Cited by 104Frailty in Older AdultsNutrition and Health in AgingCardiovascular and exercise physiology

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High Intensity Interval Training Improves Physical Performance and Frailty in Aged Mice

Seldeen, Kenneth Ladd, Lasky, Ginger, Leiker, Merced Marie, Pang, Manhui, Personius, Kirkwood Ely, Troen, Bruce Robert·2018·The Journals of Gerontology Series A

DOI 10.1093/gerona/glx120

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Abstract

Sarcopenia and frailty are highly prevalent in older individuals, increasing the risk of disability and loss of independence. High intensity interval training (HIIT) may provide a robust intervention for both sarcopenia and frailty by achieving both strength and endurance benefits with lower time commitments than other exercise regimens. To better understand the impacts of HIIT during aging, we compared 24-month-old C57BL/6J sedentary mice with those that were administered 10-minute uphill treadmill HIIT sessions three times per week over 16 weeks. Baseline and end point assessments included body composition, physical performance, and frailty based on criteria from the Fried physical frailty scale. HIIT-trained mice demonstrated dramatic improvement in grip strength (HIIT 10.9% vs -3.9% in sedentary mice), treadmill endurance (32.6% vs -2.0%), and gait speed (107.0% vs 39.0%). Muscles from HIIT mice also exhibited greater mass, larger fiber size, and an increase in mitochondrial biomass. Furthermore, HIIT exercise led to a dramatic reduction in frailty scores in five of six mice that were frail or prefrail at baseline, with four ultimately becoming nonfrail. The uphill treadmill HIIT exercise sessions were well tolerated by aged mice and led to performance gains, improvement in underlying muscle physiology, and reduction in frailty.

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See all 104

Authors: Seldeen, K. L., Lasky, G., Leiker, M. M., Pang, M., Personius, K. E., & Troen, B. R.
Affiliations: VA Western New York Healthcare System (US)
University at Buffalo, State University of New York (US)
Corresponding author: Troen, Bruce Robert
ORCID: Seldeen, Kenneth Ladd
Personius, Kirkwood Ely
Troen, Bruce Robert
Venue: The Journals of Gerontology Series A
Publisher: Oxford University Press (OUP)
Published: 2017-06-17
Volume: 73
Issue: 4
Pages: 429-437
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/glx120
OpenAlex: W2626525317
Cited by: 104
References: 60
Citations by year: 2026: 8 · 2025: 14 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 14 · 2020: 16 · 2019: 13 · 2018: 6 · 2017: 1
FWCI: 5.98
Type: journal article
Language: en
Open access: closed
Locations: The Journals of Gerontology Series A (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: Rehabilitation Research and Development (RX001066)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: high-intensity interval training, frailty, sarcopenia, aging, physical performance, grip strength, treadmill endurance, walking speed, muscle fiber size, muscle mass, exercise intervention, aged mice
MeSH terms: High-Intensity Interval Training, Frailty, Physical Functional Performance, Animals, Body Composition, Exercise Test, Male, Mice, Inbred C57BL, Mitochondria, Muscle, Random Allocation, Absorptiometry, Photon, Muscle, Skeletal, Mice

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High Intensity Interval Training Improves Physical Performance and Frailty in Aged Mice

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