Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging
Open accessAbstract
BACKGROUND/OBJECTIVES: Resilience, the ability to resist or recover from adverse effects of a stressor, is of widespread interest in social, psychologic, biologic, and medical research and particularly salient as the capacity to respond to stressors becomes diminished with aging. To date, research on human resilience responses to and factors influencing these responses has been limited. METHODS: The National Institute on Aging convened a workshop in August 2015 on needs for research to improve measures to predict and assess resilience in human aging. Effects of aging-related factors in impairing homeostatic responses were developed from examples illustrating multiple determinants of clinical resilience outcomes. Research directions were identified by workshop participants. RESULTS: Research needs identified included expanded uses of clinical data and specimens in predicting or assessing resilience, and contributions from epidemiological studies in identifying long-term predictors. Better measures, including simulation tests, are needed to assess resilience and its determinants. Mechanistic studies should include exploration of influences of biologic aging processes on human resiliencies. Important resource and infrastructure needs include consensus phenotype definitions of specific resiliencies, capacity to link epidemiological and clinical resilience data, sensor technology to capture responses to stressors, better laboratory animal models of human resiliencies, and new analytic methods to understand the effects of multiple determinants of stress responses. CONCLUSIONS: Extending the focus of care and research to improving the capacity to respond to stressors could benefit older adults in promoting a healthier life span.
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Interlinked fundamental aging processes appear to act as root causes of many disorders and diseases.
“Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [17]
The “Mechanistic Studies” section says basic aging mechanisms may act individually or collectively and influence a wide variety of aging-related outcomes. The “Influence of Biologic Aging Mechanisms on Resilience” section says they could contribute to declining clinical and physiologic resilience. Neither section establishes that these processes are root-cause contributors to many disorders and diseases; the paper frames their influence as a subject for further research. The supplied passages give no page numbers. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe Geroscience Hypothesis holds that the pillars of aging, including cellular senescence, tend to progress together and may be root-cause contributors to multiple diseases, age-related dysfunction, and loss of resilience.
“The Geroscience Hypothesis holds that these pillars of aging, including cellular senescence, tend to progress in concert and may be root-cause contributors to the pathophysiology of multiple diseases”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [17]
The “Influence of Biologic Aging Mechanisms on Resilience” section identifies cellular senescence as a mechanism that could affect several types of resilience, and “Mechanistic Studies” says aging mechanisms may influence a wide variety of outcomes. Our copy does not say that the pillars of aging progress in concert or establish them as root-cause contributors to multiple diseases. (LLM, conf=0.84)
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“Physiologic reserve is likely determined in part by comorbidities(11-13) and biological processes at the tissue, cellular, or subcellular level,(14) and it may bemanifest in the individual’s baseline functional status.(13) The magnitude and duration of the stressor could also affect the subsequent recovery pattern.”
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Physiological Systems in Promoting Frailty
Perazza, L. R., Brown‐Borg, H. M., & Thompson, L. V. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210034 · Cited by 64 · see citing works
Resilience and Intrinsic Capacity in Older Adults: A Review of Recent Literature
Grigoraș, G., Ilie, A. C., Turcu, A.-M., Albişteanu, S.-M., Lungu, I.-D., Ștefăniu, R., Pîslaru, A. I., Gavrilovici, O., & Alexa, I. D. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14217729 · Cited by 38 · see citing works
Identifying Characteristics of Frailty in Female Mice Using a Phenotype Assessment Tool
Kwak, D., Baumann, C. W., & Thompson, L. V. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz092 · Cited by 36 · see citing works
“Resilience is defined as the ability of an organism to respond to stress (29,30).”
BackgroundResilience integrates concepts in aging research
Promislow, D., Anderson, R. M., Scheffer, M., Crespi, B. J., DeGregori, J. V., Harris, K., Natterson-Horowitz, B., Levine, M. E., Riolo, M. A., Schneider, D. S., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104199 · Cited by 38 · see citing works
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Self-citationBiomarkers Associated with Physical Resilience After Hip Fracture
Parker, D., Colon-Emeric, C. S., Huebner, J. L., Chou, C., Kraus, V. B., Pieper, C. F., Sloane, R. J., Whitson, H. E., Orwig, D., Crabtree, D., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa119 · Cited by 34 · see citing works
Self-citationMeasuring Biologic Resilience in Older Cancer Survivors.
