The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging
Open accessAbstract
BACKGROUND/OBJECTIVES: Resilience, the ability to resist or recover from adverse effects of a stressor, is of widespread interest in social, psychologic, biologic, and medical research and particularly salient as the capacity to respond to stressors becomes diminished with aging. To date, research on human resilience responses to and factors influencing these responses has been limited. METHODS: The National Institute on Aging convened a workshop in August 2015 on needs for research to improve measures to predict and assess resilience in human aging. Effects of aging-related factors in impairing homeostatic responses were developed from examples illustrating multiple determinants of clinical resilience outcomes. Research directions were identified by workshop participants. RESULTS: Research needs identified included expanded uses of clinical data and specimens in predicting or assessing resilience, and contributions from epidemiological studies in identifying long-term predictors. Better measures, including simulation tests, are needed to assess resilience and its determinants. Mechanistic studies should include exploration of influences of biologic aging processes on human resiliencies. Important resource and infrastructure needs include consensus phenotype definitions of specific resiliencies, capacity to link epidemiological and clinical resilience data, sensor technology to capture responses to stressors, better laboratory animal models of human resiliencies, and new analytic methods to understand the effects of multiple determinants of stress responses. CONCLUSIONS: Extending the focus of care and research to improving the capacity to respond to stressors could benefit older adults in promoting a healthier life span.
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“Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [17]
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“The Geroscience Hypothesis holds that these pillars of aging, including cellular senescence, tend to progress in concert and may be root-cause contributors to the pathophysiology of multiple diseases”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [17]
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Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · cited 2×
“In addition to these illustrative examples, it is likely that many other basic mechanisms implicated in the biology of aging (18,19), may individually or collectively influence physiologic resilience.”
BackgroundThe Construct of Resilience: A Critical Evaluation and Guidelines for Future Work
Luthar, S. S., Cicchetti, D., & Becker, B. (2000) · Child Development · doi:10.1111/1467-8624.00164 · Cited by 9,381
Geroscience: Linking Aging to Chronic Disease
Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764
Self-citationFrailty as a predictor of surgical outcomes in older patients
Makary, M. A., Segev, D. L., Pronovost, P. J., Syin, D., Bandeen-Roche, K., Patel, P., Takenaga, R., Devgan, L., Holzmueller, C. G., Tian, J., et al. (2010) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2010.01.028 · Cited by 2,184 · cited 1×
“Studies on frailty in older persons, which has been associated with impairments in some types of resilience (eg, postsurgical outcomes) (15) suggest that at a minimum five major, interconnected physiologic domains may influence degree of resilience: autonomic nervous system, hypo-thalamic-pituitary…”
BackgroundGeriatric Syndromes: Clinical, Research, and Policy Implications of a Core Geriatric Concept
Inouye, S. K., Studenski, S. A., Tinetti, M. E., & Kuchel, G. A. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01156.x · Cited by 1,887 · cited 1×
“The possibility of shared physiologic mechanisms responsible for decrements in multiple types of resilience is of particular interest (13).”
BackgroundSelf-citationAllostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging
Seeman, T. E., McEwen, B. S., Rowe, J. W., & Singer, B. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081072698 · Cited by 1,385 · cited 1×
“Conversely, the concept of allostatic load (9), suggests that repeated or chronic stress may result in “wear and tear” on neural and endocrine systems over time, with potentially negative effects on resilience.”
BackgroundNewman, A. B., Simonsick, E. M., Naydeck, B. L., Boudreau, R. M., Kritchevsky, S. B., Nevitt, M. C., Pahor, M., Satterfield, S., Brach, J. S., Studenski, S. A., et al. (2006) · JAMA · doi:10.1001/jama.295.17.2018 · Cited by 934 · cited 1×
“…role of resilience as long-term predictors comes from studies on the relationship of alterations in stability of blood pressure and gait to risk of future adverse clinical and functional outcomes, and studies on heart-rate recovery following a 400 m walk as a predictor of long-term mortality (22).”
BackgroundSelf-citationDynamics of stability: the physiologic basis of functional health and frailty
Lipsitz, L. A. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.3.b115 · Cited by 646 · cited 1×
“Time series analyses can distinguish patterns that reflect the integration and correlation of multiple inputs over different scales in time or space (eg, fractal patterns) from those that are random, lacking any functional connection among them (eg, white noise) (17).”
BackgroundSelf-citationHazzard’s Geriatric Medicine and Gerontology
Dwolatzky, T. (2009) · JAMA · doi:10.1001/jama.2009.1561 · Cited by 524
Biological mechanisms underlying the role of physical fitness in health and resilience
Silverman, M. N., & Deuster, P. A. (2014) · Interface Focus · doi:10.1098/rsfs.2014.0040 · Cited by 416 · cited 1×
“Population heterogeneity in such studies provides opportunities to increase the specificity of understanding of resilience factors, for example, to identify which components of physical activity may confer greater resilience to a given stressor (21).”
