronic Kidney Disease: Is Inflammaging the Missing Link?

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General Principles, Etiologies, Evaluation, and Management in Older Adults

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