Sedrak, M., Gilmore, N., Carroll, J., Muss, H., Cohen, H. J., & Dale, W. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.21.00245 · Cited by 21 · see citing works
Resilience in older adults with cancer: A scoping literature review
George, T., Shah, F., Tiwari, A., Gutierrez, E., Ji, J., Kuchel, G. A., Cohen, H. J., & Sedrak, M. S. (2022) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2022.07.009 · Cited by 33 · see citing works
Self-citationA template for physical resilience research in older adults: Methods of the PRIME‐KNEE study
Whitson, H. E., Crabtree, D., Pieper, C. F., Ha, C., Au, S., Berger, M., Cohen, H. J., Feld, J., Smith, P. J., Hall, K. S. M., et al. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17384 · Cited by 33 · see citing works
Self-citationImpact of Standing Speed on the Peripheral and Central Hemodynamic Response to Orthostasis
O’Connor, J. D., O’Connell, M. D. L., Nolan, H., Newman, L., Knight, S. P., & Kenny, R. A. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.14040 · Cited by 31 · see citing works
“Recent interest in the development of protocols for measurement of dynamic physiological resilience introduces a challenge in standardization (ie, ensuring the stressor is physiologically equivalent for all demographics).(30,31) The data herein suggest that the physiological stressor posed by the active stand differs…”
BackgroundPhysical resilience in older adults: Potential use in promoting healthy aging
Li, J., Chhetri, J. K., & Ma, L. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101701 · Cited by 30 · see citing works
Rector, J. L., Gijzel, S. M. W., van de Leemput, I. A., van Meulen, F., Rikkert, M. G. M. O., & Melis, R. J. F. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111341 · Cited by 30 · see citing works
Rhythmic auditory stimuli modulate movement recovery in response to perturbation during locomotion
Ravi, D. K., Bartholet, M., Σκιαδόπουλος, Α., Kent, J. A., Wickstrom, J., Taylor, W. R., Singh, N. B., & Stergiou, N. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.237073 · Cited by 29 · see citing works
Intrinsic capacity and resilience: Taking frailty to the next level
Hamaker, M. E., Gijzel, S. M. W., Rostoft, S., et al. (2023) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2022.101421 · Cited by 29 · see citing works
Physiological Systems in Promoting Frailty
Perazza, L. R., Brown‐Borg, H. M., & Thompson, L. V. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00224.x · Cited by 30 · see citing works
“Resilience within the discussion of health is the ability to resist or recover from adverse events after an acute or chronic health stressor (Figure 1) (216, 573, 612, 613).”
Kolk, D., Melis, R. J. F., Vroomen, J. L. M., et al. (2021) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2021.08.029 · Cited by 29 · see citing works
Considering Frailty in SARS-CoV-2 Vaccine Development: How Geriatricians Can Assist
Andrew, M. K., Schmader, K. E., Rockwood, K. J., Clarke, B., & McElhaney, J. E. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s295522 · Cited by 28 · see citing works
Self-citationTaylor, M. G., Ureña, S., Carr, D., & Min, S. N. (2019) · The journals of gerontology. Series B, Psychological sciences and social sciences · doi:10.1093/geronb/gby029 · Cited by 23 · see citing works
Frailty and rheumatic diseases: evidence to date and lessons learned
Lieber, S. B., Wysham, K. D., Sattui, S. E., Yung, R. L., & Misra, D. (2024) · The Lancet Rheumatology · doi:10.1016/s2665-9913(24)00191-7 · Cited by 27 · see citing works
Self-citationThe aging bladder phenotype is not the direct consequence of bladder aging
Hardy, C. C., Keilich, S. R., Harrison, A. G., et al. (2019) · Neurourology and Urodynamics · doi:10.1002/nau.24149 · Cited by 27 · see citing works
“Resilience is the ability to adapt to multiple physiologic stressors.(15) Aging is associated with the loss of resilience, thus the increased prevalence of symptoms in the aged might be more accurately considered as the loss of an adaptive threshold across multiple domains intrinsic and extrinsic to urinary control.”
Goel, K., O’Leary, J., Barker, C. M., Levack, M. M., Rajagopal, V., Makkar, R., BAJWA, T. K., Kleiman, N. S., Linke, A. H.-P., Kereiakes, D. J., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.017075 · Cited by 25 · see citing works
“16,17 Specifically, we evaluated gait speed at baseline and 1 year after TAVR, the predictors of change in gait speed, and the associations with mortality and hospitalizations between 1 and 2 years.”
