The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.
High Intensity Interval Training Improves Physical Performance and Frailty in Aged Mice
Abstract
Sarcopenia and frailty are highly prevalent in older individuals, increasing the risk of disability and loss of independence. High intensity interval training (HIIT) may provide a robust intervention for both sarcopenia and frailty by achieving both strength and endurance benefits with lower time commitments than other exercise regimens. To better understand the impacts of HIIT during aging, we compared 24-month-old C57BL/6J sedentary mice with those that were administered 10-minute uphill treadmill HIIT sessions three times per week over 16 weeks. Baseline and end point assessments included body composition, physical performance, and frailty based on criteria from the Fried physical frailty scale. HIIT-trained mice demonstrated dramatic improvement in grip strength (HIIT 10.9% vs -3.9% in sedentary mice), treadmill endurance (32.6% vs -2.0%), and gait speed (107.0% vs 39.0%). Muscles from HIIT mice also exhibited greater mass, larger fiber size, and an increase in mitochondrial biomass. Furthermore, HIIT exercise led to a dramatic reduction in frailty scores in five of six mice that were frail or prefrail at baseline, with four ultimately becoming nonfrail. The uphill treadmill HIIT exercise sessions were well tolerated by aged mice and led to performance gains, improvement in underlying muscle physiology, and reduction in frailty.
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“those undergoing 10-min uphill treadmill, high-intensity interval training (HIIT) sessions over 16 weeks showed significant improvements in grip strength, treadmill endurance, and gait speed, and exhibited increased muscle mass, larger muscle fiber size, and greater mitochondrial biomass [19].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [19]
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Cites
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Exercise training and nutritional supplementation for physical frailty in very elderly people
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High-Intensity Strength Training in Nonagenarians: Effects on Skeletal Muscle
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“These findings are consistent with the evidence that HIIT is safe for both healthy and frail older adults (8,9,27) and also supports individually tailoring exercise programs (58).”
BackgroundResultPahor, M., Guralnik, J. M., Ambrosius, W. T., Blair, S., Bonds, D. E., Church, T. S., Espeland, M. A., Fielding, R. A., Gill, T. M., Groessl, E. J., et al. (2014) · JAMA · doi:10.1001/jama.2014.5616 · Cited by 1,427
Transitions between frailty states among community-living older persons
Gill, T. M., Gahbauer, E. A., Allore, H. G., & Han, L. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.4.418 · Cited by 1,141 · cited 1×
“Interestingly there existed a natural fluctuation between robust and prefrail states in a community-dwelling elderly adults (35).”
BackgroundMouse Models in Aging Research
FLURKEY, K., MCURRER, J., & HARRISON, D. (2007) · The Mouse in Biomedical Research · doi:10.1016/b978-012369454-6/50074-1 · Cited by 723
High-Intensity Intermittent Exercise and Fat Loss
Boutcher, S. H. (2010) · Journal of Obesity · doi:10.1155/2011/868305 · Cited by 614
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A Clinical Frailty Index in Aging Mice: Comparisons With Frailty Index Data in Humans
Whitehead, J. C., Hildebrand, B. A., Sun, M., Rockwood, M. R. H., Rose, R. A., Rockwood, K. J., & Howlett, S. E. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt136 · Cited by 514
Giné-Garriga, M., Roqué-Fíguls, M., Coll-Planas, L., Sitjà-Rabert, M., & Salvà, A. (2014) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2013.11.007 · Cited by 468
Cited by
Sorted by citations
Sarcopenia: A Contemporary Health Problem among Older Adult Populations
Papadopoulou, S. Κ. (2020) · Nutrients · doi:10.3390/nu12051293 · Cited by 672
The degree of frailty as a translational measure of health in aging
Howlett, S. E., Rutenberg, A. D., & Rockwood, K. J. (2021) · Nature Aging · doi:10.1038/s43587-021-00099-3 · Cited by 357
Mouse models of sarcopenia: classification and evaluation
Xie, W., He, M., Yu, D., Wu, Y., Wang, X., Lv, S., Xiao, W., & Li, Y. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12709 · Cited by 240
“Of course, there are also natural ageing mouse models of other ages, such as 27 months old,(42) 88–96 weeks old,(43) 22 months old,(44,45) and 24 months old.(46) For sex selection,”
BackgroundThe impact of physical activity and sedentary behaviors on frailty levels
Kehler, D. S., & Theou, O. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.03.004 · Cited by 166
You, Y., Li, W., Liu, J., Li, X., Fu, Y., & Ma, X. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.697633 · Cited by 134
Metadata
- Authors
- Seldeen, K. L., Lasky, G., Leiker, M. M., Pang, M., Personius, K. E., & Troen, B. R.
- Affiliations
- VA Western New York Healthcare System (US)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Troen, Bruce Robert
- Venue
- The Journals of Gerontology Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-06-17
- Volume
- 73
- Issue
- 4
- Pages
- 429-437
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2626525317
- Cited by
- 104
- References
- 60
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 14 · 2020: 16 · 2019: 13 · 2018: 6 · 2017: 1
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- Rehabilitation Research and Development (RX001066)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- high-intensity interval training, frailty, sarcopenia, aging, physical performance, grip strength, treadmill endurance, walking speed, muscle fiber size, muscle mass, exercise intervention, aged mice
- MeSH terms
- High-Intensity Interval Training, Frailty, Physical Functional Performance, Animals, Body Composition, Exercise Test, Male, Mice, Inbred C57BL, Mitochondria, Muscle, Random Allocation, Absorptiometry, Photon, Muscle, Skeletal, Mice
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