Background
Research works printed but not linked: 1
- Kuchel, 2017, Aging and homeostatic regulation, 1871
Cited by
Sorted by citations
Cellular senescence and senolytics: the path to the clinic
Chaib, S., Tchkonia, T., & Kirkland, J. L. (2022) · Nature Medicine · doi:10.1038/s41591-022-01923-y · Cited by 1,134
Self-citationA complex systems approach to aging biology
Cohen, A. A., Ferrucci, L., Fülöp, T., Gravel, D., Hao, N., Kriete, A., Levine, M. E., Lipsitz, L. A., Olde Rikkert, M. G. M., Rutenberg, A., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00252-6 · Cited by 221
Self-citationMurine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging
Kimmel, J. C., Penland, L., Rubinstein, N. D., Hendrickson, D. G., Kelley, D. R., & Rosenthal, A. Z. (2019) · Genome Research · doi:10.1101/gr.253880.119 · Cited by 184
“Single-cell measurements collected during functional challenges may also reveal the dynamics of perturbation and subsequent return to homeostasis necessary to evaluate “resilience” in a given cell type (Kirkland et al. 2016; Hadley et al. 2017).”
BackgroundDiscovery, development, and future application of senolytics: theories and predictions
Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T., & Kirkland, J. L. (2020) · The FEBS Journal · doi:10.1111/febs.15264 · Cited by 160
Self-citationIntrinsic Capacity in Older Adults: Recent Advances
Zhou, Y., & Ma, L. (2022) · Aging and Disease · doi:10.14336/ad.2021.0818 · Cited by 148
“Physical resilience is a new concept in the field of geriatrics introduced by the National Institute on Aging (NIA)[18]; it is defined as the ability to recover from physically or psychologically traumatic events [19].”
Background
Metadata
- Authors
- Hadley, E. C., Kuchel, G. A., Newman, A. B., Allore, H. G., Bartley, J. M., Bergeman, C. S., Blinov, M. L., Colon-Emeric, C. S., Dabhar, F. S., Dugan, L. L., Dutta, C., Eldadah, B. A., Ferrucci, L., Kirkland, J. L., Kritchevsky, S. B., Lipsitz, L. A., Nadkarni, N. K., Reed, M. J., Schmader, K. E., Sierra, F., Studenski, S. A., Varadhan, R., Walston, J. D., Whitson, H. E., & Yung, R.
- Affiliations
- National Institutes of Health (US)
- UConn Health (US)
- University of Pittsburgh (US)
- Yale University (US)
- University of Notre Dame (US)
- University of Connecticut (US)
- Duke University (US)
- Stanford Medicine (US)
- Vanderbilt University (US)
- Mayo Clinic (US)
- Wake Forest University Health Sciences (US)
- Beth Israel Deaconess Medical Center (US)
- University of Washington (US)
- Johns Hopkins University (US)
- University of Michigan (US)
- Corresponding author
- Newman, Anne B
- ORCID
- Kuchel, George A
- Newman, Anne B
- Allore, Heather G
- Bartley, Jenna M
- Bergeman, Cindy S
- Blinov, Michael L
- Colon-Emeric, Cathleen S
- Dugan, Laura L
- Ferrucci, Luigi
- Kirkland, James L
- Kritchevsky, Stephen B
- Lipsitz, Lewis A
- Nadkarni, Neelesh K
- Reed, May J
- Schmader, Kenneth E
- Sierra, Felipe
- Studenski, Stephanie A
- Varadhan, Ravi
- Walston, Jeremy D
- Whitson, Heather E
- Yung, Raymond
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-05-05
- Volume
- 72
- Issue
- 7
- Pages
- 980-990
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC5861884
- OpenAlex
- W2611341457
- Semantic Scholar
- 8a4b73ffa8c7090642e3d117a7432fc9e395e304
- Cited by
- 173
- References
- 32
- Citations by year
- 2026: 22 · 2025: 20 · 2024: 16 · 2023: 22 · 2022: 29 · 2021: 17 · 2020: 13 · 2019: 20 · 2018: 11 · 2017: 3
- FWCI
- 15.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- The Journals of Gerontology Series A (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- University of Michigan Library
- Funders
- National Institute on Aging
- Topics
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- resilience, human aging, stress response, homeostatic responses, older adults, biological aging, sensor technology
- MeSH terms
- Adaptation, Psychological, Aged, Aging, Consensus Statements as Topic, Female, Humans, Male, Stress, Psychological, Geriatric Assessment, Behavioral Research, Resilience, Psychological
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