Wu, C., Kim, D. H., Xue, Q., Lee, D. S. H., Varadhan, R., & Odden, M. C. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly080 · Cited by 27 · see citing works
Self-citationAging-related Resiliency Theory Development
Feliciano, E. E., Feliciano, A., Palompon, D. R., & Boshra, A. (2021) · Belitung Nursing Journal · doi:10.33546/bnj.1631 · Cited by 25 · see citing works
Ageing and physical resilience after health stressors
Colon-Emeric, C. S., Schmader, K. E., Cohen, H. J., Morey, M. C., & Whitson, H. E. (2023) · Stress and Health · doi:10.1002/smi.3241 · Cited by 24 · see citing works
Self-citationCreating the Next Generation of Translational Geroscientists
Newman, J. C., Sokoloski, J. L., Robbins, P. D., Niedernhofer, L. J., Reed, M. J., Wei, J., Austad, S. N., Barzilai, N., Cohen, H. J., Kuchel, G. A., et al. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16055 · Cited by 24 · see citing works
“Geroscience clinical trials, as envisaged by the Geroscience Network retreats, would target integrative, multisystem phenotypes of aging, such as geriatric syndromes,(8) multimorbidity, or resilience to acute health stressors.(9) The pathophysiology being targeted is aging, not a particular disease.”
BackgroundSelf-citationPathways, Contributors, and Correlates of Functional Limitation Across Specialties: Workshop Summary
Kritchevsky, S. B., Forman, D. E., Callahan, K. E., Ely, E. W., High, K. P., McFarland, F., Pérez‐Stable, E. J., Schmader, K. E., Studenski, S. A., Williams, J. P., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly093 · Cited by 24 · see citing works
“As discussed at a 2015 National Institute on Aging workshop (23), a stressor such as an illness or accident causes functional decline from an initial level to a nadir, followed by some Journals of Gerontology: MEDICAL SCIENCES, 2019, Vol.”
BackgroundSelf-citationPredictive Validity of the Physical Resilience Instrument for Older Adults (PRIFOR)
Hu, F., Lin, C., Lin, C. H., et al. (2021) · The journal of nutrition health & aging · doi:10.1007/s12603-021-1667-6 · Cited by 22 · see citing works
Modelling physical resilience in ageing mice
Schosserer, M., Banks, G. T., Doğan, S., Dungel, P., Fernandes, A. M. A., Marolt, D., Matheu, A., Osuchowski, M. F., Potter, P. K., Sanfeliu, C., et al. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.10.001 · Cited by 19 · see citing works
“In our view, challenging ageing mice after administration of geroprotectors matches the clinical situation more closely than challenging young mice even if using harsher stressors as suggested by others (Hadley et al., 2017; Kirkland et al., 2016; LeBrasseur, 2017).”
BackgroundRikkert, M. G. M. O., & Melis, R. J. F. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00723 · Cited by 20 · see citing works
Coverage hole detection method of wireless sensor network based on clustering algorithm
Wang, F., & Hu, H. (2021) · Measurement · doi:10.1016/j.measurement.2021.109449 · Cited by 20 · see citing works
Risk Factors for Nonresilient Outcomes in Older Adults After Total Knee Replacement
Laskow, T. C., Zhu, J., Buta, B. J., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab257 · Cited by 18 · see citing works
Self-citationExercise for patients with chronic kidney disease: from cells to systems to function
Gollie, J. M., Ryan, A. S., Sen, S., Patel, S. S., Kokkinos, P. F., Harris‐Love, M. O., Scholten, J. D., & Blackman, M. R. (2024) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00302.2023 · Cited by 19 · see citing works
Development of a person-centered conceptual model of perceived fatigability
Kratz, A. L., Murphy, S. L., Braley, T. J., Basu, N., Kulkarni, S., Russell, J., & Carlozzi, N. E. (2019) · Quality of Life Research · doi:10.1007/s11136-018-2093-z · Cited by 18 · see citing works
The older adult surgical patient: a review of optimization and gaps in clinical practice
Canales, C., Wann, L., Blitz, J. D., & Whittington, R. A. (2025) · Perioperative Medicine · doi:10.1186/s13741-025-00593-x · Cited by 20 · see citing works
“For years, perioperative clinicians have been calling for routine preoperative assessment of older adults, focusing on cognitive changes, frailty, and nutrition (Chow et al. 2012; Oresanya et al. 2014; McIsaac et al. 2017; Berger et al. 2018; Hadley et al. 2017; Persico et al. 2018).”
Koivunen, K., Sillanpää, E., von Bonsdorff, M. B., Sakari‐Rantala, R., Törmäkangas, T., & Rantanen, T. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz251 · Cited by 17 · see citing works
Taylor, H. A., Washington-Plaskett, T., & Quyyumi, A. A. (2020) · Ethnicity & Disease · doi:10.18865/ed.30.2.365 · Cited by 17 · see citing works
Defining Resilience in Older People: Does a Subjective Definition of Stressor Work?
Pedone, C., Costanzo, L., Finamore, P., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa189 · Cited by 17 · see citing works
“Resilience has been increasingly recognized as a fundamental determinant of successful aging (4), and the National Institute of Aging indicates it as a priority research topic (5).”
BackgroundSelf-citationReitz, K. M., Seymour, C. W., Vates, J., Quintana, M., Viele, K., Detry, M. A., Morowitz, M. J., Morris, A., Methé, B. A., Kennedy, J. N., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-037690 · Cited by 17 · see citing works
Self-citationKatsiferis, A., Bhatt, S., Mortensen, L. H., Mishra, S., & Westendorp, R. G. J. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282892 · Cited by 16 · see citing works
Cesari, M., Azzolino, D., LeBrasseur, N. K., Whitson, H. E., Rooks, D., Sourdet, S., Angioni, D., Fielding, R. A., Vellas, B. J., Rolland, Y., et al. (2022) · The Journal of Frailty & Aging · doi:10.14283/jfa.2022.62 · Cited by 16 · see citing works
Self-citationFunction Begets Function and Resilience in Old Age: Is Precision Gerontology Possible?
Kuchel, G. A. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14901 · Cited by 16 · see citing works
Self-citationSenescence in the lung: is this getting old?
Morty, R. E., & Prakash, Y. S. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00081.2019 · Cited by 15 · see citing works
Farrell, S., Kane, A. E., Bisset, E. S., Howlett, S. E., & Rutenberg, A. D. (2022) · eLife · doi:10.7554/elife.77632 · Cited by 14 · see citing works
“Reduced resilience, or the decreasing ability to repair damage (or recover from stressors), is increasingly seen as a key manifestation of organismal aging (Ukraintseva et al., 2021; Kirkland et al., 2016; Hadley et al., 2017).”
BackgroundThe Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies
Nunkoo, V. S., Cristian, A., Jurcău, A., Diaconu, R. G., & Jurcău, M. C. (2024) · Biomedicines · doi:10.3390/biomedicines12112540 · Cited by 15 · see citing works
Hladek, M. D., Zhu, J., Crews, D. C., McAdams‐DeMarco, M., Buta, B. J., Varadhan, R., Shafi, T., Walston, J. D., & Bandeen‐Roche, K. (2022) · Kidney International Reports · doi:10.1016/j.ekir.2022.06.009 · Cited by 14 · see citing works
“One potential way to improve mortality risk assessment is through physical resilience measurement.(7,8)”
BackgroundSelf-citationSchaaf, G. W., Justice, J. N., Quillen, E. E., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00812-7 · Cited by 14 · see citing works
“Resilience is the dynamic property which enables cells, organs, and organisms to resist or recover from adverse effects of a stressor [13, 16–18].”
BackgroundMeasurement instruments for quantifying physical resilience in aging: a scoping review protocol
Peters, S., Cosco, T. D., Mackey, D. C., Sarohia, G. S., Leong, J., & Wister, A. (2019) · Systematic Reviews · doi:10.1186/s13643-019-0950-7 · Cited by 13 · see citing works
Social environment as a modulator of immunosenescence
Garrido, A., de Toda, I. M., Cerro, E. D., Félix, J., Ceprián, N., González-Sánchez, M., & la Fuente, M. D. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.24 · Cited by 13 · see citing works
Karlamangla, A. S., Almeida, D. M., Lachman, M. E., Merkin, S. S., Thomas, D., & Seeman, T. E. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105804 · Cited by 13 · see citing works
Using Physiological System Networks to Elaborate Resilience Across Frailty States
Hao, M., Zhang, H., Li, Y., Hu, X., Hu, Z., Jiang, X., Wang, J., Sun, X., Liu, Z., Davis, D., et al. (2024) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glad243 · Cited by 12 · see citing works
Vigor to Frailty As a Continuum—A New Approach in the Study of Muscle, Mobility, and Aging Cohort
Newman, A. B., BLACKWELL, T. L., Mau, T., Cawthon, P. M., Coen, P. M., Cummings, S. R., Toledo, F. G. S., Goodpaster, B. H., Glynn, N. W., Hepple, R. T., et al. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad244 · Cited by 12 · see citing works
Self-citationNewman, A. B., Kritchevsky, S. B., Guralnik, J. M., Cummings, S. R., Salive, M. E., Kuchel, G. A., Schrack, J. A., Morris, M. C., Weir, D. R., Baccarelli, A., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz230 · Cited by 12 · see citing works
“loss of these integrative functions with age, which may reveal changes in an individual long before loss of physical function is apparent, thus holding promise as early markers of aging (82, 83).”
BackgroundSelf-citationSkeletal muscle DNA methylation: Effects of exercise and HIV
Jankowski, C. M., Konigsberg, I. R., Wilson, M. P., Sun, J., Brown, T. T., Julian, C. G., & Erlandson, K. M. (2023) · Aging Cell · doi:10.1111/acel.14025 · Cited by 11 · see citing works
“…is therefore also possible that while aging with chronic HIV infec - tion (a long-term stressor), alternative mechanistic pathways in cells and tissues are activated and integrated in response to exercise training (repetitive acute stressor), suggesting biological resilience (Hadley et al., 2017 ).”
BackgroundKim, J., Park, S., & Lee, C. D. (2023) · Journal of Applied Gerontology · doi:10.1177/07334648231183772 · Cited by 11 · see citing works
“Re-silience refers to the ability to bounce back after a distressed event or adversity in life (Hadley et al., 2017).”
BackgroundDevelopment of the Clinical pHysical rEsilience assEssment Scale (CHEES) in Chinese Older Adults
Li, J., Liu, P., Zhang, Y., Wang, G., Zhou, Y., Xing, Y., Zhang, L., Li, Y., & Ma, L. (2024) · The Journal of Frailty & Aging · doi:10.14283/jfa.2024.24 · Cited by 10 · see citing works
“In contrast, those with lower physical resilience are more likely to experience poor physical functions and may even face death when exposed to stressors (4).”
Next steps: Operationalizing resilience research
Brown, L. L., Cohen, B., Costello, R. B., et al. (2023) · Stress and Health · doi:10.1002/smi.3256 · Cited by 10 · see citing works
Zhang, H., Hao, M., Li, Y., Hu, Z., Liu, Z., Jiang, S., Li, J., & Wang, X. (2023) · Innovation in Aging · doi:10.1093/geroni/igad118 · Cited by 9 · see citing works
“Hence, it is of great importance to assess PR in older adults to contribute to decision making in healthcare, such as therapeutic decision making, acute care management, rehabilitation therapy, and assessment of adverse medication effects (3).”
BackgroundO’Connor, J. D., O’Connell, M. D. L., Romero‐Ortuño, R., Hernández, B., Newman, L., Reilly, R. B., Kenny, R. A., & Knight, S. P. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00261 · Cited by 9 · see citing works
Cohen, A. B., McAvay, G., Geda, M. E., Chattopadhyay, S., Lee, S., Acampora, D., Araujo, K. L. B., Charpentier, P. A., Gill, T. M., Hajduk, A. M., et al. (2022) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18146 · Cited by 9 · see citing works
Carneiro, M. A. S., Júnior, G. N. D. O., Castro-e-Souza, P., de Oliveira, A. A., Nunes, P. R. P., Izquierdo, M., Cadore, E. L., & Cyrino, E. S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101673 · Cited by 8 · see citing works
Loss of resilience contributes to detrusor underactivity in advanced age
Ramasamy, R., Baker, D. S., Lemtiri‐Chlieh, F., Rosenberg, D. A., Woon, E., Al‐Naggar, I. M., Hardy, C. C., Levine, E. S., Kuchel, G. A., Bartley, J. M., et al. (2023) · Biogerontology · doi:10.1007/s10522-022-10005-y · Cited by 8 · see citing works
“By re-casting DU as a failure of resilient aging rather than as a detrusor disease, this mouse model offers a valuable research methodology for clinical detrusor/voiding disorders (Kirkland et al. 2016; Hadley et al. 2017).”
MethodSelf-citationMADRID+90 study on factors associated with longevity: Study design and preliminary data
Fernández‐Blázquez, M. A., del Ser, T., Payo, B. F., Ávila‐Villanueva, M., Valentí, M., Benítez-Robredo, M. T., Acuña, A. B., Pérez, E. J. P., Quilis-Sancho, J., Pastor, A. B., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251796 · Cited by 8 · see citing works
“For example, evidence suggests that longevity is associated with a heterogeneous set of factors such as genetic background [4], physical exercise, especially when the Body Mass Index is between 20 and 25 kg/ m2 [5], effectiveness in managing daily stress [6], social support [7], having a purpose in life [8], first-deg…”
BackgroundLin, C., Ou, C.-H., Chang, C., & Hu, F. (2023) · The Journal of Frailty & Aging · doi:10.14283/jfa.2023.8 · Cited by 7 · see citing works
“Indeed, successful aging often depends on a person’s response to the inevitability of latelife stressors (1).”
BackgroundResilience, Survival, and Functional Independence in Older Adults Facing Critical Illness
Cobert, J. M., Jeon, S. Y., Boscardin, J., Chapman, A. C., Espejo, E., Maley, J. H., Lee, S. J., & Smith, A. K. (2024) · CHEST Journal · doi:10.1016/j.chest.2024.04.039 · Cited by 7 · see citing works
Ravi, D. K., Heimhofer, C., Taylor, W. R., & Singh, N. B. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.678965 · Cited by 7 · see citing works
Epigenetic Aging Helps Explain Differential Resilience in Older Adults
Klopack, E. T., & Crimmins, E. M. (2024) · Demography · doi:10.1215/00703370-11466635 · Cited by 8 · see citing works
Cost trajectories as a measure of functional resilience after hospitalization in older adults
Colon-Emeric, C. S., Huang, J., Pieper, C. F., et al. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01481-8 · Cited by 7 · see citing works
Self-citationLee, G. C., Moreira, A. G., Hinojosa, C. A., Benavides, R., Winter, C., Anderson, A. C., Chen, C.-J., Borsa, N., Hastings, G., Black, C. A., et al. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.736835 · Cited by 7 · see citing works
- Authors
- Hadley, E. C., Kuchel, G. A., Newman, A. B., Allore, H. G., Bartley, J. M., Bergeman, C. S., Blinov, M. L., Colon-Emeric, C. S., Dabhar, F. S., Dugan, L. L., Dutta, C., Eldadah, B. A., Ferrucci, L., Kirkland, J. L., Kritchevsky, S. B., Lipsitz, L. A., Nadkarni, N. K., Reed, M. J., Schmader, K. E., Sierra, F., Studenski, S. A., Varadhan, R., Walston, J. D., Whitson, H. E., & Yung, R.
- Affiliations
- National Institutes of Health (US)
- UConn Health (US)
- University of Pittsburgh (US)
- Yale University (US)
- University of Notre Dame (US)
- University of Connecticut (US)
- Duke University (US)
- Stanford Medicine (US)
- Vanderbilt University (US)
- Mayo Clinic (US)
- Wake Forest University Health Sciences (US)
- Beth Israel Deaconess Medical Center (US)
- University of Washington (US)
- Johns Hopkins University (US)
- University of Michigan (US)
- Corresponding author
- Newman, Anne B
- ORCID
- Kuchel, George A
- Newman, Anne B
- Allore, Heather G
- Bartley, Jenna M
- Bergeman, Cindy S
- Blinov, Michael L
- Colon-Emeric, Cathleen S
- Dugan, Laura L
- Ferrucci, Luigi
- Kirkland, James L
- Kritchevsky, Stephen B
- Lipsitz, Lewis A
- Nadkarni, Neelesh K
- Reed, May J
- Schmader, Kenneth E
- Sierra, Felipe
- Studenski, Stephanie A
- Varadhan, Ravi
- Walston, Jeremy D
- Whitson, Heather E
- Yung, Raymond
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-05-05
- Volume
- 72
- Issue
- 7
- Pages
- 980-990
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC5861884
- OpenAlex
- W2611341457
- Semantic Scholar
- 8a4b73ffa8c7090642e3d117a7432fc9e395e304
- Cited by
- 173
- References
- 32
- Citations by year
- 2026: 22 · 2025: 20 · 2024: 16 · 2023: 22 · 2022: 29 · 2021: 17 · 2020: 13 · 2019: 20 · 2018: 11 · 2017: 3
- FWCI
- 15.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- The Journals of Gerontology Series A (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- University of Michigan Library
- Funders
- National Institute on Aging
- Topics
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- resilience, human aging, stress response, homeostatic responses, older adults, biological aging, sensor technology
- MeSH terms
- Adaptation, Psychological, Aged, Aging, Consensus Statements as Topic, Female, Humans, Male, Stress, Psychological, Geriatric Assessment, Behavioral Research, Resilience, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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